公开(公告)号：US20240358674A1

公开(公告)日：2024-10-31

申请号：US18655687

申请日：2024-05-06

Applicant: RHODES TECHNOLOGIES

Inventor： Ping CHANG ,  Marc BROWN ,  Charles EVANS

IPC: A61K31/352 ,  A61K9/00 ,  A61K31/05 ,  A61K47/06 ,  A61K47/10 ,  A61K47/44

CPC classification number: A61K31/352 ,  A61K9/006 ,  A61K31/05 ,  A61K47/06 ,  A61K47/10 ,  A61K47/44

Abstract: The present disclosure provides pharmaceutical compositions comprising a cannabinoid, and dosage forms comprising same, for oral delivery, such as sublingual or buccal delivery. The compositions of the present disclosure are substantially homogeneous and remain stable and monophasic upon storage. Also provided are methods of using the compositions for pain management and to treat various diseases and conditions, including dementia, sleep disorders, movement disorders, mental disorders, and multiple sclerosis.

公开(公告)号：US11773107B2

公开(公告)日：2023-10-03

申请号：US16817794

申请日：2020-03-13

Applicant: Rhodes Technologies

Inventor： Robert J. Kupper ,  Raymond C. Glowaky

IPC: C07D489/08 ,  C07D491/20 ,  C07D489/09 ,  A61K9/00 ,  A61K31/485 ,  A61K45/06 ,  C07D489/02

CPC classification number: C07D489/08 ,  A61K9/0053 ,  A61K31/485 ,  A61K45/06 ,  C07D489/02 ,  C07D489/09 ,  C07D491/20

Abstract: This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III):




or a pharmaceutically acceptable salts thereof, wherein R1 is H or CH3, R2 is H or OH, n is 0, 1, 2 or 3, R3 and R4 are independently H or optionally substituted C1-C4 alkyl, or when n is 0, then R3 and R4 and the carbon atoms to which they are attached together form six, or seven membered ring, which is optionally mono or disubstituted by C1-C4 alkyl. The invention also relates to oxycodone ketal compounds of Formula (IV) or (V):





or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain.

公开(公告)号：US11731979B2

公开(公告)日：2023-08-22

申请号：US17407222

申请日：2021-08-20

Applicant: Rhodes Technologies

Inventor： Robert J. Kupper ,  Raymond C. Glowaky

IPC: C07D489/08 ,  C07D491/20 ,  C07D489/09 ,  A61K9/00 ,  A61K31/485 ,  A61K45/06 ,  C07D489/02

CPC classification number: C07D489/08 ,  A61K9/0053 ,  A61K31/485 ,  A61K45/06 ,  C07D489/02 ,  C07D489/09 ,  C07D491/20

Abstract: This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III): or a pharmaceutically acceptable salts thereof, wherein R1 is H or CH3, R2 is H or OH, n is 0, 1, 2 or 3, R3 and R4 are independently H or optionally substituted C1-C4 alkyl, or when n is 0, then R3 and R4 and the carbon atoms to which they are attached together form six, or seven membered ring, which is optionally mono or disubstituted by C1-C4 alkyl. The invention also relates to oxycodone ketal compounds of Formula (IV) or (V): or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain.

公开(公告)号：US11384091B2

公开(公告)日：2022-07-12

申请号：US16900600

申请日：2020-06-12

Applicant: Purdue Pharma L.P. ,  Purdue Pharmaceuticals L.P. ,  Rhodes Technologies

Inventor： Robert Chapman ,  Lonn S. Rider ,  Qi Hong ,  Donald Kyle ,  Robert Kupper

IPC: A61K31/485 ,  C07D489/08 ,  C07D489/02 ,  A61K9/20 ,  A61K9/48 ,  A61K9/14 ,  C07D489/04

Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.

公开(公告)号：US11236098B2

公开(公告)日：2022-02-01

申请号：US17202320

申请日：2021-03-15

Applicant: Purdue Pharma L.P. ,  Purdue Pharmaceuticals L.P. ,  Rhodes Technologies

Inventor： Robert Chapman ,  Lonn S. Rider ,  Qi Hong ,  Robert Kupper ,  Donald J. Kyle

IPC: A61K31/485 ,  C07D489/08 ,  C07D489/02 ,  A61K9/20 ,  A61K9/48 ,  A61K9/14 ,  C07D489/04

Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.

公开(公告)号：US20210299046A1

公开(公告)日：2021-09-30

申请号：US16642168

申请日：2018-08-10

Applicant: Rhodes Technologies

Inventor： Ping CHANG ,  Zhenze HU ,  Yuanyuan TAO

IPC: A61K9/107 ,  A61K31/352 ,  A61K9/00 ,  A61K47/44 ,  A61K47/10 ,  A61K47/02 ,  A61K9/06

Abstract: The invention provides emulsion compositions comprising at least one cannabinoid compound, and methods for making the same. The emulsion compositions are stable, well tolerated and are capable of delivering therapeutically effective amounts of cannabiniods to target sites, including sites on the surface of and/or within an eye. Also provided are methods of using the compositions to provide ocular neuroprotection and/or to treat ophthalmic conditions such as glaucoma.

公开(公告)号：US11091496B2

公开(公告)日：2021-08-17

申请号：US16517974

申请日：2019-07-22

Applicant: RHODES TECHNOLOGIES

Inventor： Robert J. Kupper ,  Raymond C. Glowaky

IPC: C07D489/08 ,  C07D491/20 ,  C07D489/09 ,  A61K9/00 ,  A61K31/485 ,  A61K45/06 ,  C07D489/02

Abstract: This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III): or a pharmaceutically acceptable salts thereof, wherein R1 is H or CH3, R2 is H or OH, n is 0, 1, 2 or 3, R3 and R4 are independently or optionally substituted C1-C4 alkyl, or when n is 0, then R3 and R4 and the carbon atoms to which they are attached together form six, or seven membered ring, which is optionally mono or disubstituted by C1-C4 alkyl. The invention also relates to oxycodone ketal compounds of Formula (IV) or (V): or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain.

公开(公告)号：US20210198268A1

公开(公告)日：2021-07-01

申请号：US17202320

申请日：2021-03-15

Applicant: Purdue Pharma L.P. ,  Purdue Pharmaceuticals L.P. ,  Rhodes Technologies

Inventor： Robert CHAPMAN ,  Lonn S. RIDER ,  Qi HONG ,  Robert KUPPER ,  Donald J. KYLE

IPC: C07D489/08 ,  A61K9/20 ,  A61K9/14 ,  A61K9/48 ,  A61K31/485 ,  C07D489/04 ,  C07D489/02

Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.

公开(公告)号：US20200317684A1

公开(公告)日：2020-10-08

申请号：US16817794

申请日：2020-03-13

Applicant: Rhodes Technologies

Inventor： Robert J. KUPPER ,  Raymond C. GLOWAKY

IPC: C07D489/08 ,  C07D491/20 ,  C07D489/09 ,  A61K9/00 ,  A61K31/485 ,  A61K45/06 ,  C07D489/02

Abstract: This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III): or a pharmaceutically acceptable salts thereof, wherein R1 is H or CH3, R2 is H or OH, n is 0, 1, 2 or 3, R3 and R4 are independently H or optionally substituted C1-C4 alkyl, or when n is 0, then R3 and R4 and the carbon atoms to which they are attached together form six, or seven membered ring, which is optionally mono or disubstituted by C1-C4 alkyl. The invention also relates to oxycodone ketal compounds of Formula (IV) or (V): or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain.

公开(公告)号：US20190314364A1

公开(公告)日：2019-10-17

申请号：US16446397

申请日：2019-06-19

Applicant: Rhodes Technologies

Inventor： C. Frederick M. HUNTLEY ,  Erik Wayne KATAISTO ,  Helge Alfred REISCH ,  Archana SHARMA

IPC: A61K31/485 ,  A61P25/04 ,  C07D489/12

Abstract: The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.