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公开(公告)号：US20060263896A1
公开(公告)日：2006-11-23
申请号：US11435720
申请日：2006-05-18
Applicant: Bryan Hollebone , John Dawson , Rajesh Krishnamurthy , Michael Donkers
Inventor： Bryan Hollebone , John Dawson , Rajesh Krishnamurthy , Michael Donkers
IPC: G01N21/00
CPC classification number: G01N21/0303 , G01N21/05 , G01N21/171 , G01N21/645 , G01N21/65 , G01N21/94 , G01N33/1813 , G01N33/1826 , G01N2021/0378 , G01N2021/6469 , G01N2201/0221 , G01N2201/0634 , Y10T436/12 , Y10T436/25375
Abstract: A fluid contamination analyzer has a sample cell containing a trapping medium capable of trapping contaminants suspended in the aqueous fluid flowing through the trapping medium, a light source for illuminating the trapping medium to cause the entrapped contaminants generate a secondary radiation indicative of the identity and quantity of the contaminants, and a photodetector for receiving the secondary radiation. The fluid contamination analyzer has a reflective shell in the form of an ellipsoid extending at least partially around the sample cell and the detector, the sample cell being positioned at one of the focal points of the ellipsoid, and the photodetector at the other point of the ellipsoid to receive the secondary radiation reflected by the reflective shell.
Abstract translation: 流体污染分析器具有含有捕获介质的捕集介质的捕获介质，该捕获介质能够捕获悬浮在流过捕获介质的水性流体中的污染物，用于照射捕获介质的光源以引起捕获的污染物产生指示身份和数量的次级辐射 的污染物，以及用于接收二次辐射的光电检测器。 流体污染分析器具有至少部分地围绕样品池和检测器延伸的椭圆形形式的反射壳体，样品池位于椭圆体的焦点之一处，并且光电检测器在另一点处 椭圆体以接收由反射壳体反射的二次辐射。
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Patent Agency Ranking
公开(公告)号：US11859233B2
公开(公告)日：2024-01-02
申请号：US17681899
申请日：2022-02-28
Applicant: Rajesh Krishnamurthy
Inventor： Rajesh Krishnamurthy
CPC classification number: C12Q1/24 , C12Q1/04 , B01L3/50825 , B01L3/502753 , B01L2200/0647 , B01L2200/0684 , B01L2200/10 , B01L2200/141 , B01L2300/023 , B01L2300/044 , B01L2300/0681
Abstract: Devices and methods are provided to detect the presence of bacteria and small microorganisms, and to identify various microbial attributes rapidly.
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公开(公告)号：US20220290207A1
公开(公告)日：2022-09-15
申请号：US17681899
申请日：2022-02-28
Applicant: Rajesh Krishnamurthy
Inventor： Rajesh Krishnamurthy
Abstract: Devices and methods are provided to detect the presence of bacteria and small microorganisms, and to identify various microbial attributes rapidly.
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公开(公告)号：US20160115520A1
公开(公告)日：2016-04-28
申请号：US14893689
申请日：2014-05-30
Applicant: Rajesh KRISHNAMURTHY
Inventor： Rajesh KRISHNAMURTHY
CPC classification number: C12Q1/24 , B01L3/502753 , B01L3/50825 , B01L2200/0647 , B01L2200/0684 , B01L2200/10 , B01L2200/141 , B01L2300/023 , B01L2300/044 , B01L2300/0681 , C12Q1/04
Abstract: Devices and methods are provided to detect the presence of bacteria and small microorganisms, and to identify various microbial attributes rapidly.
Abstract translation: 提供设备和方法来检测细菌和小微生物的存在，并快速鉴定各种微生物属性。
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公开(公告)号：US07727772B2
公开(公告)日：2010-06-01
申请号：US11435720
申请日：2006-05-18
Applicant: Bryan R. Hollebone , John Wendell Dawson , Rajesh Krishnamurthy , Michael Allan Donkers
CPC classification number: G01N21/0303 , G01N21/05 , G01N21/171 , G01N21/645 , G01N21/65 , G01N21/94 , G01N33/1813 , G01N33/1826 , G01N2021/0378 , G01N2021/6469 , G01N2201/0221 , G01N2201/0634 , Y10T436/12 , Y10T436/25375
Abstract: A fluid contamination analyzer has a sample cell containing a trapping medium capable of trapping contaminants suspended in the aqueous fluid flowing through the trapping medium, a light source for illuminating the trapping medium to cause the entrapped contaminants generate a secondary radiation indicative of the identity and quantity of the contaminants, and a photodetector for receiving the secondary radiation. The fluid contamination analyzer has a reflective shell in the form of an ellipsoid extending at least partially around the sample cell and the detector, the sample cell being positioned at one of the focal points of the ellipsoid, and the photodetector at the other point of the ellipsoid to receive the secondary radiation reflected by the reflective shell.
Abstract translation: 流体污染分析器具有含有捕获介质的捕集介质的捕获介质，该捕获介质能够捕获悬浮在流过捕获介质的水性流体中的污染物，用于照射捕获介质的光源以引起捕获的污染物产生指示身份和数量的次级辐射 的污染物，以及用于接收二次辐射的光电检测器。 流体污染分析器具有至少部分地围绕样品池和检测器延伸的椭圆形形式的反射壳体，样品池位于椭圆体的焦点之一处，并且光电检测器在另一点处 椭圆体以接收由反射壳体反射的二次辐射。
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公开(公告)号：US20070196364A1
公开(公告)日：2007-08-23
申请号：US11626264
申请日：2007-01-23
Applicant: Rajesh Krishnamurthy , Raj Suryanarayanan , Xiangmin Liao
Inventor： Rajesh Krishnamurthy , Raj Suryanarayanan , Xiangmin Liao
IPC: A61K39/395 , A61K38/17 , A61K31/7012
CPC classification number: A61K38/17 , A61K31/7012 , C07K16/00
Abstract: A process for lyophilization or freeze-drying of a pharmaceutical product is provided and a liquid formulation suitable for lyophilization. In particular, a process for lyophilization or freeze-drying a liquid formulation that includes a protein active agent, a bulking agent and a saccharide stabilizing agent is provided. The saccharide to bulking agent ratio and the protein concentration of the formulation are important factors that affect crystallization of the bulking agent during lyophilization and storage as are some processing conditions. In one embodiment, the saccharide is a disaccharide, such as sucrose and the crystalline bulking agent is mannitol. The protein can be an antibody or a non-antibody protein.
Abstract translation: 提供了用于冻干或冷冻干燥药物的方法，以及适用于冻干的液体制剂。 特别地，提供了包含蛋白质活性剂，增量剂和糖类稳定剂的液体制剂的冻干或冷冻干燥方法。 糖类与填充剂的比例和制剂的蛋白质浓度是影响冻干和储存期间填充剂结晶的重要因素，如一些加工条件。 在一个实施方案中，糖是二糖，例如蔗糖，结晶填充剂是甘露糖醇。 蛋白质可以是抗体或非抗体蛋白质。
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