公开(公告)号：US10377451B2

公开(公告)日：2019-08-13

申请号：US15708217

申请日：2017-09-19

Applicant: Robert D. Johnson

Inventor： Robert D. Johnson

IPC: B63B1/12 ,  B63B35/71

Abstract: A canoe and platform combination assembly includes a platform that has a top side, a bottom side, a front edge, a rear edge, a first lateral edge and a second lateral edge. A plurality of arms is attached to the platform. The arms engage canoes positioned adjacent to the first and second lateral sides such that the canoes are orientated parallel to each other. A plurality of tethers is provided. Each of the arms has one of the tethers positioned thereon. Each of the tethers is positioned around one of a plurality of braces of the canoes.

公开(公告)号：US20120065484A1

公开(公告)日：2012-03-15

申请号：US13292321

申请日：2011-11-09

Applicant: Edward L. Hull ,  Marwood Neal Ediger ,  Christopher D. Brown ,  John D. Maynard ,  Robert D. Johnson

Inventor： Edward L. Hull ,  Marwood Neal Ediger ,  Christopher D. Brown ,  John D. Maynard ,  Robert D. Johnson

IPC: A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/412 ,  A61B5/441

Abstract: A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise various light excitation and detection configurations. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method.

Abstract translation: 确定个体中组织状态（例如，糖基化终产物或疾病状态）的量度的方法。 用激发光照射个体组织的一部分，然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以包括各种光激发和检测配置。 本发明还可以包括校正技术，其减少由于检测除了组织中的化学物质的荧光以外的光的测定误差。 其他生物信息可与荧光性质结合使用，有助于测定组织状态。 本发明还包括适用于实施该方法的装置。

公开(公告)号：US08131332B2

公开(公告)日：2012-03-06

申请号：US11675524

申请日：2007-02-15

Applicant: John D Maynard ,  Marwood Neal Ediger ,  Robert D Johnson ,  Mark Ries Robinson

Inventor： John D Maynard ,  Marwood Neal Ediger ,  Robert D Johnson ,  Mark Ries Robinson

IPC: A61B5/1455

CPC classification number: A61B5/14532 ,  A61B5/0071 ,  A61B5/1455

Abstract: Embodiments of the present invention provide an apparatus suitable for determining properties of in vivo tissue from spectral information collected from various tissue sites. An illumination system provides light at a plurality of broadband ranges, which are communicated to an optical probe. The optical probe can be a flexible probe in some embodiments, allowing ease of application. Light homogenizers and mode scramblers can be employed to improve the performance in some embodiments. The optical probe in some embodiments physically contacts the tissue, and in some embodiments does not physically contact the tissue. The optical probe receives light from the illumination system and transmits it to tissue, and receives light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof. The optical probe can communicate the light to a spectrograph which produces a signal representative of the spectral properties of the light. An analysis system determines a property of the in vivo tissue from the spectral properties.

Abstract translation: 本发明的实施方案提供一种适合于从各种组织部位收集的光谱信息确定体内组织的性质的装置。 照明系统提供多个宽带范围的光，其传送到光学探针。 在一些实施例中，光学探针可以是柔性探针，允许易于应用。 在一些实施例中，可使用光均质器和模式加扰器来提高性能。 在一些实施例中，光学探针物理接触组织，并且在一些实施例中，物理接触组织。 光学探针从照明系统接收光并将其传输到组织，并且响应于宽带光或其组合而接收从体内组织发出的响应于通过其荧光发射的宽带光而漫反射的光。 光学探针可以将光传送到产生表示光的光谱特性的信号的光谱仪。 分析系统根据光谱性质确定体内组织的性质。

公开(公告)号：US08078243B2

公开(公告)日：2011-12-13

申请号：US11561380

申请日：2006-11-17

Applicant: Marwood Neal Ediger ,  John D Maynard ,  Robert D Johnson ,  Edward L Hull ,  Christopher D Brown

Inventor： Marwood Neal Ediger ,  John D Maynard ,  Robert D Johnson ,  Edward L Hull ,  Christopher D Brown

IPC: A61B5/1455

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/412 ,  A61B5/441

Abstract: A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of wavelengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.

Abstract translation: 确定个体中组织状态（例如，糖基化终产物或疾病状态）的量度的方法。 用激发光照射个体组织的一部分，然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以包括单波长激发光，激发光的扫描（以多个波长照射组织），单个波长的检测，检测波长的扫描（检测多个波长的发射光）及其组合。 本发明还可以包括校正技术，其减少由于检测到除了组织中的化学物质的荧光以外的光的测定误差。 例如，如果不采用适当的校正，组织的反射率可能导致错误。 本发明还可以包括将荧光与组织状态的测量相关联的各种模型，包括用于产生这种模型的各种方法。 其他生物信息可与荧光性质结合使用，有助于测定组织状态。 本发明还包括适于执行该方法的装置，包括用于检测荧光和组织状态测量的适当的光源，检测器和模型（例如，在计算机上实现）。

公开(公告)号：US20110184260A1

公开(公告)日：2011-07-28

申请号：US13036012

申请日：2011-02-28

Applicant: M. Ries Robinson ,  Russell E. Abbink ,  Robert D. Johnson

Inventor： M. Ries Robinson ,  Russell E. Abbink ,  Robert D. Johnson

IPC: A61B5/1455

CPC classification number: G01N21/21 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14558 ,  A61B5/7257 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0262 ,  G01N21/49 ,  G01N2021/4792

Abstract: The present invention provides methods and apparatuses for accurate noninvasive determination of tissue properties. Some embodiments of the present invention comprise an optical sampler having an illumination subsystem, adapted to communicate light having a first polarization to a tissue surface; a collection subsystem, adapted to collect light having a second polarization communicated from the tissue after interaction with the tissue; wherein the first polarization is different from the second polarization. The difference in the polarizations can discourage collection of light specularly reflected from the tissue surface, and can encourage preferential collection of light that has interacted with a desired depth of penetration or path length distribution in the tissue. The different polarizations can, as examples, be linear polarizations with an angle between, or elliptical polarizations of different handedness.

Abstract translation: 本发明提供用于精确无创确定组织性质的方法和装置。 本发明的一些实施例包括具有照明子系统的光学采样器，适于将具有第一偏振光的光传送到组织表面; 收集子系统，适于在与所述组织相互作用之后收集从所述组织传递的具有第二极化的光; 其中所述第一极化不同于所述第二极化。 极化的差异可以阻止从组织表面反射的光的收集，并且可以鼓励优先收集与组织中所需的穿透深度或路径长度分布相互作用的光。 作为示例，不同的极化可以是具有不同手性的角度或椭圆偏振之间的线性偏振。

公开(公告)号：US07139598B2

公开(公告)日：2006-11-21

申请号：US10972173

申请日：2004-10-22

Applicant: Edward L. Hull ,  Marwood Neal Ediger ,  Christopher D. Brown ,  John D. Maynard ,  Robert D. Johnson

Inventor： Edward L. Hull ,  Marwood Neal Ediger ,  Christopher D. Brown ,  John D. Maynard ,  Robert D. Johnson

IPC: A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/412 ,  A61B5/441

Abstract: A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of wavelengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.

Abstract translation: 确定个体中组织状态（例如，糖基化终产物或疾病状态）的量度的方法。 用激发光照射个体组织的一部分，然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。 检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。 本发明可以包括单波长激发光，激发光的扫描（以多个波长照射组织），单个波长的检测，检测波长的扫描（检测多个波长的发射光）及其组合。 本发明还可以包括校正技术，其减少由于检测到除了组织中的化学物质的荧光以外的光的测定误差。 例如，如果不采用适当的校正，组织的反射率可能导致错误。 本发明还可以包括将荧光与组织状态的测量相关联的各种模型，包括用于产生这种模型的各种方法。 其他生物信息可与荧光性质结合使用，有助于测定组织状态。 本发明还包括适于执行该方法的装置，包括用于检测荧光和组织状态测量的适当的光源，检测器和模型（例如，在计算机上实现）。

公开(公告)号：US07036008B2

公开(公告)日：2006-04-25

申请号：US10417994

申请日：2003-04-17

Applicant: Mukund Raghavachari ,  Robert D. Johnson ,  Darrell Christopher Reimer

Inventor： Mukund Raghavachari ,  Robert D. Johnson ,  Darrell Christopher Reimer

IPC: G06F9/00 ,  G06F9/24 ,  G06F15/177

CPC classification number: G06F9/44505

Abstract: A method for setting configuration parameters for at least one software system, comprises the steps of: a) receiving an identification of a set of configuration parameters for at least one software system to be optimized; b) selecting a random value from a predetermined range for each configuration parameter of interest; c) setting each configuration parameter to a corresponding random value selected; d) running an application using the values selected; e) gathering performance information relating to the software system while the application is running; f) repeating steps b) through e) for a selected number of times; and g) performing an analysis of the performance information gathered to determine optimal configuration parameters. The method can be performed by a programmable computer system running program instructions for carrying out the above method steps or by a specialized apparatus such as an ASIC.

Abstract translation: 一种用于设置至少一个软件系统的配置参数的方法，包括以下步骤：a）接收要优化的至少一个软件系统的一组配置参数的标识; b）从感兴趣的每个配置参数的预定范围中选择一个随机值; c）将每个配置参数设置为所选择的相应随机值; d）使用所选择的值运行应用程序; e）在应用程序运行时收集与软件系统相关的性能信息; f）重复步骤b）至e）选定次数; 以及g）对所收集的性能信息执行分析以确定最佳配置参数。 该方法可以通过执行用于执行上述方法步骤的程序指令的可编程计算机系统或者通过诸如ASIC的专门装置来执行。

公开(公告)号：US06983176B2

公开(公告)日：2006-01-03

申请号：US09832608

申请日：2001-04-11

Applicant: Craig Gardner ,  Michael J. Haass ,  Robert K. Rowe ,  Howland Jones ,  Steven T. Strohl ,  Matthew J. Novak ,  Russell E. Abbink ,  David Nuñez ,  William Gruner ,  Robert D. Johnson

Inventor： Craig Gardner ,  Michael J. Haass ,  Robert K. Rowe ,  Howland Jones ,  Steven T. Strohl ,  Matthew J. Novak ,  Russell E. Abbink ,  David Nuñez ,  William Gruner ,  Robert D. Johnson

IPC: A61B5/00

CPC classification number: G01N21/278 ,  A61B5/0075

Abstract: Systems and methods for establishing and/or maintaining the prediction capability over time of a multivariate calibration model designed for quantitative optical spectroscopic measurement of attributes or analytes in bodily tissues, bodily fluids or other biological samples, which are particularly useful when the spectral absorbance of the attribute or analyte is small relative to the background. The present invention provides an optically similar reference sample to capture the characteristics of instrument and environmental variation and to reduce the effect of such variation on the measurement capability of the model. The optically similar reference is preferably stable over time and is designed such that its optical properties are sufficiently matched to the sample of interest that instrument and environmental variations are captured in the same manner in both the test sample of interest and the optically similar reference sample. The optically similar reference sample may include one or more physical components which are spectroscopically measured in a manner which closely mimics the spectroscopic measurement of the test sample of interest. Spectral similarity may also be achieved by using alternative components with spectral characteristics similar to the components contained in the test sample of interest.

公开(公告)号：US06888341B2

公开(公告)日：2005-05-03

申请号：US10662523

申请日：2003-09-16

Applicant: Robert D. Johnson ,  Mark R. Schaefer ,  Daniel Mieczkowski

Inventor： Robert D. Johnson ,  Mark R. Schaefer ,  Daniel Mieczkowski

IPC: G01R1/067 ,  G01R19/165 ,  G01R19/14

CPC classification number: G01R1/06788 ,  G01R19/16561

Abstract: A handheld dual voltage circuit tester, method and electronic circuit that quickly allows a technician to determine whether an automotive electrical system runs on a 12-14 volt circuit or 36-42 volt circuit. The tester may be used for automobiles having a single voltage electrical system, or automobiles with distinct electrical systems operating on one of a 12-14 volts circuit or a 36-42 volt circuit. The tester includes a screwdriver-type elongated handle and probe tip. The tester also includes electronic circuitry disposed within its handle, heat shrink tubing, a conductive spring assembly, a strain relief, a retractable coil cord, a ground clip and insulation that encloses the ground clip. The tester also includes electronic circuitry that emits light of a first color when a 12-14 volt circuit is sensed, and light of a second color when a 36-42 volt circuit is sensed.

Abstract translation: 一种手持式双电压电路测试仪，方法和电子电路，可快速使技术人员确定汽车电气系统是否运行在12-14伏特电路或36-42伏特电路上。 测试仪可以用于具有单电压电气系统的汽车，或者具有在12-14伏电路或36-42伏特电路之一上工作的不同电气系统的汽车。 测试仪包括螺丝刀型细长手柄和探头。 测试仪还包括设置在其手柄内的电子电路，热收缩管，导电弹簧组件，应变消除件，可伸缩线圈绳索，接地夹子和封闭接地夹子的绝缘体。 当检测到12-14伏电路时，测试仪还包括发射第一种颜色的光的电子电路，以及当感测到36-42伏特电路时，第二种颜色的光。

公开(公告)号：US06865408B1

公开(公告)日：2005-03-08

申请号：US10378237

申请日：2003-03-03

Applicant: Russell E. Abbink ,  Robert D. Johnson ,  John D. Maynard

Inventor： Russell E. Abbink ,  Robert D. Johnson ,  John D. Maynard

IPC: A61B5/00 ,  G01J3/02 ,  G01J3/10 ,  G01N21/27 ,  G01N21/47 ,  G01N21/49 ,  G01N33/487 ,  G02B6/42 ,  G02B27/00

CPC classification number: G02B6/4298 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1455 ,  G01J3/02 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/10 ,  G01N21/278 ,  G01N21/4785 ,  G01N21/49 ,  G01N2201/1293 ,  G02B6/4206

Abstract: An apparatus and method for non-invasive measurement of glucose in human tissue by quantitative infrared spectroscopy to clinically relevant levels of precision and accuracy. The system includes six subsystems optimized to contend with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The six subsystems include an illumination subsystem, a tissue sampling subsystem, a calibration maintenance subsystem, an FTIR spectrometer subsystem, a data acquisition subsystem, and a computing subsystem.

Abstract translation: 一种用于通过定量红外光谱对人体组织中葡萄糖进行非侵入性测量的临床相关水平的精确度和准确度的装置和方法。 该系统包括六个子系统，优化以应对组织光谱的复杂性，高信噪比和光度精度要求，组织采样误差，校准维护问题和校准转移问题。 六个子系统包括照明子系统，组织采样子系统，校准维护子系统，FTIR光谱仪子系统，数据采集子系统和计算子系统。