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    Functionalization of nanofluidic channels
    2.
    发明授权
    Functionalization of nanofluidic channels 有权
    纳米流体通道的功能化

    公开(公告)号：US08440453B2

    公开(公告)日：2013-05-14

    申请号：US11969010

    申请日：2008-01-03

    Applicant: Peidong Yang ,  Rohit Karnik ,  Kenneth Castelino ,  Rong Fan ,  Arun Majumdar

    Inventor： Peidong Yang ,  Rohit Karnik ,  Kenneth Castelino ,  Rong Fan ,  Arun Majumdar

    IPC: C12M3/00

    CPC classification number: G01N33/54373

    Abstract: A functionalized nanofluidic channel and method for functionalization that provides control over the ionic environment and geometry of the nanofluidic channel with the immobilization of biomolecules on the inner surface of the channel and use of high ionic concentration solutions. In one embodiment, the surface charge of the nanochannel is controlled with the immobilization of a protein such as streptavidin in the nanochannel. In another embodiment, the biomolecules are receptors and changes in nanochannel conductance indicates ligand binding events. The functionalized nanofluidic channel can be easily adapted for use with microchannel arrays.

    Abstract translation: 功能化纳米流体通道和功能化方法，其通过在通道的内表面上固定生物分子并使用高离子浓度溶液来提供对纳米流体通道的离子环境和几何形状的控制。 在一个实施方案中，通过在纳米通道中固定蛋白质例如链霉亲和素来控制纳米通道的表面电荷。 在另一个实施方案中，生物分子是受体，并且纳米通道电导的变化表示配体结合事件。 功能化纳米流体通道可以容易地适用于微通道阵列。

    NANOTUBES AND DEVICES FABRICATED THEREFROM
    3.
    发明申请
    NANOTUBES AND DEVICES FABRICATED THEREFROM 有权

    公开(公告)号：US20090283751A1

    公开(公告)日：2009-11-19

    申请号：US12335430

    申请日：2008-12-15

    Applicant: Peidong Yang ,  Arunava Majumdar ,  Rong Fan ,  Rohit Karnik

    Inventor： Peidong Yang ,  Arunava Majumdar ,  Rong Fan ,  Rohit Karnik

    IPC: H01L29/66 ,  G01N27/00

    CPC classification number: H01L29/775 ,  B82Y10/00 ,  G01N27/4145 ,  G01N27/4146 ,  H01L29/0673

    Abstract: Nanofluidic devices incorporating inorganic nanotubes fluidly coupled to channels or nanopores for supplying a fluid containing chemical or biochemical species are described. In one aspect, two channels are fluidly interconnected with a nanotube. Electrodes on opposing sides of the nanotube establish electrical contact with the fluid therein. A bias current is passed between the electrodes through the fluid, and current changes are detected to ascertain the passage of select molecules, such as DNA, through the nanotube. In another aspect, a gate electrode is located proximal the nanotube between the two electrodes thus forming a nanofluidic transistor. The voltage applied to the gate controls the passage of ionic species through the nanotube selected as either or both ionic polarities. In either of these aspects the nanotube can be modified, or functionalized, to control the selectivity of detection or passage.

    Abstract translation: 描述了纳入流体耦合到通道或纳米孔的无机纳米管的纳米流体装置，用于提供含有化学或生化物质的流体。 在一个方面，两个通道与纳米管流体互连。 在纳米管的相对侧上的电极与其中的流体建立电接触。 通过流体在电极之间通过偏置电流，并且检测电流变化以确定通过纳米管的选择分子例如DNA的通过。 在另一方面，栅极位于两个电极之间的纳米管附近，从而形成纳米流体晶体管。 施加到栅极的电压控制离子物质通过通过选择为离子极性之一或两者的纳米管的通过。 在这些方面的任一个中，可以修饰或官能化纳米管以控制检测或通过的选择性。

    NANOSTRUCTURED MICRO HEAT PIPES
    4.
    发明申请
    NANOSTRUCTURED MICRO HEAT PIPES 审中-公开
    纳米微管热管

    公开(公告)号：US20090056917A1

    公开(公告)日：2009-03-05

    申请号：US12063226

    申请日：2006-08-09

    Applicant: Arun Majumdar ,  Rohit Karnik ,  Woochul Kim

    Inventor： Arun Majumdar ,  Rohit Karnik ,  Woochul Kim

    IPC: F28F13/02 ,  F28F13/18 ,  F28D15/02

    CPC classification number: F28D15/046 ,  F28D15/0233 ,  F28D2015/0225 ,  H01L23/427 ,  H01L2924/0002 ,  H01L2924/00

    Abstract: A heat pipe comprising a chamber; a wick in the chamber, and a heat sink, which is adjacent to a first portion of the wick. A heat source adjacent to a second portion of the wick, wherein the wick is configured such that a gas condenses at the first portion of the wick and a liquid evaporates at the second portion of the wick. The fluid moves from the first portion of the wick to the second portion of the wick, and wherein the wick comprises nanostructures having a differentially-spaced apart gradient along the length of the wick so as to promote capillary fluid flow therealong.

    Abstract translation: 一种包括腔室的热管; 腔室中的灯芯和与灯芯的第一部分相邻的散热器。 与所述芯的第二部分相邻的热源，其中所述芯被构造成使得气体在所述芯的第一部分处冷凝，并且液体在所述芯的第二部分处蒸发。 流体从芯的第一部分移动到芯的第二部分，并且其中芯包括沿着芯的长度具有差异间隔开的梯度的纳米结构，以便促进毛细管流体沿其流动。

    FUNCTIONALIZATION OF NANOFLUIDIC CHANNELS
    5.
    发明申请
    FUNCTIONALIZATION OF NANOFLUIDIC CHANNELS 有权
    纳米通道的功能化

    公开(公告)号：US20120171778A1

    公开(公告)日：2012-07-05

    申请号：US11969010

    申请日：2008-01-03

    Applicant: Peidong Yang ,  Rohit Karnik ,  Kenneth Castelino ,  Rong Fan ,  Arun Majumdar

    Inventor： Peidong Yang ,  Rohit Karnik ,  Kenneth Castelino ,  Rong Fan ,  Arun Majumdar

    IPC: G01N27/00 ,  B82Y15/00

    CPC classification number: G01N33/54373

    Abstract: A functionalized nanofluidic channel and method for functionalization that provides control over the ionic environment and geometry of the nanofluidic channel with the immobilization of biomolecules on the inner surface of the channel and use of high ionic concentration solutions. In one embodiment, the surface charge of the nanochannel is controlled with the immobilization of a protein such as streptavidin in the nanochannel. In another embodiment, the biomolecules are receptors and changes in nanochannel conductance indicates ligand binding events. The functionalized nanofluidic channel can be easily adapted for use with microchannel arrays.

    Abstract translation: 功能化纳米流体通道和功能化方法，其通过在通道的内表面上固定生物分子并使用高离子浓度溶液来提供对纳米流体通道的离子环境和几何形状的控制。 在一个实施方案中，通过在纳米通道中固定蛋白质例如链霉亲和素来控制纳米通道的表面电荷。 在另一个实施方案中，生物分子是受体，并且纳米通道电导的变化表示配体结合事件。 功能化纳米流体通道可以容易地适用于微通道阵列。

    Inorganic nanotubes and electro-fluidic devices fabricated therefrom
    6.
    发明授权
    Inorganic nanotubes and electro-fluidic devices fabricated therefrom 有权
    无机纳米管和由其制造的电流装置

    公开(公告)号：US07898005B2

    公开(公告)日：2011-03-01

    申请号：US12335430

    申请日：2008-12-15

    Applicant: Peidong Yang ,  Arunava Majumdar ,  Rong Fan ,  Rohit Karnik

    Inventor： Peidong Yang ,  Arunava Majumdar ,  Rong Fan ,  Rohit Karnik

    IPC: G01N27/447

    CPC classification number: H01L29/775 ,  B82Y10/00 ,  G01N27/4145 ,  G01N27/4146 ,  H01L29/0673

    Abstract: Nanofluidic devices incorporating inorganic nanotubes fluidly coupled to channels or nanopores for supplying a fluid containing chemical or bio-chemical species are described. In one aspect, two channels are fluidly interconnected with a nanotube. Electrodes on opposing sides of the nanotube establish electrical contact with the fluid therein. A bias current is passed between the electrodes through the fluid, and current changes are detected to ascertain the passage of select molecules, such as DNA, through the nanotube. In another aspect, a gate electrode is located proximal the nanotube between the two electrodes thus forming a nanofluidic transistor. The voltage applied to the gate controls the passage of ionic species through the nanotube selected as either or both ionic polarities. In either of these aspects the nanotube can be modified, or functionalized, to control the selectivity of detection or passage.

    Abstract translation: 描述了纳入流体耦合到通道或纳米孔的无机纳米管的纳米流体装置，用于供应含有化学或生物化学物质的流体。 在一个方面，两个通道与纳米管流体互连。 在纳米管的相对侧上的电极与其中的流体建立电接触。 通过流体在电极之间通过偏置电流，并且检测电流变化以确定通过纳米管的选择分子例如DNA的通过。 在另一方面，栅极位于两个电极之间的纳米管附近，从而形成纳米流体晶体管。 施加到栅极的电压控制离子物质通过通过选择为离子极性之一或两者的纳米管的通过。 在这些方面的任一个中，可以修饰或官能化纳米管以控制检测或通过的选择性。

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