公开(公告)号：US07638518B2

公开(公告)日：2009-12-29

申请号：US11871444

申请日：2007-10-12

Applicant: George Chiu ,  Yang Yu ,  Ronghui Lin ,  Shengjian Li ,  Peter J. Connolly

Inventor： George Chiu ,  Yang Yu ,  Ronghui Lin ,  Shengjian Li ,  Peter J. Connolly

IPC: A61K31/469 ,  C07D401/14 ,  A61P17/00 ,  A61P25/28 ,  A61P35/00 ,  A61P27/02 ,  A61P25/16 ,  A61P17/06 ,  A61K31/4439

CPC classification number: C07D401/14

Abstract: The present invention is directed to novel substituted pyrazole compounds of Formula (I) or a form or composition thereof and the use thereof as inhibitors of ATP-protein kinase interactions.

Abstract translation: 本发明涉及式（I）的新型取代吡唑化合物或其形式或组成，以及作为ATP-蛋白激酶相互作用抑制剂的用途。

公开(公告)号：US07579356B2

公开(公告)日：2009-08-25

申请号：US11401339

申请日：2006-04-10

Applicant: Kathleen A. Battista ,  Gilles C. Bignan ,  Peter J. Connolly ,  Stuart Hayden ,  Sigmond G. Johnson ,  Ronghui Lin ,  Niranjan B. Pandey ,  Mark T. Powell

Inventor： Kathleen A. Battista ,  Gilles C. Bignan ,  Peter J. Connolly ,  Stuart Hayden ,  Sigmond G. Johnson ,  Ronghui Lin ,  Niranjan B. Pandey ,  Mark T. Powell

IPC: A01N43/54 ,  A61K31/515 ,  C07D239/00 ,  C07D471/00 ,  C07D487/00 ,  C07D491/00

CPC classification number: C07D495/16

Abstract: The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.

Abstract translation: 本发明涉及式（I）的新型硫代四氮杂苊烯化合物及其药学上可接受的形式，以及它们作为ATP-蛋白激酶相互作用抑制剂的合成和用途。

公开(公告)号：US20090048249A1

公开(公告)日：2009-02-19

申请号：US11443994

申请日：2006-05-31

Applicant: George Chiu ,  Peter J. Connolly ,  Stuart Emanuel ,  Shenlin Huang ,  Shengjian Li ,  Ronghui Lin ,  Yanhua Lu ,  Steven A. Middleton

Inventor： George Chiu ,  Peter J. Connolly ,  Stuart Emanuel ,  Shenlin Huang ,  Shengjian Li ,  Ronghui Lin ,  Yanhua Lu ,  Steven A. Middleton

IPC: A61K31/5377 ,  C07D471/02 ,  A61K31/437 ,  A61K31/496 ,  C12N9/99 ,  A61P3/00 ,  A61P25/00 ,  A61P9/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  A61P19/02 ,  A61K31/506 ,  C07D401/14 ,  C07D413/14

CPC classification number: C07D471/04

Abstract: The present invention is directed to novel 3-benzoimidazolyl-pyrazolopyridine compounds of formula (I): and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of serine-threonine protein kinases and tyrosine protein kinases and interactions thereof.

Abstract translation: 本发明涉及式（I）的新的3-苯并咪唑基 - 吡唑并吡啶化合物及其药学上可接受的形式，以及它们作为丝氨酸 - 苏氨酸蛋白激酶和酪氨酸蛋白激酶及其相互作用的抑制剂的合成和用途。

公开(公告)号：US20080103172A1

公开(公告)日：2008-05-01

申请号：US11871463

申请日：2007-10-12

Applicant: Yang YU ,  Ronghui Lin ,  Peter Connolly

Inventor： Yang YU ,  Ronghui Lin ,  Peter Connolly

IPC: A61K31/4725 ,  C07D401/14 ,  A61K31/4439 ,  A61P25/28 ,  A61P3/10 ,  C07D217/02

CPC classification number: C07D401/14

Abstract: The present invention is directed to novel substituted pyrazole compounds of Formula (I) or a form or composition thereof and the use thereof as inhibitors of ATP-protein kinase interactions.

Abstract translation: 本发明涉及式（I）的新型取代吡唑化合物或其形式或组成，以及作为ATP-蛋白激酶相互作用抑制剂的用途。

公开(公告)号：US20060173020A1

公开(公告)日：2006-08-03

申请号：US11245314

申请日：2005-10-06

Applicant: Shenlin Huang ,  Ronghui Lin ,  Peter Connolly ,  Stuart Emanuel ,  Steven Middleton ,  Robert Gruninger ,  Steven Wetter

Inventor： Shenlin Huang ,  Ronghui Lin ,  Peter Connolly ,  Stuart Emanuel ,  Steven Middleton ,  Robert Gruninger ,  Steven Wetter

IPC: A61K31/497 ,  A61K31/4439 ,  A61K31/4196 ,  C07D249/14 ,  C07D403/02

CPC classification number: C07D403/12 ,  C07D249/14

Abstract: 1,2,4-Triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I), pharmaceutically acceptable salts thereof, processes for the manufacture of 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives and pharmaceutical compositions containing 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives are disclosed: The 1,2,4-triazolylaminoaryl(heteroaryl)sulfonamide derivatives of formula (I) possess cell cycle inhibitory activity and are accordingly useful for their anti cell proliferation (such as anti cancer) activity.

Abstract translation: 式（I）的1,2,4-三唑基氨基芳基（杂芳基）磺酰胺衍生物，其药学上可接受的盐，制备1,2,4-三唑基氨基芳基（杂芳基）磺酰胺衍生物的方法和含有1,2,4-三唑基氨基芳基 三唑基氨基芳基（杂芳基）磺酰胺衍生物：式（I）的1,2,4-三唑基氨基芳基（杂芳基）磺酰胺衍生物具有细胞周期抑制活性，因此可用于其抗细胞增殖（如抗癌）活性。

公开(公告)号：US20050182116A1

公开(公告)日：2005-08-18

申请号：US11047800

申请日：2005-02-01

Applicant: Ronghui Lin ,  Shenlin Huang ,  Steven Wetter ,  Peter Connolly ,  Stuart Emanuel ,  Robert Gruninger ,  Steven Middleton

Inventor： Ronghui Lin ,  Shenlin Huang ,  Steven Wetter ,  Peter Connolly ,  Stuart Emanuel ,  Robert Gruninger ,  Steven Middleton

IPC: A61K31/4178 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/4439 ,  C07D249/14 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D417/06 ,  C07D249/08 ,  C07D43/02

CPC classification number: C07D401/06 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/4439 ,  C07D249/14 ,  C07D405/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D417/06

Abstract: The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder.

公开(公告)号：US20160016942A1

公开(公告)日：2016-01-21

申请号：US14772040

申请日：2014-03-13

Applicant: Jie CHEN ,  Matthew DONAHUE ,  Heng-Keang LIM ,  Ronghui LIN ,  Rhys SALTER ,  Jiejun WU ,  JANSSEN PHARMACEUTICA NV

Inventor： Jie CHEN ,  Matthew DONAHUE ,  Heng-Keeng LIM ,  Ronghui LIN ,  Rhys SALTER ,  Jiejun WU

IPC: C07D405/14

CPC classification number: C07D405/14

Abstract: The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.

Abstract translation: 本发明涉及取代的吡啶衍生物，含有所述衍生物的药物组合物和所述衍生物在治疗由c-fms激酶介导的病症中的用途。 本发明进一步涉及制备所述取代的吡啶衍生物的方法。

公开(公告)号：US20090076037A1

公开(公告)日：2009-03-19

申请号：US11858609

申请日：2007-09-20

Applicant: Peter J. Connolly ,  Stuart Emanuel ,  Ronghui Lin ,  Yanhua Lu ,  Steven A. Middleton

Inventor： Peter J. Connolly ,  Stuart Emanuel ,  Ronghui Lin ,  Yanhua Lu ,  Steven A. Middleton

IPC: A61K31/519 ,  C07D487/04 ,  A61P35/02 ,  A61P35/00 ,  A61P25/28 ,  A61P17/00

CPC classification number: C07D487/04 ,  C07D498/04

Abstract: The present invention is directed to novel bicyclic pyrimidine compounds of Formula (I) or a form or composition thereof and the use thereof as inhibitors of ATP-protein kinase interactions.

Abstract translation: 本发明涉及式（I）的新型双环嘧啶化合物或其形式或组合物及其作为ATP-蛋白激酶相互作用抑制剂的用途。

公开(公告)号：US20080108611A1

公开(公告)日：2008-05-08

申请号：US11621610

申请日：2007-01-10

Applicant: Kathleen A. Battista ,  Gilles C. Bignan ,  Peter J. Connolly ,  Stuart L. Emanuel ,  Stuart Hayden ,  Sigmond G. Johnson ,  Ronghui Lin ,  Steven A. Middleton ,  Niranjan B. Pandey ,  Mark T. Powell

Inventor： Kathleen A. Battista ,  Gilles C. Bignan ,  Peter J. Connolly ,  Stuart L. Emanuel ,  Stuart Hayden ,  Sigmond G. Johnson ,  Ronghui Lin ,  Steven A. Middleton ,  Niranjan B. Pandey ,  Mark T. Powell

IPC: A61K31/519 ,  C07D495/04 ,  A61K31/5377 ,  A61P35/00 ,  A61P17/00 ,  A61P9/00 ,  C07D413/14

CPC classification number: C07D495/04

Abstract: The present invention is directed to thienopyrimidine compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.

Abstract translation: 本发明涉及式（I）的噻吩并嘧啶化合物及其形式，其合成和用途，用于治疗，预防或改善慢性或急性蛋白激酶介导的疾病，病症或病症。

公开(公告)号：US20070265264A1

公开(公告)日：2007-11-15

申请号：US11401339

申请日：2006-04-10

Applicant: Kathleen Battista ,  Gilles Bignan ,  Peter Connolly ,  Stuart Hayden ,  Sigmond Johnson ,  Ronghui Lin ,  Niranjan Pandey ,  Mark Powell

Inventor： Kathleen Battista ,  Gilles Bignan ,  Peter Connolly ,  Stuart Hayden ,  Sigmond Johnson ,  Ronghui Lin ,  Niranjan Pandey ,  Mark Powell

IPC: A61K31/505 ,  A61K31/5377 ,  A61P19/02 ,  A61P19/08 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P31/12 ,  A61P35/00 ,  A61P9/10 ,  C07D239/00 ,  C07D413/14

CPC classification number: C07D495/16

Abstract: The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.

Abstract translation: 本发明涉及式（I）的新型硫代四氮杂苊烯化合物及其药学上可接受的形式，以及它们作为ATP-蛋白激酶相互作用抑制剂的合成和用途。