-
公开(公告)号：US20190383821A1
公开(公告)日：2019-12-19
申请号：US16486723
申请日：2018-02-19
Applicant: MITSUI CHEMICALS, INC. , NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION , SAVID THERAPEUTICS INC.
Inventor： Tsuneji SUZUKI , Yoshiyuki TOTANI , Kosuke MANO , Shinichi BANBA , Haruhiko KAMADA , Taisuke NAKAYAMA , Hiroki AKIBA , Kouhei TSUMOTO , Tsuyoshi INOUE
IPC: G01N33/58 , G01N33/68 , C07K16/28 , C07D495/04 , C07K14/36 , C07D519/00
Abstract: Finding a protein of a minute amount present on a cell membrane to provide a method for producing an antibody against the protein. Producing an antibody using a protein identified by an identification method including: a labeling step of using a labeling agent comprising at least one selected from bis-iminobiotin compounds and bis-biotin compounds to obtain cells having a labeled protein; a degradation step of preparing a degradation product for an immobilization treatment, the degradation product containing the labeled protein; an immobilization step of immobilizing the labeled protein contained in the degradation product for an immobilization treatment on a stationary phase via a streptavidin mutant; a cleavage step of releasing an analysis sample from the stationary phase on which the labeled protein is immobilized; and an analysis step of analyzing the analysis sample to identify the labeled protein.
-
公开(公告)号：US20230149558A1
公开(公告)日：2023-05-18
申请号：US17920461
申请日：2021-04-23
Applicant: The University of Tokyo , SAVID THERAPEUTICS INC. , TOHOKU UNIVERSITY
Inventor： Motomu KANAI , Kenzo YAMATSUGU , Toshifumi TATSUMI , Tatsuhiko KODAMA , Akira SUGIYAMA , Masanobu TSUKAGOSHI , Hidetoshi TOKUYAMA , Juri SAKATA
CPC classification number: A61K47/6898 , A61K47/545
Abstract: It is an object of the present invention to provide a conjugate of a duocarmycin derivative and a biotin-modified dimer, which is useful for pretargeting methods. According to the present invention, a compound represented by the following formula (1) or formula (2) is provided:
wherein R1 and R2 each independently represent a hydrogen atom, a lower alkyl group, or a lower alkoxycarbonyl group; one of R3, R4, and R5 represents —O-L7-(Xaa)m-L6-N3, and the remaining two each independently represent a hydrogen atom, a lower alkyl group, or a lower alkoxycarbonyl group; X represents a reactive group; L6 and L7 each independently represent a divalent linking group; Xaa represents an amino acid residue; m represents an integer of 2 to 10; and Me represents a methyl group.-
公开(公告)号：US11286285B2
公开(公告)日：2022-03-29
申请号：US15119441
申请日：2015-02-18
Applicant: SAVID THERAPEUTICS INC.
Inventor： Akira Sugiyama , Hirofumi Doi , Tatsuhiko Kodama , Tsuyoshi Inoue , Eiichi Mizohata , Tatsuya Kawato , Tomohiro Meshizuka , Motomu Kanai , Yohei Shimizu , Noriaki Takasu , Mari Takatsu
IPC: A61B5/00 , A61B8/00 , A61B10/00 , C07K14/36 , A61K49/00 , C07D519/00 , C07D495/04 , C07K16/22 , C07K16/28 , C09B23/10 , C07K14/00 , A61K49/10
Abstract: An object of this invention is to provide a streptavidin mutant reduced in affinity to the naturally-occurring biotin, and to provide a modified biotin which shows a high affinity to such streptavidin mutant reduced in affinity to the naturally-occurring biotin. This invention can provide a compound composed of a dimer of modified biotin, a streptavidin mutant, and usage of them.
-
公开(公告)号：US20210030882A1
公开(公告)日：2021-02-04
申请号：US17042534
申请日：2019-03-29
Applicant: Mitsui Chemicals, Inc. , The University of Tokyo , Savid Therapeutics Inc.
Inventor： Tsuneji SUZUKI , Kosuke MANO , Yoshiyuki TOTANII , Yohei SHIMIZU , Akira SUGIYAMA , Masanobu TSUKAGOSHI
Abstract: A bis-iminobiotin compound which has a structure that enables the easy bonding of a bis-iminobiotin moiety to a drug or a fluorescent compound and is useful for the delivery of a drug to a streptavidin-labeled substance. The bis-iminobiotin compound is represented by general formula 9. In the formula, A, D and E independently represent a spacer capable of bonding two bicyclo rings to each other, wherein E represents a structure that may be branched, each of A, D and E may have a substituent, and A, D and E may together form a cyclic structure; J represents a functional group for achieving a click reaction; G represents a spacer capable of bonding E to J; and R represents a hydrogen atom, an acetyl group, a benzyl group, a trifluoroacetyl group or a Boc group.
-
公开(公告)号：US12083183B2
公开(公告)日：2024-09-10
申请号：US17237709
申请日：2021-04-22
Applicant: THE UNIVERSITY OF TOKYO , SAVID THERAPEUTICS INC.
Inventor： Motomu Kanai , Kenzo Yamatsugu , Toshifumi Tatsumi , Kazuki Takahashi , Tatsuhiko Kodama , Akira Sugiyama , Takefumi Yamashita , Masanobu Tsukagoshi , Yuzo Toda , Junji Nishigaki
IPC: A61K47/64 , A61K31/4188 , A61K47/68
CPC classification number: A61K47/64 , A61K31/4188 , A61K47/6803
Abstract: [Object] It is an object of the present invention to provide a conjugate of a biotin-modified dimer and a phthalocyanine dye, which is used in photoimmunotherapy.
[Means for Solution] A compound represented by the following formula (1) or a salt thereof:
wherein X represents a substituent having a hydrophilic group, a cationic group or an amino group at the terminus thereof, or —OH, and other groups have the meanings as defined in the description.-
Patent Agency Ranking
公开(公告)号：US20220073641A1
公开(公告)日：2022-03-10
申请号：US17418475
申请日：2019-12-27
Applicant: The University of Tokyo , SAVID THERAPEUTICS INC.
Inventor： Toshiya TANAKA , Tatsuhiko KODAMA , Takefumi YAMASHITA , Motomu KANAI , Kenzo YAMATSUGU , Toshifumi TATSUMI , Kazuki TAKAHASHI , Shumpei ISHIKAWA , Akira SUGIYAMA , Masanobu TSUKAGOSHI
Abstract: It is an object of the present invention to provide a fusion protein of an antibody that recognizes cancer cells and a mutant streptavidin, which is for use in the treatment or diagnosis of cancer. According to the present invention, provided is a fusion protein having the amino acid sequence as set forth in SEQ ID NO: 2 or SEQ ID NO: 7, a linker sequence, and the amino acid sequence as set forth in SEQ ID NO: 1 (provided that the amino acid sequence portion consisting of 6 histidine residues at the C-terminus thereof may be partially or entirely deleted), from the N-terminal side to the C-terminal side, in this order.
-
公开(公告)号：US20220016245A1
公开(公告)日：2022-01-20
申请号：US17266190
申请日：2019-08-08
Applicant: The University of Tokyo , SAVID THERAPEUTICS INC.
Inventor： Motomu KANAI , Kenzo YAMATSUGU , Toshifumi TATSUMI , Kazuki TAKAHASHI , Tatsuhiko KODAMA , Toshiya TANAKA , Takefumi YAMASHITA , Akira SUGIYAMA , Masanobu TSUKAGOSHI
Abstract: It is an object of the present invention to provide a conjugate of a biotin-modified dimer and a phthalocyanine dye, which is used in photoimmunotherapy. The present invention provides a conjugate of a compound represented by the following formula (1) or a salt thereof and a phthalocyanine dye: wherein the meaning of each of symbols is as defined in the specification.
-
公开(公告)号：US09670255B2
公开(公告)日：2017-06-06
申请号：US14768916
申请日：2014-02-18
Applicant: SAVID THERAPEUTICS INC.
Inventor： Akira Sugiyama , Hirofumi Doi , Tatsuhiko Kodama , Tsuyoshi Inoue , Eiichi Mizohata , Tatsuya Kawato , Tomohiro Meshizuka , Motomu Kanai , Yohei Shimizu , Tomohiro Yamamoto
IPC: C07K14/36 , C07D495/04 , C07D497/04 , C07D498/04 , G01N33/543
CPC classification number: C07K14/36 , C07D495/04 , C07D497/04 , C07D498/04 , G01N33/54306 , G01N2333/36
Abstract: It is an object of the present invention to provide a mutant streptavidin with a reduced affinity for natural biotin, and also to provide a modified biotin having a high affinity for the mutant streptavidin with a reduced affinity for natural biotin. According to the present invention, there is provided a reagent kit for use in treatments or diagnoses, which comprises: (a) a mutant streptavidin with a reduced affinity for natural biotin or biocytin; and a modified biotin having a high affinity for the above-described mutant streptavidin.
-
公开(公告)号：US20170145063A1
公开(公告)日：2017-05-25
申请号：US15119441
申请日：2015-02-18
Applicant: SAVID THERAPEUTICS INC.
Inventor： Akira SUGIYAMA , Hirofumi DOI , Tatsuhiko KODAMA , Tsuyoshi INOUE , Eiichi MIZOHATA , Tatsuya KAWATO , Tomohiro MESHIZUKA , Motomu KANAI , Yohei SHIMIZU , Noriaki TAKASU , Mari TAKATSU
CPC classification number: C07K14/36 , A61K49/0032 , A61K49/0052 , A61K49/0058 , C07D495/04 , C07D519/00 , C07K16/22 , C07K16/2887 , C07K2317/24 , C07K2317/622 , C07K2319/21 , C07K2319/22 , C07K2319/33 , C09B23/107
Abstract: An object of this invention is to provide a streptavidin mutant reduced in affinity to the naturally-occurring biotin, and to provide a modified biotin which shows a high affinity to such streptavidin mutant reduced in affinity to the naturally-occurring biotin. This invention can provide a compound composed of a dimer of modified biotin, a streptavidin mutant, and usage of them.
-
公开(公告)号：US12115223B2
公开(公告)日：2024-10-15
申请号：US17237709
申请日：2021-04-22
Applicant: THE UNIVERSITY OF TOKYO , SAVID THERAPEUTICS INC.
Inventor： Motomu Kanai , Kenzo Yamatsugu , Toshifumi Tatsumi , Kazuki Takahashi , Tatsuhiko Kodama , Akira Sugiyama , Takefumi Yamashita , Masanobu Tsukagoshi , Yuzo Toda , Junji Nishigaki
IPC: A61K47/64 , A61K31/4188 , A61K47/68
CPC classification number: A61K47/64 , A61K31/4188 , A61K47/6803
Abstract: [Object] It is an object of the present invention to provide a conjugate of a biotin-modified dimer and a phthalocyanine dye, which is used in photoimmunotherapy.
[Means for Solution] A compound represented by the following formula (1) or a salt thereof:
wherein X represents a substituent having a hydrophilic group, a cationic group or an amino group at the terminus thereof, or —OH, and other groups have the meanings as defined in the description.
-
-
-
-
-
-
-
-
-
Search Results
24
records
(took 0.019 seconds)
