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公开(公告)号：US09587292B2
公开(公告)日：2017-03-07
申请号：US12588030
申请日：2009-10-01
Applicant: Suzanne Lapi , Thomas J. Ruth , Dirk W. Becker , John M. D'Auria
Inventor： Suzanne Lapi , Thomas J. Ruth , Dirk W. Becker , John M. D'Auria
CPC classification number: C22B34/34 , B01J19/081 , C22B7/002 , G21G1/001 , G21G2001/0036 , Y02P10/212
Abstract: A method of isolating 99Mo produced using a (n,γ) reaction according to example embodiments may include vaporizing a source compound containing 98Mo and 99Mo. The vaporized source compound may be ionized to form ions containing 98Mo and 99Mo. The ions may be separated to isolate the ions containing 99Mo. The isolated ions containing 99Mo may be collected with a collector. Accordingly, the isolated 99Mo may have a relatively high specific radioactivity and, in turn, may be used to produce the diagnostic radioisotope, 99mTc, through radioactive decay.
Abstract translation: 根据实施例的使用（n，γ）反应分离的99Mo的分离方法可以包括蒸发含有98Mo和99Mo的源化合物。 蒸发的源化合物可以被离子化以形成含有98Mo和99Mo的离子。 可以分离离子以分离含有99Mo的离子。 含有99Mo的离子离子可以用收集器收集。 因此，分离的99Mo可以具有相对较高的比放射性，并且依次可以通过放射性衰变来产生99m Tc的诊断放射性同位素。
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公开(公告)号：US07708961B2
公开(公告)日：2010-05-04
申请号：US12078409
申请日：2008-03-31
Applicant: Suzanne Lapi , Thomas J. Ruth , Dirk W. Becker , John M. D'Auria
Inventor： Suzanne Lapi , Thomas J. Ruth , Dirk W. Becker , John M. D'Auria
CPC classification number: C01G47/00 , A61K51/1282 , B01D59/44 , C01G39/00 , C01P2006/88
Abstract: A method of isolating 186Re according to example embodiments may include vaporizing a source compound containing 185Re and 186Re. The vaporized source compound may be ionized to form negatively-charged molecules containing 185Re and 186Re. The negatively-charged molecules may be separated to isolate the negatively-charged molecules containing 186Re. The isolated negatively-charged molecules containing 186Re may be collected with a positively-charged collector. Accordingly, the isolated 186Re may be used to produce therapeutic and/or diagnostic radiopharmaceuticals having higher specific activity.
Abstract translation: 根据实施例的分离186Re的方法可以包括蒸发含有185Re和186Re的源化合物。 蒸发的源化合物可以被电离以形成含有185Re和186Re的带负电荷的分子。 可以分离带负电荷的分子以分离含有186Re的带负电荷分子。 含有186Re的分离的带负电荷分子可以用带正电收集器收集。 因此，分离的186Re可用于产生具有较高比活性的治疗和/或诊断放射性药物。
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Patent Agency Ranking
公开(公告)号：US20110079108A1
公开(公告)日：2011-04-07
申请号：US12588030
申请日：2009-10-01
Applicant: Suzanne Lapi , Thomas J. Ruth , Dirk W. Becker , John M. D'Auria
Inventor： Suzanne Lapi , Thomas J. Ruth , Dirk W. Becker , John M. D'Auria
CPC classification number: C22B34/34 , B01J19/081 , C22B7/002 , G21G1/001 , G21G2001/0036 , Y02P10/212
Abstract: A method of isolating 99Mo produced using a (n,γ) reaction according to example embodiments may include vaporizing a source compound containing 98Mo and 99Mo. The vaporized source compound may be ionized to form ions containing 98Mo and 99Mo. The ions may be separated to isolate the ions containing 99Mo. The isolated ions containing 99Mo may be collected with a collector. Accordingly, the isolated 99Mo may have a relatively high specific radioactivity and, in turn, may be used to produce the diagnostic radioisotope, 99mTc, through radioactive decay.
Abstract translation: 根据实施例的使用（n，γ）反应分离的99Mo的分离方法可以包括蒸发含有98Mo和99Mo的源化合物。 蒸发的源化合物可以被离子化以形成含有98Mo和99Mo的离子。 可以分离离子以分离含有99Mo的离子。 含有99Mo的离子离子可以用收集器收集。 因此，分离的99Mo可以具有相对较高的比放射性，并且依次可以通过放射性衰变来产生99m Tc的诊断放射性同位素。
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公开(公告)号：US20080241025A1
公开(公告)日：2008-10-02
申请号：US12078409
申请日：2008-03-31
Applicant: Suzanne Lapi , Thomas J. Ruth , Dirk W. Becker
Inventor： Suzanne Lapi , Thomas J. Ruth , Dirk W. Becker
IPC: C01G47/00
CPC classification number: C01G47/00 , A61K51/1282 , B01D59/44 , C01G39/00 , C01P2006/88
Abstract: A method of isolating 186Re according to example embodiments may include vaporizing a source compound containing 185Re and 186Re. The vaporized source compound may be ionized to form negatively-charged molecules containing 185Re and 186Re. The negatively-charged molecules may be separated to isolate the negatively-charged molecules containing 186Re. The isolated negatively-charged molecules containing 186Re may be collected with a positively-charged collector. Accordingly, the isolated 186Re may be used to produce therapeutic and/or diagnostic radiopharmaceuticals having higher specific activity.
Abstract translation: 根据示例性实施方案的分离
Re的方法可以包括蒸发含有CH 2 Re和C 14 Re 12 Re的源化合物。 蒸发的源化合物可以被离子化以形成含有185 Re Re和Re Re 18 Re的带负电荷的分子。 可以分离带负电荷的分子以分离含有 Re Re的带负电荷分子。 可以用带正电收集器收集分离的含有<！ - SIPO- > Re的带负电荷分子。 因此，分离的186 Re可用于产生具有较高比活性的治疗和/或诊断性放射性药物。 -
公开(公告)号：US08211390B2
公开(公告)日：2012-07-03
申请号：US12659167
申请日：2010-02-26
Applicant: Suzanne Lapi , Thomas J. Ruth , Dirk W. Becker , John M. D'Auria
Inventor： Suzanne Lapi , Thomas J. Ruth , Dirk W. Becker , John M. D'Auria
CPC classification number: C01G47/00 , A61K51/1282 , B01D59/44 , C01G39/00 , C01P2006/88
Abstract: A method of isolating a radioisotope according to example embodiments may include vaporizing a source compound containing a first isotope and a second isotope of an element, wherein the second isotope may have at least one of therapeutic and diagnostic properties when used as a radiopharmaceutical. The vaporized source compound may be ionized to form charged particles of the first and second isotopes. The charged particles may be separated to isolate the particles of the second isotope. The isolated charged particles of the second isotope may be collected with an oppositely-charged collector. Accordingly, the isolated second isotope may be used to produce therapeutic and/or diagnostic radiopharmaceuticals having higher specific activity.
Abstract translation: 根据示例性实施方案的分离放射性同位素的方法可以包括蒸发含有元素的第一同位素和第二同位素的源化合物，其中当用作放射性药物时，第二同位素可以具有治疗和诊断性质中的至少一种。 蒸发的源化合物可以被电离以形成第一和第二同位素的带电粒子。 可以分离带电粒子以分离第二同位素的颗粒。 可以用带相反电荷的收集器收集分离的第二同位素带电粒子。 因此，分离的第二同位素可用于产生具有较高比活性的治疗和/或诊断性放射性药物。
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公开(公告)号：US20100160614A1
公开(公告)日：2010-06-24
申请号：US12659167
申请日：2010-02-26
Applicant: Suzanne Lapi , Thomas J. Ruth , Dirk W. Becker , John M. D'Auria
Inventor： Suzanne Lapi , Thomas J. Ruth , Dirk W. Becker , John M. D'Auria
CPC classification number: C01G47/00 , A61K51/1282 , B01D59/44 , C01G39/00 , C01P2006/88
Abstract: A method of isolating a radioisotope according to example embodiments may include vaporizing a source compound containing a first isotope and a second isotope of an element, wherein the second isotope may have at least one of therapeutic and diagnostic properties when used as a radiopharmaceutical. The vaporized source compound may be ionized to form charged particles of the first and second isotopes. The charged particles may be separated to isolate the particles of the second isotope. The isolated charged particles of the second isotope may be collected with an oppositely-charged collector. Accordingly, the isolated second isotope may be used to produce therapeutic and/or diagnostic radiopharmaceuticals having higher specific activity.
Abstract translation: 根据示例性实施方案的分离放射性同位素的方法可以包括蒸发含有元素的第一同位素和第二同位素的源化合物，其中当用作放射性药物时，第二同位素可以具有治疗和诊断性质中的至少一种。 蒸发的源化合物可以被电离以形成第一和第二同位素的带电粒子。 可以分离带电粒子以分离第二同位素的颗粒。 可以用带相反电荷的收集器收集分离的第二同位素带电粒子。 因此，分离的第二同位素可用于产生具有较高比活性的治疗和/或诊断性放射性药物。
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公开(公告)号：US20070040115A1
公开(公告)日：2007-02-22
申请号：US11499681
申请日：2006-08-07
Applicant: Julia Publicover , Suzanne Lapi , Thomas Ruth
Inventor： Julia Publicover , Suzanne Lapi , Thomas Ruth
IPC: H01J47/00
CPC classification number: H05H6/00 , G01T1/29 , H05H1/0006 , H05H7/00
Abstract: Disclosed are methods for determining the energy of a particle beam, for example a proton beam, by measuring the ratio of the radioactivities associated with two radioisotopes that are simultaneously produced within a plurality of target foils versus the calculated beam energy drop through each individual foil. This method relies on the disparate production of related radioisotopes in a single material as a function of the beam energy. A calibration curve may be established by irradiating target metal foils of known thickness and measuring the relative radioactivities of at least two target radioisotopes resulting from that irradiation. In particular, the method can be used to determine beam energies in the 10 to 18 MeV range by measuring the relative production of 63Zn and 65Zn in natural Cu foils.
Abstract translation: 公开了通过测量与在多个目标箔中同时产生的两个放射性同位素相关联的放射活性与通过每个单独箔的计算的束能量降的比例来确定粒子束（例如质子束）的能量的方法。 该方法依赖于单个材料中相关放射性同位素的不同生产作为束能的函数。 可以通过照射已知厚度的目标金属箔并测量由该照射产生的至少两种靶放射性同位素的相对放射活性来建立校准曲线。 特别地，该方法可用于通过测量天然Cu箔中的 Zn Zn和 Zn Zn的相对产量来确定10至18MeV范围内的光束能量。
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