公开(公告)号：US20250146897A1

公开(公告)日：2025-05-08

申请号：US18702584

申请日：2022-10-07

Applicant: NOK CORPORATION ,  TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Takayuki SAKURAI ,  Kentaro OSADA ,  Hikaru TADANO ,  Tomohiro KAWAI ,  Keishi NISHIO

IPC: G01M3/22

Abstract: A rubber product capable of easily and accurately detecting the presence or absence of leakage and a position of the leakage is provided. A rubber product includes a gas chromic material that changes a color thereof reversibly or changes an electric resistance value thereof, due to oxidation-reduction reaction. The rubber product is a sealing member (sealing product 10) for sealing a gap between two members, wherein the sealing member includes a gas chromic material that changes a color thereof reversibly or changes an electric resistance value thereof, due to oxidation-reduction reaction, and has a ring shape.

公开(公告)号：US12286348B2

公开(公告)日：2025-04-29

申请号：US17624939

申请日：2020-07-06

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Kazuo Watanabe

IPC: C01B23/00

Abstract: An embodiment of the present invention provides a noble gas hydride having the following formula 1: NgnHm. In formula 1, Ng represents a noble gas atom, n represents an integer from 1-8, and m represents an integer from 1-46.

公开(公告)号：US12066507B2

公开(公告)日：2024-08-20

申请号：US17781246

申请日：2020-11-26

Applicant: National Institute of Advanced Industrial Science and Technology ,  NATIONAL INSTITUTE FOR MATERIALS SCIENCE ,  Tokyo University of Science Foundation

Inventor： Yasumoto Tanaka ,  Hirotake Yamamori ,  Takashi Yanagisawa ,  Shunichi Arisawa ,  Taichiro Nishio

IPC: G01R33/035 ,  G06N10/00 ,  H10N60/12

CPC classification number: G01R33/0354 ,  G06N10/00 ,  H10N60/12

Abstract: Proposed is a phase shift introduction method, a structure, and a circuit device for eliminating or minimizing a risk associated with dissimilar materials, solving in principle a problem of mixing of a signal current and a control current that occurs due to DC connection of a phase shifter to a signal line, and stably and reliably providing a phase shift that is desired to be introduced without being adversely effected by noise generated by an ambient magnetic field, which is generated due to use of an external power supply. A structure according to the present invention includes a phase shifter 101 and a closed-loop circuit 103 that is directly used for computation or storage, and a quantum phase shift is generated in the closed-loop circuit 103 by using a fractional flux quantum captured by the phase shifter 101 that is DC-separated from the closed-loop circuit 103.

公开(公告)号：US20240262859A1

公开(公告)日：2024-08-08

申请号：US18566013

申请日：2022-06-02

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Takeshi Wada ,  Kazuki Sato ,  Yuhei Takahashi

IPC: C07H23/00 ,  C07H1/00

CPC classification number: C07H23/00 ,  C07H1/00

Abstract: A novel nucleic acid oligomer and a method for producing the same. The nucleic acid oligomer includes a nucleotide unit represented by general formula (1) and a nucleotide unit represented by general formula (2), and optionally includes a nucleotide unit represented by general formula (3). In general formulas (1), (2), and (3): R1 represents a hydrogen atom, a hydroxyl group, an alkoxy group, an alkenyloxy group, an acyloxy group, a trialkylsilyloxy group, an alkoxyalkoxy group, a haloalkoxyalkoxy group, or a halogenyl group, and R2 represents a hydrogen atom, or R1 and R2 bond together to form a five- or more-membered ring optionally having a substituent and optionally having a hetero atom; Bs represents a nucleobase selected from the group consisting of adenine, guanine, cytosine, 5-methylcytosine, thymine, and uracil, the nucleobase optionally having a nucleobase protecting group; and X+ represents a counter cation

公开(公告)号：US20240156796A1

公开(公告)日：2024-05-16

申请号：US18278246

申请日：2022-02-25

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION ,  NIPPON CHEMIPHAR CO., LTD.

Inventor： Akiyoshi SAITOH ,  Daisuke YAMADA ,  Eriko NAKATA

IPC: A61K31/444 ,  A61K31/439 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/513 ,  A61P25/22

CPC classification number: A61K31/444 ,  A61K31/439 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/513 ,  A61P25/22

Abstract: The present invention provides a pharmaceutical composition for the treatment or prevention of stress-related disorders, stress-induced anxiety disorders, or stress-related disorders or anxiety disorders associated with depression, the composition containing a selective δ-opioid receptor agonist as an active component, wherein the selective δ-opioid receptor agonist preferably also has a μ-opioid receptor antagonist action and a κ-opioid receptor antagonist action.

公开(公告)号：US20240140918A1

公开(公告)日：2024-05-02

申请号：US18263513

申请日：2022-01-28

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION ,  NATIONAL CANCER CENTER

Inventor： Isamu SHIINA ,  Motoyuki SHIMONAKA ,  Takatsugu MURATA ,  Yuuki OBATA ,  Toshirou NISHIDA ,  Koji OKAMOTO

IPC: C07D263/32 ,  C07D213/56 ,  C07D277/30

CPC classification number: C07D263/32 ,  C07D213/56 ,  C07D277/30

Abstract: A compound represented by formula (1) below, useful for treating cancer. In the formula, R1 and R3-R8 each independently represents a hydrogen atom or an alkyl group, R2 represents a hydrogen atom or a group represented by —ORa, R9 represents a group represented by —C(O)NRcRf, Ra, Re, and Rf each independently represents a hydrogen atom, an arylalkyl group that may have a substituent, or a heteroarylalkyl group. A production method that enables the compound to be produced with high efficiency, and a pharmaceutical composition containing the compound as an active ingredient

公开(公告)号：US20240110922A1

公开(公告)日：2024-04-04

申请号：US18241473

申请日：2023-09-01

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION ,  JEOL Ltd.

Inventor： Tatsuya Higashi ,  Masaki Takiwaki ,  Koji Takahashi ,  Seketsu Fukuzawa

IPC: G01N33/68

CPC classification number: G01N33/6848

Abstract: An estrogen derivatization method uses a quaternary cation-containing 5-fluoro-2,4-dinitrophenyl compound represented by Formula (1):






where in Formula (1), X is a quaternary cation. A mass spectrometry method includes derivatizing estrogen by the above estrogen derivatization method. A derivatization reagent derivatizing estrogen includes a quaternary cation-containing 5-fluoro-2,4-dinitrophenyl compound represented by Formula (1), where in Formula (1), X is a quaternary cation.

公开(公告)号：US11932666B2

公开(公告)日：2024-03-19

申请号：US17965125

申请日：2022-10-13

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Takeshi Wada ,  Tatsuya Saito ,  Yuka Ishii ,  Yohei Nukaga

IPC: C07H19/073 ,  C07F5/02 ,  C07F9/6558 ,  C07F9/6584 ,  C07H19/173 ,  C07H21/00 ,  C12N15/113

CPC classification number: C07H19/173 ,  C07F5/02 ,  C07F9/6558 ,  C07F9/6584 ,  C07H19/073 ,  C07H21/00 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/31 ,  C12N2310/321 ,  Y02P20/55

Abstract: Provided is a polymerizable compound represented by a Formula E-1 or Formula E-2 shown in the description. In Formula E-1 or Formula E-2, R1 represents an alkoxy group, —NRN2, a hydroxy group, an aryl group, or an alkyl group, wherein RN each independently represents a hydrogen atom or an alkyl group having 1 to 10 carbon atoms; n represents an integer from 1 to 5; R3 represents a hydrogen atom, an acetyl group, a phenoxyacetyl group, a pivaloyl group, a benzyl group, a 4-methoxybenzyl group, a benzoyl group, a triphenylmethyl group, a 4,4′-dimethoxytrityl (DMTr) group, a 4-methoxytrityl (MMTr) group, a 9-phenylxanthenyl group, a trimethylsilyl group, a cyanomethoxymethyl group, a 2-(cyanoethoxy)ethyl group, or a cyanoethoxymethyl group; and X represents a structure represented by any one of Formula B-1 to Formula B-5 shown in the description.

公开(公告)号：US11920045B2

公开(公告)日：2024-03-05

申请号：US16837153

申请日：2020-04-01

Applicant: RICOH COMPANY, LTD. ,  TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Soh Noguchi ,  Mitsunobu Morita ,  Takashi Okada ,  Tatsuki Yamaguchi ,  Koji Arimitsu

IPC: C09D11/10 ,  B33Y70/00 ,  C09D11/101 ,  C09D11/38 ,  B29C64/112 ,  B33Y10/00

CPC classification number: C09D11/101 ,  B33Y70/00 ,  C09D11/38 ,  B29C64/112 ,  B33Y10/00

Abstract: To provide an active-energy-ray-curable composition including a compound represented by General Formula (I) below:




where in the General Formula (I), R is hydrogen or a methyl group; A is a structure expressed by one selected from the group consisting of Structural Formulas (II) to (VII) below, each of which may have a substituent such as an alkyl group or an alkoxy group, or both; j and k in the Structural Formulas (VI) and (VII) are an integer of 0 or more; X denotes a substituent including a heteroatom; n is an integer of 0 or more, m is an integer of 1 or more, and n+m is 3 or more, or n is an integer of 0 and m is an integer of 2; and wavy lines in the Structural Formulas (II) to (VII) each independently denote a bond with X or a (meth)acryloyl group (H2C═CR—C(═O)—):

公开(公告)号：US11919932B2

公开(公告)日：2024-03-05

申请号：US18092737

申请日：2023-01-03

Applicant: The University of Tokyo ,  ONO PHARMACEUTICAL CO., LTD. ,  TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Kouji Matsushima ,  Satoshi Ueha ,  Shungo Deshimaru ,  Chang-Yu Chen ,  Shoji Yokochi ,  Yoshiro Ishiwata ,  Shiro Shibayama

IPC: C07K14/00 ,  A61P35/00 ,  C07K14/47 ,  A61K38/00

CPC classification number: C07K14/47 ,  A61P35/00 ,  A61K38/00

Abstract: Disclosed are a novel therapeutic means effective and practical against cancer, and a novel substance useful as such a therapeutic means. Provided are novel peptides derived from a partial region of HMGN1, HMGN2, HMGN4 or HMGN5, and anti-cancer agents and anti-cancer effect enhancers containing the peptide as an active ingredient. The peptide of the present invention has an anti-tumor effect even independently, and exerts a remarkably excellent anti-tumor effect particularly when used in combination with an immune checkpoint regulator, or an anti-CD4 antibody or antigen-binding fragment thereof.