公开(公告)号：US20130302268A1

公开(公告)日：2013-11-14

申请号：US13982492

申请日：2012-01-25

Applicant: Tim Bowden ,  Kristoffer Bergman ,  Thomas Strand ,  Lennart Soderberg

Inventor： Tim Bowden ,  Kristoffer Bergman ,  Thomas Strand ,  Lennart Soderberg

IPC: A61K47/48

CPC classification number: A61K47/58 ,  A61K9/0014 ,  A61K31/765 ,  A61K31/785 ,  A61K31/787 ,  A61K47/32 ,  A61K47/61 ,  A61L26/00

Abstract: A composition for treating or preventing inflammatory-related conditions includes as an active principle a carrier which exhibits a plurality of a scavenger structure capable of mitigating the activity of a mediator of inflammatory-related conditions. The scavenger structure includes a nucleophilic centre complying with the formula X1(—R″—)(—R′)mHnwhere: a) X1 is a single-bonded heteroatom selected amongst N, O and S and exhibits a free electron pair; b) m is 0 or 1 and n is 1 or 2; c) —R″— is a bivalent organic group providing attachment to the carrier via one of its free valences and to X1 at the other free valence; and d) R′— is a monovalent organic group attached to the X1 via its free valence. A method for treating or preventing inflammatory-related conditions in an individual suffering from such conditions includes: providing the composition; and contacting the mediator within or separate from the individual.

Abstract translation: 用于治疗或预防炎症相关病症的组合物包括作为活性成分的载体，其显示出能够减轻炎性相关病症介质活性的多种清道夫结构。 清除结构包括符合式X1（-R“ - ）（ - R'）mHn的亲核中心，其中：a）X 1是选自N，O和S中的单键合杂原子，并表现出自由电子对; b）m为0或1，n为1或2; c）-R“ - 是通过其自由价之一向载体附着至另一自由价的X1的二价有机基团; 和d）R'是通过其自由价与X1连接的一价有机基团。 用于治疗或预防患有这种病症的个体的炎症相关病症的方法包括：提供组合物; 并且在个体内或与个体分开时将介体接触。

公开(公告)号：US09585987B2

公开(公告)日：2017-03-07

申请号：US12920117

申请日：2009-02-13

Applicant: Kristoffer Bergman ,  Tim Bowden ,  Thomas Engstrand ,  Jons Hilborn ,  Dmitri Ossipov

Inventor： Kristoffer Bergman ,  Tim Bowden ,  Thomas Engstrand ,  Jons Hilborn ,  Dmitri Ossipov

IPC: A61K31/728 ,  A61L27/54 ,  A61L24/00 ,  A61L24/08 ,  A61L27/20 ,  A61L27/44 ,  A61L27/52 ,  C08B37/08 ,  C08J3/075 ,  C08L5/08 ,  A61K31/785 ,  A61K31/74

CPC classification number: A61L27/54 ,  A61K31/728 ,  A61K31/74 ,  A61K31/785 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/08 ,  A61L27/20 ,  A61L27/44 ,  A61L27/52 ,  A61L2300/602 ,  C08B37/0072 ,  C08J3/075 ,  C08J2305/08 ,  C08L5/08

Abstract: A composition, which upon activation, spontaneously forms a cross-linked hydrogel in aqueous liquid, includes: a) a formulation containing a hyluronan (HA-formulation) which includes a hyaluronan backbone (HA backbone) and a plurality of a reactive substituent group (reactive HA substituent) which i) is directly attached to the HA backbone, and ii) exhibits the reactive HA-group, and b) a formulation of a homo-multifunctional cross-linking reagent (CLR-formulation) exhibiting a plurality of a reactive group (reactive CLR-group). The two reactive groups are selected as a pair of counterparts that mutually and selectively react with each other to form a linkage structure. The hydrogel contains a cross-linking structure which a) is attached to the hyaluronan via two or more of the linkage structure and is defined by the reagent. The cross-linking structure exhibits a plurality of hydroxyl groups. The composition can be used in vivo or ex vivo as a support matrix.

Abstract translation: 一种组合物，其在活化后自发地在含水液体中形成交联的水凝胶，包括：a）含有乙醛醛酸（HA-制剂）的制剂，其包括透明质酸骨架（HA骨架）和多个反应性取代基 反应性HA取代基），其i）直接连接到HA骨架上，和ii）表现出反应性HA基团，和b）表现出多个反应性的多功能交联剂（CLR-制剂） 组（反应性CLR组）。 两个反应性基团被选择为彼此相互选择性反应以形成连接结构的一对对应物。 水凝胶含有交联结构，a）通过两个或多个连接结构连接到透明质酸上，并由试剂定义。 交联结构表现出多个羟基。 组合物可以在体内或离体使用作为支持基质。

公开(公告)号：US20110008444A1

公开(公告)日：2011-01-13

申请号：US12920117

申请日：2009-02-13

Applicant: Kristoffer Bergman ,  Tim Bowden ,  Thomas Engstrand ,  Jons Hilborn ,  Dmitri Ossipov

Inventor： Kristoffer Bergman ,  Tim Bowden ,  Thomas Engstrand ,  Jons Hilborn ,  Dmitri Ossipov

IPC: A61K9/00 ,  C07H5/06 ,  A61K47/36 ,  A61P43/00 ,  C08F216/06 ,  C08G69/00 ,  C08G65/00 ,  C08G63/91

CPC classification number: A61L27/54 ,  A61K31/728 ,  A61K31/74 ,  A61K31/785 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/08 ,  A61L27/20 ,  A61L27/44 ,  A61L27/52 ,  A61L2300/602 ,  C08B37/0072 ,  C08J3/075 ,  C08J2305/08 ,  C08L5/08

Abstract: A composition, which upon activation, spontaneously forms a cross-linked hydrogel in aqueous liquid, includes: a) a formulation containing a hyluronan (HA-formulation) which includes a hyaluronan backbone (HA backbone) and a plurality of a reactive substituent group (reactive HA substituent) which i) is directly attached to the HA backbone, and ii) exhibits the reactive HA-group, and b) a formulation of a homo-multifunctional cross-linking reagent (CLR-formulation) exhibiting a plurality of a reactive group (reactive CLR-group). The two reactive groups are selected as a pair of counterparts that mutually and selectively react with each other to form a linkage structure. The hydrogel contains a cross-linking structure which a) is attached to the hyaluronan via two or more of the linkage structure and is defined by the reagent. The cross-linking structure exhibits a plurality of hydroxyl groups. The composition can be used in vivo or ex vivo as a support matrix.

Abstract translation: 一种组合物，其在活化后自发地在含水液体中形成交联的水凝胶，包括：a）含有乙醛醛酸（HA-制剂）的制剂，其包括透明质酸骨架（HA骨架）和多个反应性取代基 反应性HA取代基），其i）直接连接到HA骨架上，和ii）表现出反应性HA基团，和b）表现出多个反应性的多功能交联剂（CLR-制剂） 组（反应性CLR组）。 两个反应性基团被选择为彼此相互选择性反应以形成连接结构的一对对应物。 水凝胶含有交联结构，a）通过两个或多个连接结构连接到透明质酸上，并由试剂定义。 交联结构表现出多个羟基。 组合物可以在体内或离体使用作为支持基质。

公开(公告)号：US20060147490A1

公开(公告)日：2006-07-06

申请号：US10526965

申请日：2003-09-05

Applicant: Tim Bowden ,  Fredrik Nederberg ,  Jon Hillborn

Inventor： Tim Bowden ,  Fredrik Nederberg ,  Jon Hillborn

IPC: C08L85/02 ,  A61F2/00

CPC classification number: C08G83/003 ,  A61K9/0024 ,  A61K9/1075 ,  A61K9/2853 ,  A61K9/5146 ,  C08G63/6852 ,  C08G63/6922 ,  C08G63/912 ,  C09D201/005

Abstract: The present invention provides a biodegradable, biocompatible polymer that is capable of forming particles (micelles), vesicles, surfaces and membranes, and other structures in which a biologically active agent, e.g. a drug, can be incorporated in such a way that its release to the host can be controlled to a high degree of accuracy, or in where surfaces of the formed polymers can be used to increase the hemeo compatibility of biomaterials. The present invention provides polymer compounds comprising at least one biodegradable polyester having a terminal functional group based on hydrophilic moieties from a phospholipid.

Abstract translation: 本发明提供了一种可生物降解的生物相容性聚合物，其能够形成颗粒（胶束），囊泡，表面和膜以及其它结构，其中生物活性剂例如 药物可以以能够高度准确地控制其释放到宿主的方式，或者可以使用形成的聚合物的表面来增加生物材料的血液相容性的方式来引入。 本发明提供包含至少一种具有基于磷脂亲水部分的末端官能团的可生物降解聚酯的聚合物化合物。

公开(公告)号：US09302013B2

公开(公告)日：2016-04-05

申请号：US13982492

申请日：2012-01-25

Applicant: Tim Bowden ,  Kristoffer Bergman ,  Thomas Engstrand ,  Lennart Soderberg

Inventor： Tim Bowden ,  Kristoffer Bergman ,  Thomas Engstrand ,  Lennart Soderberg

IPC: A61K47/48 ,  A61K31/765 ,  A61K31/785

CPC classification number: A61K47/58 ,  A61K9/0014 ,  A61K31/765 ,  A61K31/785 ,  A61K31/787 ,  A61K47/32 ,  A61K47/61 ,  A61L26/00

Abstract: A composition for treating or preventing inflammatory-related conditions includes as an active principle a carrier which exhibits a plurality of a scavenger structure capable of mitigating the activity of a mediator of inflammatory-related conditions. The scavenger structure includes a nucleophilic center complying with the formula X1(—R″—)(—R′)mHn where: a) X1 is a single-bonded heteroatom selected amongst N, O and S and exhibits a free electron pair; b) m is 0 or 1 and n is 1 or 2; c) —R″— is a bivalent organic group providing attachment to the carrier via one of its free valences and to X1 at the other free valence; and d) R′— is a monovalent organic group attached to the X1 via its free valence. A method for treating or preventing inflammatory-related conditions in an individual suffering from such conditions includes: providing the composition; and contacting the mediator within or separate from the individual.

Abstract translation: 用于治疗或预防炎症相关病症的组合物包括作为活性成分的载体，其显示出能够减轻炎性相关病症介质活性的多种清道夫结构。 清除结构包括符合式X1（-R“ - ）（ - R'）mHn的亲核中心，其中：a）X1是选自N，O和S中的单键合杂原子，并表现出自由电子对; b）m为0或1，n为1或2; c）-R“ - 是一种二价有机基团，其通过其自由价中的一种与另一种游离价的X 1连接至载体; 和d）R'是通过其自由价与X1连接的一价有机基团。 用于治疗或预防患有这种病症的个体的炎症相关病症的方法包括：提供组合物; 并且在个体内或与个体分开时将介体接触。