公开(公告)号：US20250166201A1

公开(公告)日：2025-05-22

申请号：US19028076

申请日：2025-01-17

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph DACOSTA

IPC: G06T7/00 ,  A61B5/00 ,  G01N21/64

Abstract: A system for determining a bacterial load of a target is provided. The system includes an adaptor for configuring a mobile communication device for tissue imaging and a mobile communication device. The adaptor includes a housing configured to be removably coupled to a mobile communication device and, an excitation light source for fluorescent imaging. The excitation light source is configured to emit light in one of ultraviolet, visible, near-infrared, and infrared ranges.

公开(公告)号：US20250160649A1

公开(公告)日：2025-05-22

申请号：US19025446

申请日：2025-01-16

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph S. DaCosta ,  Brian C. Wilson ,  Kai Zhang

IPC: A61B5/00 ,  A61B5/01 ,  A61B10/00 ,  G01N21/64

Abstract: A device for fluorescence-based imaging and monitoring of a target is provided. The device includes a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce, and a light detector for detecting the fluorescence.

公开(公告)号：US20250152010A1

公开(公告)日：2025-05-15

申请号：US19025440

申请日：2025-01-16

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph S. DaCosta ,  Brian C. Wilson ,  Kai Zhang

IPC: A61B5/00 ,  A61B5/01 ,  A61B10/00 ,  G01N21/64

Abstract: A device for fluorescence-based imaging and monitoring of a target is provided. The device includes a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce, and a light detector for detecting the fluorescence.

公开(公告)号：US20250123285A1

公开(公告)日：2025-04-17

申请号：US18925936

申请日：2024-10-24

Applicant: The Governing Council of the University of Toronto ,  University Health Network

Inventor： Mark Nitz ,  Landon J. Edgar ,  Bradly G. Wouters ,  David Hedley ,  Lisa M. Willis ,  Matthew A. Lumba ,  Hanuel Park ,  Ravi N. Vellanki

IPC: G01N33/58 ,  C07D345/00 ,  C07D421/06 ,  C07H15/04 ,  G01N33/569

Abstract: A compound of formula (I): as described herein and methods and uses thereof as for mass tagging a biosensor or biologically active material.

公开(公告)号：US12251191B2

公开(公告)日：2025-03-18

申请号：US17856487

申请日：2022-07-01

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph Sebastian Dacosta ,  Brian C. Wilson ,  Kai Zhang

IPC: A61B5/00 ,  A61B5/01 ,  A61B10/00 ,  G01N21/64

Abstract: A system for outputting a representation of a wound in tissue comprises a housing configured to removably receive at least a portion of a wireless communication device. At least one light source coupled to the housing is configured to emit excitation light to illuminate a target which includes at least a portion of the wound. A power supply contained in the housing is configured to provide power to the light source. A non-transitory computer-readable medium stores a program executable to cause the performance of operations comprising detecting signals responsive to illumination of the target, outputting the representation of the target based thereon, storing data relative to one or more target surface parameter based on the detected signals, and displaying the representation. The signals correspond to at least one of endogenous or exogeneous fluorescence, absorbance, and reflectance from at least one biological component in and/or on the target.

公开(公告)号：US12227737B2

公开(公告)日：2025-02-18

申请号：US18061273

申请日：2022-12-02

Applicant: University Health Network ,  Sinai Health System

Inventor： Daniel Diniz De Carvalho ,  Shu Yi Shen ,  Rajat Singhania ,  Scott Victor Bratman ,  Ankur Ravinarayana Chakravarthy

IPC: C12N15/10 ,  C12Q1/6804 ,  C12Q1/6806 ,  C12Q1/6886 ,  C40B30/04 ,  G01N33/53

Abstract: There is described herein, a method of capturing cell-free methylated DNA from a sample having less than 100 mg of cell-free DNA, comprising the steps of: subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA; adding a first amount of filler DNA to the sample, wherein at least a portion of the filler DNA is methylated; denaturing the sample; and capturing cell-free methylated DNA using a binder selective for methylated polynucleotides.

公开(公告)号：US20250032606A1

公开(公告)日：2025-01-30

申请号：US18709405

申请日：2022-11-14

Applicant: David S. CAMPO ,  Richard URBANOWICZ ,  Mounir ABOUHAIDAR ,  UNIVERSITY HEALTH NETWORK ,  THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO ,  UNIVERSITY OF LIVERPOOL ,  CENTERS FOR DISEASE CONTROL AND PREVENTION ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC

Inventor： David S. CAMPO ,  Richard A. URBANOWICZ ,  Mounir G. ABOUHAIDAR ,  Alexander I. MOSA ,  Jordan J. FELD

IPC: A61K39/29 ,  A61K39/00 ,  A61K39/385 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  G16B15/30 ,  G16B40/30

Abstract: There is described herein polyvalent HCV vaccines, preferably comprising SEQ ID Nos. 1-5. There is also described herein methods of designing polyvalent vaccines.

公开(公告)号：US20250006375A1

公开(公告)日：2025-01-02

申请号：US18820166

申请日：2024-08-29

Applicant: University Health Network

Inventor： Scott Victor BRATMAN ,  Justin Matthew BURGENER ,  Daniel DINIZ DE CARVALHO

IPC: G16H50/20 ,  G01N33/53 ,  G16H50/30 ,  G16H50/70

Abstract: This is described herein, a method of capturing cell-free methylated DNA from a sample having less than 100 mg of cell-free DNA, comprising the steps of: subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA; adding a first amount of filler DNA to the sample, wherein at least a portion of the filler DNA is methylated; denaturing the sample; and capturing cell-free methylated DNA using a binder selective for methylated polynucleotides.

公开(公告)号：US20240366090A1

公开(公告)日：2024-11-07

申请号：US18662750

申请日：2024-05-13

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ralph S. DaCosta ,  Brian C. Wilson ,  Kai Zhang

IPC: A61B5/00 ,  A61B5/01 ,  A61B10/00 ,  G01N21/64

Abstract: A portable imaging system for visualizing bacteria in a wound in real time includes an excitation light source configured to emit violet and/or blue excitation light to illuminate a wound and cause at least one biomarker associated with the wound to fluoresce and a camera configured to detect fluorescence emitted by the at least one biomarker associated with the wound in response to illumination of the wound with the excitation light. A portable frame is configured to support the camera and the excitation light source for hands-free operation and to position the camera and the excitation light source relative to the wound. The system also includes a power source for the excitation light source.

公开(公告)号：US20240352535A1

公开(公告)日：2024-10-24

申请号：US18684427

申请日：2022-08-17

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  University Health Network

Inventor： Paul C. BOUTROS ,  Michael FRASER

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: Disclosed herein are methods and compositions for treatment, prognosis, and diagnosis of cancer, including prostate cancer. Aspects of the disclosure are directed to methods for a subject having prostate cancer determined to have ZNRF3 genomic loss, reduced ZNRF3 expression, and/or increased ZNRF3 methylation. Also disclosed are methods for analysis of tumor DNA for ZNRF3 copy number status, expression, and/or methylation, as well as compositions and kits useful for such analysis.