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公开(公告)号：US20250161495A1
公开(公告)日：2025-05-22
申请号：US18834925
申请日：2023-02-01
Applicant: University of Rochester
Inventor： Steven A. Goldman , Abdellatif Benraiss
IPC: A61K48/00 , A61K35/30 , A61K38/17 , C12N5/0793 , C12N9/22 , C12N15/11 , C12N15/113 , C12N15/86
Abstract: The present disclosure is directed to a method of generating a population of neurons. This method involves providing a population of human glial progenitor cells: providing a recombinant genetic construct comprising (i) a promoter and/or enhancer for a gene which is selectively or specifically expressed by human glial progenitor cells, and (ii) a nucleic acid sequence encoding one or more neuronal reprogramming factors for producing neurons from glial progenitor cells, where the nucleic acid sequence is operably linked to the 3′ end of said promoter and/or enhancer to achieve expression of the one or more neuronal reprogramming factors; transfecting cells of the glial progenitor cell population with the recombinant genetic construct; and culturing the population after said transfecting under conditions suitable for neuron production from the transfected glial progenitor cells of the population. Also disclosed are methods of inducing the production of neurons, as well as recombinant genetic constructs.
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公开(公告)号：US20250134919A1
公开(公告)日：2025-05-01
申请号：US18835570
申请日：2023-02-06
Applicant: University of Rochester
Inventor： John D. Lueck , Joseph J. Porter
IPC: A61K31/7105 , A61K48/00 , A61P27/02 , C12N15/113 , C12N15/67
Abstract: The present disclosure relates to nucleic acids, compositions, and methods for treating a disease or disorder associated with premature termination codon. Certain aspects of the disclosure relate to polynucleotides, vectors, and host cells, and uses thereof.
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公开(公告)号：US20250105828A1
公开(公告)日：2025-03-27
申请号：US18728224
申请日：2023-01-12
Applicant: University of Rochester
Inventor： Zeljko Ignjatovic , Yiqiao Zhang
Abstract: A computation node comprises an input, an output, a bistable node, comprising an input and an output, the output configured to have at least two equilibrium output voltages, a first buffer circuit, having an input and an output, the buffer input connected to the bistable node and the buffer output connected to the computation node, the buffer circuit configured to provide a first output voltage when a voltage at the buffer input is below a threshold, and a second output voltage when the voltage at the buffer input is above the threshold, and a current conveyor node having an input connected to the computation node and an output connected to the bistable node, the current conveyor configured to hold its input at a constant voltage and mirror current received at the input into the input of the bistable node. A network of resistively-coupled computation nodes is also described.
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公开(公告)号：US20250097642A1
公开(公告)日：2025-03-20
申请号：US18810815
申请日：2024-08-21
Applicant: UNIVERSITY OF ROCHESTER
Abstract: Systems and methods of driving plate loudspeakers with different parameters based on frequency region in a way similar to typical cone driver crossover networks are described. These systems and methods may be implemented using arrays of independently controlled drivers which allow a designer to emphasize or de-emphasize certain modes in certain frequency bands. Tuning the characteristics of the plate's motion can also affect the acoustical properties in a larger space rather than just at a single location. The systems and methods described herein can grant a designer a degree of control over the characteristics and performance of the plate.
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公开(公告)号：US20250095532A1
公开(公告)日：2025-03-20
申请号：US18884530
申请日：2024-09-13
Applicant: University of Rochester , New York University
Inventor： Qi Sun , Yuhao Zhu , Budmonde Duinkharjav , Kenneth Chen , Abhishek Tyagi , Jiayi He
Abstract: Saving power in an extended-reality device can include rendering a video stream on a display, tracking an eye of a user observing the display, ascertaining a gaze direction of the eye based on tracking the eye, calculating a foveal region of the display based on ascertaining the gaze direction in relation to the display, and modulating color hues of the video stream for pixels of the display outside the foveal region, to reduce a power consumption of the display. Modulating color hues is based on human color discrimination and display power consumption correlated to pixel color.
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Patent Agency Ranking
公开(公告)号：US20250049957A1
公开(公告)日：2025-02-13
申请号：US18722690
申请日：2022-12-22
Applicant: University of Rochester , University of Copenhagen , Karolinska Institutet
Inventor： Maiken Nedergaard , Barbara K. Mathiesen , Christopher R. Cederroth , Barbara Canlon
IPC: A61K48/00 , A61P27/16 , C07K14/705 , C12N15/86
Abstract: This disclosure relates to delivery of various agents to the inner ear of a subject.
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公开(公告)号：US20250025049A1
公开(公告)日：2025-01-23
申请号：US18765983
申请日：2024-07-08
Applicant: UNIVERSITY OF ROCHESTER
Inventor： Kevin PARKER
Abstract: A reverberant shear wave field in an object such as a patient's body or organ causes deformations in one or more selected directions measured with an imaging modality such as ultrasound or MR equipment or other imaging equipment, to estimate displacements in one or more selected directions over time increments and then viscoelastic properties such as stiffness or other parameters of the ROI.
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公开(公告)号：US20250019702A1
公开(公告)日：2025-01-16
申请号：US18708790
申请日：2022-11-07
Applicant: University of Rochester
Inventor： Peng YAO , Omar HEDAYA
IPC: C12N15/113 , A61P9/00
Abstract: The present application provides compositions and methods for treating cardiac hypertrophy. In one embodiment, the composition comprises an antisense oligonucleotide 10-50 nucleotides in length, wherein the antisense oligonucleotide is capable of forming a double-stranded structure with a target region downstream of a start codon of an upstream open reading frame (uORF) resided within an mRNA of GATA4, wherein the target region spans a double-stranded stem of a stem-loop structure downstream of the GATA4 uORF start codon
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公开(公告)号：US20240390399A1
公开(公告)日：2024-11-28
申请号：US18778820
申请日：2024-07-19
Applicant: Indiana University Research and Technology Corporation , University of Rochester , The U.S.A. of America As Represented by the Department of Veterans Affairs Office of General Council
Inventor： Teresita M. Bellido , G. David Roodman , Jesus Delgado-Calle , Robert K. Boeckman , Frank H. Ebetino
IPC: A61K31/664 , A61K38/29 , A61K45/06 , A61P35/00 , C07F9/38
Abstract: Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reducing resistence to the treatment, prevention, and diagnosis of diseases/symptoms induced by multiple myeloma. Embodiments include methods of treating a bone related disease, comprising the steps of: administering to a subject at least one therapeutically effective dose of a compound disclosed herein.
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公开(公告)号：US20240346735A1
公开(公告)日：2024-10-17
申请号：US18633750
申请日：2024-04-12
Applicant: University of Rochester
Inventor： Luchuan Song , Chenliang Xu
CPC classification number: G06T13/40 , G06T3/18 , G06T7/20 , G06T7/70 , G06T17/20 , G06V10/44 , G06V40/174 , H04N21/816
Abstract: Features described herein pertain to generative machine learning, and more particularly, to machine learning techniques for generating virtual characters. A video that depicts a first subject and includes an audio component that corresponds to speech spoken by the first subject and an image that depicts a second subject are provided to and used by one or more machine learning models to generate a video that depicts the second subject. The second subject can blink and exhibit emotional characteristic and reactions that are responsive to the speech spoken by the first subject and/or a characteristic of the first subject such as a facial expression and/or head pose motion. The generated video can be displayed and/or stored where it can be later retrieved.
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