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    Protein-free semen cryopreservation
    3.
    发明授权
    Protein-free semen cryopreservation 有权

    公开(公告)号：US11819019B2

    公开(公告)日：2023-11-21

    申请号：US16768807

    申请日：2018-12-03

    Applicant: University of Saskatchewan

    Inventor： Francois Eudes ,  Jaswant Singh ,  Kosala Rajapaksha ,  Muhammad Anzar ,  Gregg P. Adams

    IPC: A01N1/02 ,  C12N5/076

    CPC classification number: A01N1/0221 ,  A01N1/0278 ,  A01N1/0284 ,  C12N5/061

    Abstract: This disclosure provides a preserving composition comprising a cholesterol: carrier complex, optionally a cholesterol:cyclodextrin complex (CC complex) and/or a cell permeable antioxidant peptide and a biological buffer and optionally a cryprotectant, wherein the preserving composition is optionally substantially free of animal phospholipid, animal protein and/or animal lipoprotein. The disclosure also provides methods for the use of the preserving composition in cryopreservation of semen or sperm cells. Also provided is a kit comprising the preserving composition having a CC complex, a biological buffer, a cryoprotectant, a carbohydrate, a pH stabilizer, an antibiotic or antibiotic cocktail and/or a cell permeable anti-oxidant peptide.

    NEURONAL AGONISTS AND ISOTONIC OR HYPERTONIC SALINE FOR TREATING RESPIRATORY DISEASES
    9.
    发明申请
    NEURONAL AGONISTS AND ISOTONIC OR HYPERTONIC SALINE FOR TREATING RESPIRATORY DISEASES 有权

    公开(公告)号：US20210228511A1

    公开(公告)日：2021-07-29

    申请号：US17156167

    申请日：2021-01-22

    Applicant: University of Saskatchewan

    Inventor： Juan P. Ianowski ,  Julian S. Tam ,  Xiaojie Luan ,  Veronica A. Campanucci

    IPC: A61K31/165 ,  A61K33/14 ,  A61K9/00 ,  A61K31/05

    Abstract: The present application relates to a method of increasing the volume of an airway surface liquid (ASL) layer and/or increasing mucociliary clearance in a subject. For example, the application relates the use of one or more neuronal agonists such as menthol and/or capsaicin, in combination with hypertonic saline (HTS) or isotonic saline (ITS) for increasing the volume of airway surface liquid (ASL) and/or increasing mucociliary clearance or for treatment of a disease, disorder or condition treatable by increasing the volume of an ASL layer and/or increasing mucociliary clearance. For example, the disease, disorder or condition is cystic fibrosis or a non-cystic fibrosis respiratory disease, disorder or condition such as non-cystic fibrosis bronchiectasis.

    METHOD AND SYSTEM OF LASER-DRIVEN INTENSE X-RAY PHOTONS IMAGING
    10.
    发明申请
    METHOD AND SYSTEM OF LASER-DRIVEN INTENSE X-RAY PHOTONS IMAGING 有权

    公开(公告)号：US20210219410A1

    公开(公告)日：2021-07-15

    申请号：US17250302

    申请日：2019-07-04

    Applicant: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITY OF SASKATCHEWAN

    Inventor： Sylvain FOURMAUX ,  Jean-Claude KIEFFER ,  Emil HALLIN

    IPC: H05G2/00 ,  G01N23/041 ,  G01N33/00

    Abstract: A X-ray source, comprising a laser, of a pulse duration of at most 40 fs, instantaneous power of at least about 80TW, a pulse repetition rate of at least 1 Hz; an optical compressor spectrally shaping the laser beam; focusing optics in the range between f#10 and f#15; and a gas target of electron density after ionization by the laser beam in a range between 1018 cm3 and 1019 cm−3; wherein the focusing optics focuses the laser beam in the gas target, and interaction of the focused laser beam with the gas target generates an X-ray beam, with a focused laser amplitude a0, given by a0=0.855 [IL (1018W/cm2)λL,2 (μm)]1/2, where IL is the on-target laser intensity and λL is the laser wavelength, of at least 2 and a P/Pc ratio value of at least 20, with P being the beam power and Pc a critical power given by Pc=17 (nc/n) GW where n is the electron density and nc is a critical electron density at which the plasma acts as a mirror reflecting the laser beam.

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