公开(公告)号：US20230158209A1

公开(公告)日：2023-05-25

申请号：US18057125

申请日：2022-11-18

Applicant: University of Southern California ,  Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California

Inventor： Yang Chai ,  Mengfei Yu

IPC: A61L27/38 ,  A61L27/26 ,  A61L27/22 ,  A61L27/36 ,  A61L27/24 ,  A61L27/58 ,  A61L27/54

CPC classification number: A61L27/3834 ,  A61L27/24 ,  A61L27/26 ,  A61L27/54 ,  A61L27/58 ,  A61L27/222 ,  A61L27/227 ,  A61L27/3633 ,  A61L2300/412

Abstract: Disclosed herein are compositions of biodegradable scaffolds combined with mesenchymal stem cells and methods of use thereof for the regeneration of cranial sutures and treatment of craniosynostosis, which can help reverse increased intracranial pressure and skull and neurocognitive abnormalities.

公开(公告)号：US10646518B2

公开(公告)日：2020-05-12

申请号：US15500726

申请日：2015-08-07

Applicant: Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California ,  University of Southern California

Inventor： Songtao Shi ,  Dawei Liu ,  Cunye Qu

IPC: A61K35/28 ,  C12N5/0775 ,  A61K35/12 ,  A61K9/00

Abstract: This disclosure relates to apoptotic bodies. The disclosure particularly relates to a composition comprising the apoptotic bodies. The disclosure further relates to preparation of apoptotic bodies from stem cells. The disclosure also relates to medical treatments comprising the use of the composition comprising the apoptotic bodies. The apoptotic bodies may comprise apoptotic stem cells. The apoptosis of a cell may be induced by a starvation method, an ultra-violet irradiation method, a thermal stress method, a staurosporine method, or a combination thereof.

公开(公告)号：US12295831B2

公开(公告)日：2025-05-13

申请号：US18508702

申请日：2023-11-14

Applicant: California Institute of Technology ,  University of Southern California

Inventor： Yu-Chong Tai ,  Mark S. Humayun

IPC: A61F2/16

Abstract: An accommodating intraocular lens (IOL) is formed from an anterior or posterior half molded as a chambered, polymer sack with a mouth opening smaller than its largest width that is mated to another half molded as a pliable bowl having a rim larger than the rest of the half. The resulting shell has a seam that is parallel to and does not cross or touch the equator such that the IOL is asymmetric between its front and back. A circular depression around the optical axis can be made in the anterior and/or posterior half such that a surrounding capsular bag seals against the rim of the depression, and an interior of the depression(s) does not touch the capsular bag.

公开(公告)号：US20250136942A1

公开(公告)日：2025-05-01

申请号：US18932104

申请日：2024-10-30

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Zhipeng LU ,  Minjie ZHANG ,  Kongpan LI ,  Jianhui BAI

IPC: C12N5/077 ,  A61K35/34 ,  C12N9/22 ,  C12N15/113

Abstract: The disclosure provides methods of promoting stem cell differentiation into mesoderm and endoderm cell lineages comprising, for example, contacting a stem cell with an agent that reduces or eliminates gene activity of one or more endogenous small nuclear ribonucleic acid (snoRNA) molecules, wherein the snoRNA molecules comprise SNORD97 and/or SNORD133. Also provided are isolated cardiomyocytes and compositions of the same, wherein the cardiomyocytes are produced using a method described herein.

公开(公告)号：US20250136725A1

公开(公告)日：2025-05-01

申请号：US18926973

申请日：2024-10-25

Applicant: University of Southern California

Inventor： Megan FIESER ,  Zachary WOOD

IPC: C08F8/26 ,  C08F299/00

Abstract: A method for dechlorinating a starting chlorinated polymer includes a step of contacting the starting chlorinated polymer with a solution that includes a cation initiator, an organosilane, and chlorinated solvent at a predetermined temperature for a sufficient time to at least partially dechlorinate the starting chlorinated polymer. Complete or partial dechlorination can be achieved depending on the reaction conditions. A block copolymer formed by the method is also provided.

公开(公告)号：US20250098723A1

公开(公告)日：2025-03-27

申请号：US18960999

申请日：2024-11-26

Applicant: University of Southern California

Inventor： Valter D. LONGO ,  Min WEI ,  Priya RANGAN

IPC: A23L33/20 ,  A23L33/00 ,  A61K9/00 ,  A61K47/26 ,  A61K47/42 ,  A61K47/44

Abstract: A method of treating Alzheimer's associated pathology includes a step of identifying subject having a pathology that is associated with Alzheimer's disease. A fasting mimicking diet (FMD) is then administered to the subject for a first time period. Methods for treating amyloid plaque formation and/or elevated levels of tau protein as well as neuroinflammation are also provided.

公开(公告)号：US20250092143A1

公开(公告)日：2025-03-20

申请号：US18580889

申请日：2022-07-22

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Yong ZHANG ,  Qinqin CHENG

IPC: C07K16/28 ,  A61K9/50 ,  A61K35/00 ,  A61K38/00 ,  C07K14/705 ,  C07K14/71

Abstract: The disclosure provides for an engineered extracelluar vesicle and methods of using the same where the engineered extracellular vesicle comprises a first fusion protein having the formula A-B-C, wherein A is a first antibody moiety, B is a second antibody moiety, and C is a first exosomal protein transmembrane domain; and a second fusion protein comprising the formula D-E-F, wherein D is a first protein binding moiety, E is a second exosomal membrane protein transmembrane domain, and F is a second protein binding moiety; wherein both the first fusion protein and the second fusion protein are displayed on a surface of the engineered extracellular vesicle, and the first antibody moiety and the second antibody moiety separately bind to a an immune cell marker protein and a cancer cell surface-marker protein, and the first binding protein moiety and the second protein binding moiety separately bind to a second immune cell marker protein and a second cancer cell surface-marker protein.

公开(公告)号：US20250091000A1

公开(公告)日：2025-03-20

申请号：US18959398

申请日：2024-11-25

Applicant: University of Southern California ,  Tai Chong Cheang Steamship Co. (H.K.) Limited

Inventor： Stephen B. CRONIN ,  Alec NYSTROM ,  Sriram SUBRAMANIAN ,  Vyaas GURURAJAN ,  Haotian SHI ,  Martin A. GUNDERSEN ,  William SCHROEDER ,  Sisi YANG ,  Christi SCHROEDER ,  Fokion EGOLFOPOULOS ,  Tom HUISKAMP

IPC: B01D53/32 ,  B01D53/50 ,  B01D53/56 ,  B01D53/60

Abstract: This invention relates to methods and systems for reducing the concentration of SOx and/or NOx in gas streams.

公开(公告)号：US20250090607A1

公开(公告)日：2025-03-20

申请号：US18962908

申请日：2024-11-27

Applicant: University of Southern California

Inventor： Valter D. LONGO ,  Min WEI ,  Priya RANGAN

IPC: A61K35/747 ,  A23L3/44 ,  A23L33/135 ,  A61K9/16 ,  A61K9/48 ,  A61K35/00 ,  A61K35/745 ,  A61K45/06

Abstract: A method for treating autoimmune and/or inflammatory disease includes a step of identifying a subject exhibiting symptoms of autoimmune and/or inflammatory disease administering a fasting mimicking diet. The fasting mimicking diet provides the subject with at most 50% to 75% of the subject's normal caloric intake. A probiotic composition for gastrointestinal autoimmune and/or inflammatory disease Bacteroides acidifaciens, Bifidobacterium choerinum, and combinations thereof is also provided.

公开(公告)号：US12240821B2

公开(公告)日：2025-03-04

申请号：US17274736

申请日：2019-07-12

Applicant: University of Southern California

Inventor： Chao Zhang ,  Feng Ni ,  Arunika Ekanayake ,  Biancha Espinosa

IPC: C07D239/94 ,  A61K31/167 ,  A61K31/517 ,  A61K45/06 ,  A61P35/00 ,  C07C235/56 ,  C07C237/42

Abstract: The invention provides a series of GMPS enzyme inhibitors. The invention includes potent GMPS inhibitors that specifically and covalently bind to GMPS, exhibit broad anti-cancer activity, block the infection efficiency of viruses, and have the potentials to suppress undesired immune responses. These novel inhibitors of GMPS, and their derivatives, have tremendous potentials to be used as therapeutic agents for the treatment of cancers, viral infection and immune disorders.