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公开(公告)号：US20250152618A1
公开(公告)日：2025-05-15
申请号：US18838844
申请日：2023-02-13
Inventor： Alfonso FERNÁNDEZ-MAYORALAS ÁLVAREZ , Julia REVUELTA CRESPO , Eduardo GARCÍA-JUNCEDA REDONDO , Agatha BASTIDA CODINA , Ron GELLER , Clara FRANCÉS GÓMEZ , Victor LATORRE ROSELLÓ , Miguel Ángel MARTÍN ACEBES , Juan Carlos SAIZ CALAHORRA , Alfonso GUTIÉRREZ ADÁN
IPC: A61K31/737 , A61P31/14 , C08B37/08
Abstract: The invention relates to sulfated chitosan derivatives of formula (I), wherein the meanings for the various substituents are as disclosed in the description, for their use in the treatment and/or prevention of a viral infection, particularly wherein the viral infection is caused by SARS-CoV-2 such as COVID-19 or RSV.
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公开(公告)号：US11179348B2
公开(公告)日：2021-11-23
申请号：US15746311
申请日：2016-06-09
Applicant: FUNDACIÓN UNIVERSIDAD CATÓLICA DE VALENCIA SAN VICENTE MÁRTIR , UNIVERSITAT DE VALÈNCIA-ESTUDI GENERAL , FUNDACIÓ INVESTIGACIÓ HOSPITAL GENERAL UNIVERSITARI DE VALÈNCIA PER A LA INVESTIGACIÓ BIOMÈDICA I CIÈNCIES DE LA SALUT , IDCQ HOSPITALES Y SANIDAD, S.L.U.
Inventor： José María Estrela Arigüel , María Benlloch García , María Elena Plá Obrador , Lilian Soraya Vallés Martín , María Lucía Rodríguez Romero , Joan Antoni Sirerol Talens , Javier Luis Alcácer García , José Alfredo Pellicer Artés , Rosario Salvador Palmer , Guillermo María Sáez Tormo , Concepción Cerdá Micó
IPC: A61K31/09 , A61P35/00 , A61K31/225 , A61K31/277 , A61K31/42 , A61K31/4412 , A61K31/551 , A61K31/635
Abstract: The present invention relates to a combination comprising pterostilbeneor pterostilbene phosphate or a pharmaceutically acceptable salt thereof, a glutathione depleting agent and a cancer chemotherapeutic agent. The invention also relates to the medical use of this combination, in particular for the treatment and/or prevention of cancer.
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公开(公告)号：US20210261577A1
公开(公告)日：2021-08-26
申请号：US17057808
申请日：2019-05-23
Applicant: UNIVERSITAT DE VALÈNCIA , UNIVERSIDAD DE GRANADA
Inventor： Carlos MARTI GASTALDO , Javier CASTELLS GIL , Natalia MUÑOZ PADIAL
Abstract: The present invention relates to a new family of titanium heterometallic structured metal-organic materials (MOFs) having, among other characteristics, high porosity, stability in an aqueous medium and photocatalytic activity under visible light and UV radiation. The new family of materials has a structural unit that combines tetravalent titanium with multiple combinations of divalent metals with a homogeneous distribution at atomic level in the MOF structure.
The invention also relates to methods for obtaining them with high yields, in addition to their uses in the generation of solar fuels, photoactivated degradation, photoreduction of CO2, heterogeneous catalysis, as a component or part of an electronic component and/or as a porous or photoactive coating for controlling pollutants, inter alia.-
公开(公告)号：US20200264190A1
公开(公告)日：2020-08-20
申请号：US16346978
申请日：2017-11-06
Applicant: Centro de Investigación Biomédica en Red (CIBER-ISCIII) , Fundación INCLIVA , Universitat de València Estudi General
IPC: G01N33/68
Abstract: The present invention proposes a novel method for the detection of circulating histones H3 and H2B in plasma from sepsis or septic shock (SS) patients, based on mass spectrometry-based methods, in particular based on multiple reaction monitoring targeted mass spectrometry (MRM-MS). Such methods allow quantification of histones using an internal standard and show strong specificity and sensitivity values.
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公开(公告)号：US10508266B2
公开(公告)日：2019-12-17
申请号：US15576798
申请日：2016-05-24
Applicant: UNIVERSITAT DE VALÈNCIA (ESTUDI GENERAL) , INSTITUTO VALENCIANO DE INVESTIGACIONES AGRARIAS (IVIA)
Abstract: A method is for prevention and/or biological control of wilt caused by Ralstonia solanacearum, by use of suitable bacteriophages. In addition a method uses the structural characterisation, genome sequence and activity of three specific lytic bacteriophages of R. solanacearum. Podovirus presents an elevated stability between 4° C. and 30° C. in an aqueous medium in the absence of a host. As a result of the high level of stability, lytic activity, elevated specificity towards R. solanacearum and the absence of activity against the microbiota associated with the plants to be protected, bacteriophages are used for the biological control of R. solanacearum in river courses and irrigation water, as well as in a method for preventing and/or controlling the wilt produced by the bacteria, in which at least one of the bacteriophages, or combinations thereof, are delivered to the plants and/or the soil in the irrigation water.
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Patent Agency Ranking
公开(公告)号：US12253689B2
公开(公告)日：2025-03-18
申请号：US18251154
申请日：2021-10-27
Applicant: UNIVERSITAT DE VALÈNCIA
Inventor： Manuel Martínez Corral , Genaro Saavedra Tortosa , Gabriele Scrofani , Emilio Sánchez Ortiga
Abstract: The present invention relates to a multi perspective photography camera device, for capturing perspective images of a macroscopic 3D scene, comprising: —a hollow casing (10a-10b, 11, 13) housing: —a lens array (8) to be placed at a conjugate plane of an aperture diaphragm (2) of a photographic objective (OB), between the photographic objective (OB) and a photosensitive pixel array sensor (9), to simultaneously receive and transmit to the sensor (9) light representative of a plurality of different perspectives of the macroscopic 3D scene (S), one perspective per array lens; —a field diaphragm (5) to be placed at a plane where an image provided by said photographic objective (OB) is to be formed; and—a converging lens (6) having a focal length fR, and that is placed between the field diaphragm (5) and the lens array (8), at a distance equal to fR from the field diaphragm (5).
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公开(公告)号：US12116575B2
公开(公告)日：2024-10-15
申请号：US18322487
申请日：2023-05-23
Applicant: Universitat de València , ARTHEX BIOTECH S.L.
Inventor： Rubén Artero Allepuz , Nerea Moreno Cervera , Irene González Martínez , Estefanía Cerro Herreros , Eric G. Marcusson , María Beatriz Llamusí Troisi
IPC: C12N15/113 , A61P21/00
CPC classification number: C12N15/113 , A61P21/00 , C12N2310/141 , C12N2310/31
Abstract: The invention provides oligonucleotide and/or oligonucleotide analogue molecules that are antagonists of a microRNA, preferably antagonists of human microRNAs hsa-miR-23b-3p and hsa-miR-218-5p, that comprise a mixture of phosphorothioate and phosphodiester linkages, and that are conjugated to at least one oleic acid molecule. Inhibiting these microRNAs allows to increase the endogenous levels of the corresponding proteins MBNL1 and/or MBNL2. The present invention further provides compositions comprising said oligonucleotides and/or oligonucleotide analogue molecules and their uses for the treatment and prevention of DM in a subject in need thereof.
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公开(公告)号：US20240319187A1
公开(公告)日：2024-09-26
申请号：US18556560
申请日：2022-03-31
Inventor： Ángel MAQUIEIRA CATALA , David GIMENEZ ROMERO , Augusto Miguel JUSTE DOLZ , Sergi Beñat MORAIS EZQUERRO , Amadeo SENA TORRALBA , Luis Antonio TORTAJADA GENARO , Maria José BAÑULS POLO , Maria Isabel LUCIO BENITO , Maria Estrella FERNÁNDEZ SÁNCHEZ , Yeray PALLÁS TAMARIT
IPC: G01N33/569 , G01G3/13 , G01G3/16 , G01N1/22 , G01N29/036 , G01N33/497
CPC classification number: G01N33/56983 , G01G3/13 , G01G3/16 , G01N1/2214 , G01N29/036 , G01N33/497 , G01N2333/165
Abstract: A biosensor and virusometer allows continuous, real-time detection of viral particles of pathogens, especially SARS-COV-2, both in indoor and outdoor air and in liquid samples in which the pathogen(s) have been collected. The biosensor includes a quartz crystal microbalance coated with a layer having one or more antibodies specific to one or more pathogens to be detected. A first virusometer is described, including an aerosol collector, which makes it possible to increase the concentration of pathogens before taking them to the biosensor. A second virusometer has a receptacle, divided into a first cavity wherein air exhaled by a user is collected and concentrated, and a second cavity wherein the biosensor is arranged.
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公开(公告)号：US20240318261A1
公开(公告)日：2024-09-26
申请号：US18574568
申请日：2022-06-27
Applicant: FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNIDAD VALENCIANA. , UNIVERSITAT DE VALÈNCIA
IPC: C12Q1/6886
CPC classification number: C12Q1/6886 , C12Q2600/154
Abstract: The present invention relates to novel differentially methylated genetic elements associated with cutaneous Spitzoid tumors. The invention also relates to improved methods for classifying said tumors.
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公开(公告)号：US11740245B2
公开(公告)日：2023-08-29
申请号：US16346978
申请日：2017-11-06
Applicant: Centro de Investigación Biomédica en Red (CIBER-ISCIII) , Fundación INCLIVA , Universitat de València Estudi General
IPC: G01N33/68
CPC classification number: G01N33/6848 , G01N33/6893 , G01N2800/26 , G01N2800/56
Abstract: The present invention proposes a novel method for the detection of circulating histones H3 and H2B in plasma from sepsis or septic shock (SS) patients, based on mass spectrometry-based methods, in particular based on multiple reaction monitoring targeted mass spectrometry (MRM-MS). Such methods allow quantification of histones using an internal standard and show strong specificity and sensitivity values.
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