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公开(公告)号：US20230018623A1
公开(公告)日：2023-01-19
申请号：US17849660
申请日：2022-06-26
Applicant: VANRX PHARMASYSTEMS INC.
Inventor： Marcin Czeslaw CICHY , Carlos Alberto DIAZ GUERRERO
Abstract: The present invention involves a rotary peristaltic pump and associated method employing the relaxation of pressure on flexible tubing between the rotor and stator of the pump to restore the rotor to a start angle while a valve on the output of the pump is closed to avoid progress of fluid through the system. Three different implementations of the pump and method are presented including reciprocating the stator, reciprocating the rotor, and retracting the idler rollers of the rotor into the rotor to relieve the pressure on the flexible tubing. A controller ensures the appropriate switching and timing of the valve and rotor of the pump. The pump and associated method are directed to the precision dispensing of pharmaceutical fluids into containers, including containers held in container nests.
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公开(公告)号：US11530064B2
公开(公告)日：2022-12-20
申请号：US17005178
申请日：2020-08-27
Applicant: Vanrx Pharmasystems Inc.
Inventor： Carlos Alberto Diaz Guerrero
Abstract: A system is presented for monitoring and controlling in a sterilizable environment the peeling of a cover from a tub sealed by the cover. The system employs a platform having a fiducial source locating structure for holding the tub, a cover removal station disposed to engage with the cover and to peel the cover from the tub, a light source disposed to illuminate a portion of the platform proximate the cover removal station, a light sensor sensitive to light from the light source and disposed to preferentially collect and measure light diffusely reflected from the illuminated portion of the platform, and a controller with software to operate the system. An associated method for monitoring and controlling the peeling of the cover involves moving a peeled portion of the cover into a predetermined peeling monitor zone within the illuminated portion of the platform, and measuring an intensity of light from the light source diffusely reflected specifically from the peeling monitor zone. The positioning of the elements of the system and the peeling monitor zone allow measured light intensity to be employed as a control measure for the peeling process.
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公开(公告)号：US20220111510A1
公开(公告)日：2022-04-14
申请号：US17486693
申请日：2021-09-27
Applicant: VANRX PHARMASYSTEMS INC.
Inventor： Ross M. GOLD , Jeroen IMMERZEEL , Steve Sang Joon PARK , Christopher A. PROCYSHYN
Abstract: A hermetically sealed multi-axis articulated arm apparatus for use within a sealable isolator chamber comprises a rotational shaft that passes through an opening in the chamber, a sealing member disposed within the chamber for sealing the shaft to an inner surface of the chamber, a plurality of interconnected hermetically sealed arm segments, operably attached to the linear motion shaft; an end effector operably attached to a terminal arm segment among the plurality of arm segments, and at least one fully enclosed drive system for driving and controlling the shaft and the plurality of arm segments. The linear motion shaft may have a sealing member in the form of a bellows. The materials for the parts of the apparatus exposed to the atmosphere of the chamber are compatible with an aseptic and cleanable environment and the surfaces of the arm segments are shaped to avoid pooling of contaminants.
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公开(公告)号：US11065759B2
公开(公告)日：2021-07-20
申请号：US14377696
申请日：2013-02-08
Applicant: VANRX PHARMASYSTEMS, INC.
Inventor： Ross M. Gold , Christopher Procyshyn , Jeroen Immerzeel , Steve Sang Joon Park
Abstract: A hermetically sealed multi-axis articulated arm apparatus for use within a sealable isolator chamber is disclosed. In one general aspect, it comprises a rotational shaft that passes through an opening in the chamber, a sealing member disposed within the chamber for sealing the shaft to an inner surface of the chamber, interconnected hermetically sealed arm segments operably attached to the linear motion shaft; an end effector operably attached to a terminal arm segment among the arm segments, and at least one fully enclosed drive system for driving and controlling the shaft and the arm segments. The rotational shaft can further be a linear motion shaft for which the sealing member is a bellows. The materials for the parts of the apparatus exposed to the atmosphere of the chamber can be compatible with an aseptic and cleanable environment and the surfaces of the arm segments can be shaped to avoid pooling of contaminants.
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公开(公告)号：US20210070481A1
公开(公告)日：2021-03-11
申请号：US17008458
申请日：2020-08-31
Applicant: VANRX PHARMASYSTEMS INC.
Inventor： Christopher A. PROCYSHYN , Juvenal NAING , John SENGER , Marcin Czeslaw CICHY
Abstract: Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.
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Patent Agency Ranking
6.发明授权公开(公告)号：US10857666B2
公开(公告)日：2020-12-08
申请号：US16223003
申请日：2018-12-17
Applicant: VANRX PHARMASYSTEMS INC.
Inventor： Christopher A. Procyshyn , Jeroen Immerzeel , Steve Sang Joon Park , Ross M. Gold
Abstract: A hermetically sealed multi-axis articulated arm apparatus for use within a sealable isolator chamber comprises a rotational shaft that passes through an opening in the chamber, a sealing member disposed within the chamber for sealing the shaft to an inner surface of the chamber, a plurality of interconnected hermetically sealed arm segments, operably attached to the linear motion shaft; an end effector operably attached to a terminal arm segment among the plurality of arm segments, and at least one fully enclosed drive system for driving and controlling the shaft and the plurality of arm segments. The linear motion shaft may have a sealing member in the form of a bellows. The materials for the parts of the apparatus exposed to the atmosphere of the chamber are compatible with an aseptic and cleanable environment and the surfaces of the arm segments are shaped to avoid pooling of contaminants.
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公开(公告)号：US20200377241A1
公开(公告)日：2020-12-03
申请号：US16430383
申请日：2019-06-03
Applicant: VANRX PHARMASYSTEMS INC.
Inventor： Marcin Czeslaw CICHY , Carlos Alberto DIAZ GUERRERO
Abstract: The present invention involves a rotary peristaltic pump and associated method employing the relaxation of pressure on flexible tubing between the rotor and stator of the pump to restore the rotor to a start angle while a valve on the output of the pump is closed to avoid progress of fluid through the system. Three different implementations of the pump and method are presented including reciprocating the stator, reciprocating the rotor, and retracting the idler rollers of the rotor into the rotor to relieve the pressure on the flexible tubing. A controller ensures the appropriate switching and timing of the valve and rotor of the pump. The pump and associated method are directed to the precision dispensing of pharmaceutical fluids into containers, including containers held in container nests.
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公开(公告)号：US20190381652A1
公开(公告)日：2019-12-19
申请号：US16223003
申请日：2018-12-17
Applicant: VANRX PHARMASYSTEMS INC.
Inventor： Christopher A. PROCYSHYN , Jeroen IMMERZEEL , Steve Sang Joon PARK , Ross M. GOLD
Abstract: A hermetically sealed multi-axis articulated arm apparatus for use within a sealable isolator chamber comprises a rotational shaft that passes through an opening in the chamber, a sealing member disposed within the chamber for sealing the shaft to an inner surface of the chamber, a plurality of interconnected hermetically sealed arm segments, operably attached to the linear motion shaft; an end effector operably attached to a terminal arm segment among the plurality of arm segments, and at least one fully enclosed drive system for driving and controlling the shaft and the plurality of arm segments. The linear motion shaft may have a sealing member in the form of a bellows. The materials for the parts of the apparatus exposed to the atmosphere of the chamber are compatible with an aseptic and cleanable environment and the surfaces of the arm segments are shaped to avoid pooling of contaminants.
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9.发明申请公开(公告)号：US20190056420A1
公开(公告)日：2019-02-21
申请号：US15898653
申请日：2018-02-18
Applicant: VANRX PHARMASYSTEMS INC.
Inventor： Christopher PROCYSHYN , Marcin CICHY
IPC: G01N35/10 , B01L1/04 , G01N35/00 , B65B3/04 , A61J1/12 , B65B3/00 , B65B55/12 , B01L3/02 , A61J1/14 , A61J1/20
Abstract: A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path and a swab within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated. The apparatus allows the fluid path to be unprotected without the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontamination is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated. In some embodiments the fluid path comprises a fill needle that can removably and aseptically be sealed with a disposable monolithic injection moulded polymeric fill needle sheath. The apparatus and method further allow for the use of a swab disposed in a swab holder that is aseptically and removably sealable to a swab cap to protect the swab against decontamination vapors.
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10.发明申请公开(公告)号：US20190054459A1
公开(公告)日：2019-02-21
申请号：US15898641
申请日：2018-02-18
Applicant: VANRX PHARMASYSTEMS INC.
Inventor： Christopher A. PROCYSHYN , Jeroen IMMERZEEL , Steve Sang Joon PARK
Abstract: A controlled environment enclosure comprises a robotic arm manipulation system used to protect and unprotect a fluid path within the controlled environment enclosure. The apparatus allows the fluid path to be protected against dangerous decontamination vapors and chemicals before the controlled environment enclosure is decontaminated, the method not requiring the use of gloves or other means that degrade the integrity of the controlled environment enclosure. The apparatus similarly allows the fluid path to be unprotected for use without the use of gloves, the method not requiring the use of gloves or other means that degrade the integrity of the controlled environment enclosure when decontaminated is completed. The apparatus and method allow for the protecting, unprotecting and decontaminating sequences to be automated
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