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公开(公告)号：US20170335408A1
公开(公告)日：2017-11-23
申请号：US15459666
申请日：2017-03-15
Applicant: Abbott Laboratories
Inventor： Frank Pawlowski , Joseph P. Skinner , Jack Kessler , Sonal Sadaria Nana
IPC: C12Q1/68 , B01L9/00 , G01N30/88 , G01N35/00 , G01N33/569
CPC classification number: C12Q1/6888 , B01L9/523 , C12Q1/6806 , G01N30/88 , G01N33/48 , G01N33/56983 , G01N35/00 , G01N35/00584 , G01N2035/00326 , C12Q2527/113 , C12Q2531/113 , C12Q2545/114 , C12Q2561/113
Abstract: The instant disclosure provides methods of multi-assay processing and multi-assay analysis. Such multi-assay processing and analysis pertain to automated detection of target nucleic acids, e.g., as performed in the clinical setting for diagnostic purposes. Also provided are common assay timing protocols derived from a variety of individual nucleic acid amplification and analysis protocols and modified to prevent resource contention. The instant disclosure also provides systems and devices for practicing the methods as described herein.
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公开(公告)号：US20170269114A1
公开(公告)日：2017-09-21
申请号：US15460157
申请日：2017-03-15
Applicant: Abbott Laboratories
Inventor： Jason E. Bryant , Daniel P. Casazza , Daniel J. Harris , Brett W. Johnson , Sonal Sadaria Nana , Timothy J. Patno , Frank Pawlowski , David M. Peters , Joseph P. Skinner , Mark Talmer
Abstract: Aspects of the present disclosure include sample analysis methods and systems. According to certain embodiments, provided are methods of analyzing samples in an automated sample analysis system. The methods include introducing samples and sample preparation cartridges into the system, isolating and purifying an analyte (e.g., nucleic acids and/or proteins) present in the samples at a sample preparation station, and performing analyte detection assays in assay mixtures that include the purified analyte. Also provided are automated sample analysis systems that find use, e.g., in performing the methods of the present disclosure. In certain aspects, the methods and systems provide for continuous operator access during replenishment or removal of one or any combination of samples, bulk fluids, reagents, commodities, waste, and/or the like.
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公开(公告)号：US09005901B2
公开(公告)日：2015-04-14
申请号：US13833365
申请日：2013-03-15
Applicant: Abbott Laboratories
Inventor： Susan Gayda , Qiaoqiao Ruan , Joseph P. Skinner , Sergey Y. Tetin
IPC: G01N33/53 , G01N35/00 , G01N33/543
CPC classification number: G01N35/00693 , G01N33/54306
Abstract: Provided herein are kits and methods for assays with internal calibration.
Abstract translation: 本文提供了用于具有内部校准的测定的试剂盒和方法。
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公开(公告)号：US20220228990A1
公开(公告)日：2022-07-21
申请号：US17711375
申请日：2022-04-01
Applicant: Abbott Laboratories
Inventor： Qiaoqiao Ruan , Sylvia C. Saldana , Joseph P. Skinner , Sergey Y. Tetin
IPC: G01N21/64 , G01N33/543
Abstract: A method for analyzing the results of a ligand-receptor binding assay comprising the steps of: (a) providing the results of a ligand-receptor binding assay; and (b) qualifying the results of a ligand-receptor binding assay. More particularly, the ligand-receptor binding assay involves the steps of combining appropriate reagents in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is directly proportional to the amount of ligand present in the sample. Alternatively, the ligand-receptor binding assay involves the steps of combining appropriate reagents to perform a ligand-receptor binding assay in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is inversely proportional to the amount of analyte present in the sample.
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公开(公告)号：US11719641B2
公开(公告)日：2023-08-08
申请号：US17711375
申请日：2022-04-01
Applicant: Abbott Laboratories
Inventor： Qiaoqiao Ruan , Sylvia C. Saldana , Joseph P. Skinner , Sergey Y. Tetin
IPC: G01N21/64 , G01N33/543
CPC classification number: G01N21/6456 , G01N33/543
Abstract: A method for analyzing the results of a ligand-receptor binding assay comprising the steps of:
(a) providing the results of a ligand-receptor binding assay; and
(b) qualifying the results of a ligand-receptor binding assay.
More particularly, the ligand-receptor binding assay involves the steps of combining appropriate reagents in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is directly proportional to the amount of ligand present in the sample. Alternatively, the ligand-receptor binding assay involves the steps of combining appropriate reagents to perform a ligand-receptor binding assay in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is inversely proportional to the amount of analyte present in the sample.-
Patent Agency Ranking
公开(公告)号：US11307141B2
公开(公告)日：2022-04-19
申请号：US16237098
申请日：2018-12-31
Applicant: Abbott Laboratories
Inventor： Qiaoqiao Ruan , Sylvia C. Saldana , Joseph P. Skinner , Sergey Y. Tetin
IPC: G01N21/64 , G01N33/543
Abstract: A method for analyzing the results of a ligand-receptor binding assay comprising the steps of: (a) providing the results of a ligand-receptor binding assay; and (b) qualifying the results of a ligand-receptor binding assay. More particularly, the ligand-receptor binding assay involves the steps of combining appropriate reagents in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is directly proportional to the amount of ligand present in the sample. Alternatively, the ligand-receptor binding assay involves the steps of combining appropriate reagents to perform a ligand-receptor binding assay in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is inversely proportional to the amount of analyte present in the sample.
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公开(公告)号：US10942179B2
公开(公告)日：2021-03-09
申请号：US16057818
申请日：2018-08-08
Applicant: ABBOTT LABORATORIES
Inventor： Barry L. Dowell , Susan Gayda , Qiaoqiao Ruan , Joseph P. Skinner , Sergey Y. Tetin
IPC: G01N33/543 , G01N33/53
Abstract: Provided herein are assays and kits useful for avoiding “prozone phenomenon” or “hook effect” and which expand the range of accurately measurable analyte concentrations.
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公开(公告)号：US20190195798A1
公开(公告)日：2019-06-27
申请号：US16237098
申请日：2018-12-31
Applicant: Abbott Laboratories
Inventor： Qiaoqiao Ruan , Sylvia C. Saldana , Joseph P. Skinner , Sergey Y. Tetin
IPC: G01N21/64
CPC classification number: G01N21/6456 , G01N33/543
Abstract: A method for analyzing the results of a ligand-receptor binding assay comprising the steps of: (a) providing the results of a ligand-receptor binding assay; and (b) qualifying the results of a ligand-receptor binding assay. More particularly, the ligand-receptor binding assay involves the steps of combining appropriate reagents in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is directly proportional to the amount of ligand present in the sample. Alternatively, the ligand-receptor binding assay involves the steps of combining appropriate reagents to perform a ligand-receptor binding assay in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is inversely proportional to the amount of analyte present in the sample.
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公开(公告)号：US10073090B2
公开(公告)日：2018-09-11
申请号：US14842834
申请日：2015-09-02
Applicant: ABBOTT LABORATORIES
Inventor： Barry L. Dowell , Susan Gayda , Qiaoqiao Ruan , Joseph P. Skinner , Sergey Y. Tetin
IPC: G01N33/53 , G01N33/543
CPC classification number: G01N33/54393 , G01N33/5306 , G01N33/54306
Abstract: Provided herein are assays and kits useful for avoiding “prozone phenomenon” or “hook effect” and which expand the range of accurately measurable analyte concentrations.
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公开(公告)号：US20170268038A1
公开(公告)日：2017-09-21
申请号：US15460186
申请日：2017-03-15
Applicant: Abbott Laboratories
Inventor： Timothy P. Henning , Joseph P. Skinner , Jody L. Keck , Chadwick M. Dunn , Wesley W. Addison, II , Timothy J. Patno , Sonal Sadaria Nana , Mark Talmer , Austin Lines , Daniel J. Harris , Eric D. Yeaton
CPC classification number: C12Q1/6806 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/525 , B01L2200/10 , B01L2300/042 , B01L2300/0829 , B01L2300/0848 , B01L2300/0861 , B01L2400/0478 , C12N15/1013 , C12Q2563/143 , C12Q2563/149
Abstract: Aspects of the present disclosure include sample preparation cartridges including a frame that includes a plurality of wells integrated therewith, where the plurality of wells have a closed bottom and an open top. The frame further includes an opening within the frame having a reaction vessel (RV) or RV cap removably disposed therein, where the plurality of wells and the opening are linearly arranged relative to each other. Also provided are sample preparation cartridges that include a frame, two or more cartridge separation projections on a top side of the frame, and two or more cartridge separation projections on a bottom side of the frame. The cartridge separation projections separate the cartridge and a different cartridge when the cartridge and different cartridge are stacked. Methods of using the sample preparation cartridges, as well as nucleic acid sample preparation units that include the sample preparation cartridges, are also provided.
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