公开(公告)号：US10071034B2

公开(公告)日：2018-09-11

申请号：US14702607

申请日：2015-05-01

Applicant: Amyris, Inc.

Inventor： Ross Keating Eppler ,  Karl Fisher ,  Roberto Vazquez

IPC: A61K8/31 ,  A61Q19/00 ,  A61Q1/04 ,  A61Q5/00 ,  C11D3/18 ,  A61Q5/06

CPC classification number: A61K8/31 ,  A61Q1/04 ,  A61Q5/00 ,  A61Q5/065 ,  A61Q19/00 ,  C11D3/184

Abstract: Provided herein are compositions comprising partially hydrogenated farnesene. In certain embodiments, the compositions are useful as solvents, degreasers, cleaning products, personal care products, and for other uses. Also provided herein are methods of making the compositions and methods of their use.

公开(公告)号：US20130310617A1

公开(公告)日：2013-11-21

申请号：US13951137

申请日：2013-07-25

Applicant: AMYRIS, INC.

Inventor： Nicholas L. Ohler ,  Roberto Vazquez

IPC: C07C5/03

CPC classification number: C07C5/03 ,  C07C7/20 ,  C07C11/21 ,  C07C2523/44 ,  C07C2523/755 ,  C10G45/00 ,  C10G53/04 ,  C10G53/08 ,  C10G67/04 ,  C10G67/06 ,  C10G2300/1011 ,  C10G2300/1055 ,  C10G2300/201 ,  C10G2300/4081 ,  C10G2300/802 ,  C10G2400/22 ,  C10L1/04 ,  C10L1/1608 ,  C10L1/1832 ,  Y02P30/20 ,  C07C9/16

Abstract: Processes and systems for stabilization and subsequent hydrogenation of an immiscible olefin are described. In certain embodiments, the hydrogenation is conducted in a fixed bed reactor in presence of a hydrogenation catalyst.

Abstract translation: 描述了不混溶烯烃的稳定化和随后氢化的方法和系统。 在某些实施方案中，氢化在氢化催化剂存在下在固定床反应器中进行。

公开(公告)号：US10183901B2

公开(公告)日：2019-01-22

申请号：US15458907

申请日：2017-03-14

Applicant: AMYRIS, INC.

Inventor： Nicholas L. Ohler ,  Roberto Vazquez

IPC: C07C1/00 ,  C07C5/03 ,  C07C7/20 ,  C07C11/21 ,  C10G45/00 ,  C10G53/04 ,  C10G53/08 ,  C10G67/04 ,  C10G67/06 ,  C10L1/04 ,  C10L1/16 ,  C10L1/183

Abstract: Methods and compositions for stabilization and subsequent hydrogenation of a microbial-derived immiscible olefin are described. The methods comprise separating immiscible olefin from a mixture comprising an aqueous solution, microbial cells and immiscible olefin thereby forming a crude olefin composition; purifying the crude olefin composition thereby forming a purified olefin composition; and adding a phenolic antioxidant to the purified olefin composition wherein the phenolic antioxidant is a phenol derivative containing an unfused phenyl ring with one or more hydroxyl substituents. The methods further comprise reacting the purified olefin composition with hydrogen in the presence of a hydrogen catalyst such that hydrogen saturates at least one double bond in the olefin. Hydrogenated compositions produced by the methods are further provided.

公开(公告)号：US20150315520A1

公开(公告)日：2015-11-05

申请号：US14702607

申请日：2015-05-01

Applicant: Amyris, Inc.

Inventor： Ross Keating Eppler ,  Karl Fisher ,  Roberto Vazquez

IPC: C11D3/18 ,  A61Q1/04 ,  A61Q5/00 ,  A61K8/31 ,  A61Q19/00

CPC classification number: A61K8/31 ,  A61Q1/04 ,  A61Q5/00 ,  A61Q5/065 ,  A61Q19/00 ,  C11D3/184

Abstract: Provided herein are compositions comprising partially hydrogenated farnesene. In certain embodiments, the compositions are useful as solvents, degreasers, cleaning products, personal care products, and for other uses. Also provided herein are methods of making the compositions and methods of their use.

Abstract translation: 本文提供了包含部分氢化法呢烯的组合物。 在某些实施方案中，组合物可用作溶剂，脱脂剂，清洁产品，个人护理产品和用于其它用途。 本文还提供了制备其组合物和使用方法。

公开(公告)号：US20170283346A1

公开(公告)日：2017-10-05

申请号：US15458907

申请日：2017-03-14

Applicant: AMYRIS, INC.

Inventor： Nicholas L. Ohler ,  Roberto Vazquez

IPC: C07C5/03 ,  C10G45/00 ,  C10L1/04 ,  C10G53/08 ,  C10G67/04 ,  C10G67/06 ,  C07C11/21 ,  C10G53/04

CPC classification number: C07C5/03 ,  C07C7/20 ,  C07C11/21 ,  C07C2523/44 ,  C07C2523/755 ,  C10G45/00 ,  C10G53/04 ,  C10G53/08 ,  C10G67/04 ,  C10G67/06 ,  C10G2300/1011 ,  C10G2300/1055 ,  C10G2300/201 ,  C10G2300/4081 ,  C10G2300/802 ,  C10G2400/22 ,  C10L1/04 ,  C10L1/1608 ,  C10L1/1832 ,  Y02P30/20 ,  C07C9/16

Abstract: Methods and compositions for stabilization and subsequent hydrogenation of a microbial-derived immiscible olefin are described. The methods comprise separating immiscible olefin from a mixture comprising an aqueous solution, microbial cells and immiscible olefin thereby forming a crude olefin composition; purifying the crude olefin composition thereby forming a purified olefin composition; and adding a phenolic antioxidant to the purified olefin composition wherein the phenolic antioxidant is a phenol derivative containing an unfused phenyl ring with one or more hydroxyl substituents. The methods further comprise reacting the purified olefin composition with hydrogen in the presence of a hydrogen catalyst such that hydrogen saturates at least one double bond in the olefin. Hydrogenated compositions produced by the methods are further provided.

公开(公告)号：US20130310615A1

公开(公告)日：2013-11-21

申请号：US13951160

申请日：2013-07-25

Applicant: AMYRIS, INC.

Inventor： Nicholas L. Ohler ,  Roberto Vazquez

IPC: C07C5/03

CPC classification number: C07C5/03 ,  C07C7/20 ,  C07C11/21 ,  C07C2523/44 ,  C07C2523/755 ,  C10G45/00 ,  C10G53/04 ,  C10G53/08 ,  C10G67/04 ,  C10G67/06 ,  C10G2300/1011 ,  C10G2300/1055 ,  C10G2300/201 ,  C10G2300/4081 ,  C10G2300/802 ,  C10G2400/22 ,  C10L1/04 ,  C10L1/1608 ,  C10L1/1832 ,  Y02P30/20 ,  C07C9/16

Abstract: Processes and systems for stabilization and subsequent hydrogenation of an immiscible olefin are described. In certain embodiments, the hydrogenation is conducted in a fixed bed reactor in presence of a hydrogenation catalyst.

公开(公告)号：US10894754B2

公开(公告)日：2021-01-19

申请号：US16228567

申请日：2018-12-20

Applicant: AMYRIS, INC.

Inventor： Nicholas L. Ohler ,  Roberto Vazquez

IPC: C07C5/03 ,  C07C7/20 ,  C07C11/21 ,  C10G45/00 ,  C10G53/04 ,  C10G53/08 ,  C10G67/04 ,  C10G67/06 ,  C10L1/04 ,  C10L1/16 ,  C10L1/183

Abstract: Processes and systems for stabilization and subsequent hydrogenation of an immiscible olefin are described. In certain embodiments, the hydrogenation is conducted in a fixed bed reactor in presence of a hydrogenation catalyst.

公开(公告)号：US20190119184A1

公开(公告)日：2019-04-25

申请号：US16228567

申请日：2018-12-20

Applicant: AMYRIS, INC.

Inventor： Nicholas L. Ohler ,  Roberto Vazquez

IPC: C07C5/03 ,  C10G67/06 ,  C10L1/04 ,  C07C7/20 ,  C07C11/21 ,  C10G45/00 ,  C10G53/04 ,  C10G53/08 ,  C10G67/04

Abstract: Processes and systems for stabilization and subsequent hydrogenation of an immiscible olefin are described. In certain embodiments, the hydrogenation is conducted in a fixed bed reactor in presence of a hydrogenation catalyst.

公开(公告)号：US09611189B2

公开(公告)日：2017-04-04

申请号：US13951137

申请日：2013-07-25

Applicant: AMYRIS, INC.

Inventor： Nicholas L. Ohler ,  Roberto Vazquez

IPC: C07C1/00 ,  C07C5/03 ,  C07C7/20 ,  C07C11/21 ,  C10G45/00 ,  C10G53/04 ,  C10G53/08 ,  C10G67/04 ,  C10G67/06 ,  C10L1/04 ,  C10L1/16 ,  C10L1/183

CPC classification number: C07C5/03 ,  C07C7/20 ,  C07C11/21 ,  C07C2523/44 ,  C07C2523/755 ,  C10G45/00 ,  C10G53/04 ,  C10G53/08 ,  C10G67/04 ,  C10G67/06 ,  C10G2300/1011 ,  C10G2300/1055 ,  C10G2300/201 ,  C10G2300/4081 ,  C10G2300/802 ,  C10G2400/22 ,  C10L1/04 ,  C10L1/1608 ,  C10L1/1832 ,  Y02P30/20 ,  C07C9/16

Abstract: Methods and compositions for stabilization and subsequent hydrogenation of a microbial-derived immiscible olefin are described. The methods comprise providing a feed stream to the inlet of a reactor, wherein the feed stream comprises a microbial-derived immiscible olefin composition stabilized with a phenolic antioxidant which is a phenol derivative containing an unfused phenyl ring with one or more hydroxyl substituents. The methods further comprise contacting the feed stream with hydrogen in the presence of a hydrogenation catalyst at a temperature of about 20° C. or greater, and generating a product stream comprising a hydrogenated immiscible olefin composition. The microbial-derived immiscible olefin composition stabilized with the phenolic antioxidant remains stable over time, and its hydrogenation reaction time and process are improved.