公开(公告)号：US20170059563A1

公开(公告)日：2017-03-02

申请号：US15308330

申请日：2015-05-01

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Joseph Smith ,  Jennifer Blain Christen ,  Karen Anderson ,  Benjamin Katchman

IPC: G01N33/543 ,  G01N21/64 ,  A61B5/00 ,  B01L3/00

CPC classification number: G01N33/54366 ,  A61B5/0071 ,  A61B5/6802 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/025 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0825 ,  B01L2300/087 ,  B01L2300/123 ,  G01N21/05 ,  G01N21/6428 ,  G01N21/6454 ,  G01N33/54373 ,  G01N2021/6439 ,  G01N2201/0221

Abstract: A fully integrated miniaturized optical biosensor and methods of making the same are disclosed. The biosensor may include a fluid transport system and an optical system.

Abstract translation: 公开了一种完全集成的小型化光学生物传感器及其制造方法。 生物传感器可以包括流体输送系统和光学系统。

公开(公告)号：US11543407B2

公开(公告)日：2023-01-03

申请号：US15308330

申请日：2015-05-01

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Joseph Smith ,  Jennifer Blain Christen ,  Karen Anderson ,  Benjamin Katchman

IPC: G01N33/543 ,  B01L3/00 ,  G01N21/64 ,  G01N21/05 ,  A61B5/00

Abstract: A fully integrated miniaturized optical biosensor and methods of making the same are disclosed. The biosensor may include a fluid transport system and an optical system.

公开(公告)号：US10591474B2

公开(公告)日：2020-03-17

申请号：US15579038

申请日：2016-05-06

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Benjamin Katchman ,  Karen Anderson ,  Joseph Smith ,  Jennifer Blain Christen

IPC: G01N33/543 ,  G01N33/58 ,  B01L3/00 ,  G01N21/64 ,  G01N33/68

Abstract: Systems and methods for low-cost point-of-care immunoassay are provided. The system comprises an emitter, two optical interference filters, a microscope slide, a photodiode detector, a circuit, and a measuring unit. The detector is placed upon the second filter, the slide, the first filter, and then the emitter. The emitter comprises non-organic light emitting diodes (LEDs) or organic light emitting diodes (OLEDs) that emits light of a first color. The slide is spotted with biofluid from a patient. Biomarkers in the biofluid is bound with immobilized fluorophores that emit light of a second color when stimulated by the light of the first color. The first and second filters band-pass the light of the first and second colors, respectively. The detector detects light of the second color. The current outputted from the detector is converted into a relatively-large output voltage by a circuit. A measuring unit measures the ramp time of the output voltage. The ramp time is to be used to determine the concentration of the fluorophores, which in turn is related to the concentration of the biomarkers.

公开(公告)号：US20180172681A1

公开(公告)日：2018-06-21

申请号：US15579038

申请日：2016-05-06

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Benjamin Katchman ,  Karen Anderson ,  Joseph Smith ,  Jennifer Blain Christen

IPC: G01N33/543 ,  G01N33/58 ,  G01N33/68 ,  B01L3/00 ,  G01N21/64

CPC classification number: G01N33/54373 ,  B01L3/502715 ,  G01N21/6428 ,  G01N33/54386 ,  G01N33/58 ,  G01N33/582 ,  G01N33/6857 ,  G01N2333/025

Abstract: Systems and methods for low-cost point-of-care immunoassay are provided. The system comprises an emitter, two optical interference filters, a microscope slide, a photodiode detector, a circuit, and a measuring unit. The detector is placed upon the second filter, the slide, the first filter, and then the emitter. The emitter comprises non-organic light emitting diodes (LEDs) or organic light emitting diodes (OLEDs) that emits light of a first color. The slide is spotted with biofluid from a patient. Biomarkers in the biofluid is bound with immobilized fluorophores that emit light of a second color when stimulated by the light of the first color. The first and second filters band-pass the light of the first and second colors, respectively. The detector detects light of the second color. The current outputted from the detector is converted into a relatively-large output voltage by a circuit. A measuring unit measures the ramp time of the output voltage. The ramp time is to be used to determine the concentration of the fluorophores, which in turn is related to the concentration of the biomarkers.

公开(公告)号：US10589124B2

公开(公告)日：2020-03-17

申请号：US15111952

申请日：2015-01-13

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Joseph Smith ,  Barry O'Brien ,  Yong-Kyun Lee ,  Edward Bawolek ,  Jennifer Blain Christen ,  Michael Goryll ,  Jitendran Muthuswamy ,  George R. Kunnen ,  David Allee

IPC: A61N5/06 ,  A61B5/04

Abstract: Systems and methods for stimulating neural tissue are disclosed. An array of optically emissive pixels is configured to deliver light to the neural tissue of a subject. Individual pixels within the array can be addressed to selectively illuminate a portion of the neural tissue when a neurological event occurs. The system can also include an array of microelectrodes in electrical communication with the array of pixels and a power source. A biocompatible substrate can be used to support the microelectrodes pixels, and the power source. A microelectrode circuit and a pixel circuit can also be supported by the biocompatible substrate.

公开(公告)号：US20160331994A1

公开(公告)日：2016-11-17

申请号：US15111952

申请日：2015-01-13

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Joseph Smith ,  Barry O'Brien ,  Yong-Kyn Lee ,  Edward Bawolek ,  Jennifer Blain Chrostam ,  Michael Gooryll ,  Jitendran Muthuswamy ,  George R. Kunnen ,  David Allee

IPC: A61N5/06 ,  A61B5/04

CPC classification number: A61N5/0622 ,  A61B5/04001 ,  A61N5/0601 ,  A61N2005/0612 ,  A61N2005/0626 ,  A61N2005/0653 ,  A61N2005/0663

Abstract: Systems and methods for stimulating neural tissue are disclosed. An array of optically emissive pixels is configured to deliver light to the neural tissue of a subject. Individual pixels within the array can be addressed to selectively illuminate a portion of the neural tissue when a neurological event occurs. The system can also include an array of microelectrodes in electrical communication with the array of pixels and a power source. A biocompatible substrate can be used to support the microelectrodes pixels, and the power source. A microelectrode circuit and a pixel circuit can also be supported by the biocompatible substrate.

Abstract translation: 公开了用于刺激神经组织的系统和方法。 光学发射像素的阵列被配置为将光传送到对象的神经组织。 当发生神经系统事件时，阵列内的各个像素可被寻址以选择性地照射神经组织的一部分。 该系统还可以包括与像素阵列电源通信的微电极阵列和电源。 可以使用生物相容性底物来支持微电极像素和电源。 微电极电路和像素电路也可以由生物相容性基板支撑。