公开(公告)号：US09656978B2

公开(公告)日：2017-05-23

申请号：US14431472

申请日：2013-10-09

Applicant: ASTON UNIVERSITY

Inventor： Martin Griffin ,  Daniel Rathbone ,  Leonas Eduard Badarau

IPC: A61K31/495 ,  A61P25/28 ,  A61P31/18 ,  A61P17/06 ,  A61P7/02 ,  A61P29/00 ,  C07D295/26 ,  C07D233/84 ,  C07D295/185 ,  C07D295/205

CPC classification number: C07D295/26 ,  C07D233/84 ,  C07D295/185 ,  C07D295/205

Abstract: The present invention relates to novel compounds of Formula I capable of inhibiting tissue transglutaminase, and uses of the same in medicine. In particular, the invention provides compounds for use in the treatment of prevention of disease and conditions such as fibrosis (e.g. cystic fibrosis), scarring, neurodegenerative diseases (e.g. Alzheimer's disease, Huntington's disease and Parkinson's disease), autoimmune diseases (e.g. multiple sclerosis and coeliac disease), thrombosis, proliferative disorders (e.g. cancers), AIDS, psoriasis and inflammation (e.g. chronic inflammatory diseases).

公开(公告)号：US20150259310A1

公开(公告)日：2015-09-17

申请号：US14431472

申请日：2013-10-09

Applicant: ASTON UNIVERSITY

Inventor： Martin Griffin ,  Daniel Rathbone ,  Leonas Eduard Badarau

IPC: C07D295/26 ,  C07D295/205

CPC classification number: C07D295/26 ,  C07D233/84 ,  C07D295/185 ,  C07D295/205

Abstract: The present invention relates to novel compounds of Formula I capable of inhibiting tissue transglutaminase, and uses of the same in medicine. In particular, the invention provides compounds for use in the treatment of prevention of disease and conditions such as fibrosis (e.g. cystic fibrosis), scarring, neurodegenerative diseases (e.g. Alzheimer's disease, Huntington's disease and Parkinson's disease), autoimmune diseases (e.g. multiple sclerosis and coeliac disease), thrombosis, proliferative disorders (e.g. cancers), AIDS, psoriasis and inflammation (e.g. chronic inflammatory diseases).

Abstract translation: 本发明涉及能够抑制组织转谷氨酰胺酶的新型式I化合物及其在医药中的用途。 特别地，本发明提供了用于治疗疾病和病症例如纤维化（例如囊性纤维化），瘢痕形成，神经变性疾病（例如阿尔茨海默氏病，亨廷顿病和帕金森病），自身免疫性疾病（例如多发性硬化和 乳糜泻），血栓形成，增殖性疾病（例如癌症），AIDS，牛皮癣和炎症（例如慢性炎性疾病）。