公开(公告)号：US10760939B2

公开(公告)日：2020-09-01

申请号：US16552783

申请日：2019-08-27

Applicant: Abbott Laboratories

Inventor： Lyle Yarnell ,  Michael Shawn Murphy

IPC: G01F23/28 ,  G01N35/10 ,  G01F23/00 ,  G01N1/14 ,  H04B1/03

Abstract: Liquid level sensing apparatus and related methods are disclosed. An example method includes moving a cannula to pierce a seal of a container to provide access to a liquid in a cavity of the container; moving a probe through a passageway of the cannula and into the cavity of the container; and when the probe is at least partially positioned in the cannula: providing a first signal to the probe to cause the probe to emit a first electrical field; and providing a second signal to the cannula to cause the cannula to emit a second electrical field.

公开(公告)号：US20200256843A1

公开(公告)日：2020-08-13

申请号：US16864672

申请日：2020-05-01

Applicant: ABBOTT LABORATORIES

Inventor： Jeffrey B. Huff ,  Mark A. Hayden ,  Peter J. Karabatsos ,  Andrew S. Schapals ,  Anthony S. Muerhoff ,  M. Felicia Bogdan ,  Thomas Leary ,  Shelley R. Holets-McCormack ,  Sophie Laurenson ,  Andrew T. Fischer ,  Richard Haack ,  Stefan Hershberger ,  Dustin House ,  Lei Qiao ,  M. Shawn Murphy ,  Mark R. Pope ,  Edna M. Prieto-Ballengee ,  QiaoQiao Ruan ,  Pathik Soni ,  Sergey Tetin ,  Lyle Yarnell

IPC: G01N33/487 ,  G01N33/53 ,  B01L3/00 ,  G01N33/543

Abstract: Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.

公开(公告)号：US11065352B2

公开(公告)日：2021-07-20

申请号：US15851199

申请日：2017-12-21

Applicant: Abbott Laboratories

Inventor： Patrick Fritchie ,  Pathik Soni ,  Lei Qiao ,  Dustin House ,  Lyle Yarnell ,  Edna Prieto-Ballengee ,  Cathy Forsythe ,  Michael Shawn Murphy ,  Andrew Fischer ,  Akanksha Sharma ,  Joseph Esposito ,  Matt Effinger ,  Michael Futer

IPC: A61L2/04 ,  H05B6/06 ,  H05B6/40 ,  A61L2/24 ,  H05B6/10 ,  H05B6/14

Abstract: Inductive heating systems and method of controlling the same to reduce biological carryover are disclosed herein. An example system includes an induction heater including a tank circuit. The example system includes a controller to drive the tank circuit to selectively oscillate at a resonant frequency for the tank circuit to inductively heat a work piece disposed proximate to the tank circuit.

公开(公告)号：US10401209B2

公开(公告)日：2019-09-03

申请号：US15629495

申请日：2017-06-21

Applicant: Abbott Laboratories

Inventor： Lyle Yarnell ,  Michael Shawn Murphy

IPC: G01F23/28 ,  G01F23/00 ,  G01N35/10 ,  H04B1/03 ,  G01N1/14

Abstract: Liquid level sensing apparatus are disclosed. An example liquid level sensing apparatus includes a cannula defining a body having a tip and an access channel. The tip to pierce a container, where the cannula is to be at least partially positioned in the container when the tip pierces the container. A probe is to be positioned in the access channel. A signal source is to electrically energize the probe and the cannula to cause the probe to emit a first signal and cause the cannula to emit a second signal.

公开(公告)号：US20180193498A1

公开(公告)日：2018-07-12

申请号：US15851199

申请日：2017-12-21

Applicant: Abbott Laboratories

Inventor： Patrick Fritchie ,  Pathik Soni ,  Lei Qiao ,  Dustin House ,  Lyle Yarnell ,  Edna Prieto-Ballengee ,  Cathy Forsythe ,  Michael Shawn Murphy ,  Andrew Fischer ,  Akanksha Sharma ,  Joseph Esposito ,  Matt Effinger ,  Michael Futer

IPC: A61L2/04 ,  H05B6/06 ,  H05B6/10 ,  H05B6/40 ,  A61L2/24

CPC classification number: A61L2/04 ,  A61L2/24 ,  A61L2202/14 ,  H05B6/06 ,  H05B6/101 ,  H05B6/108 ,  H05B6/14 ,  H05B6/40

Abstract: Inductive heating systems and method of controlling the same to reduce biological carryover are disclosed herein. An example system includes an induction heater including a tank circuit. The example system includes a controller to drive the tank circuit to selectively oscillate at a resonant frequency for the tank circuit to inductively heat a work piece disposed proximate to the tank circuit.

公开(公告)号：US11022598B2

公开(公告)日：2021-06-01

申请号：US15724213

申请日：2017-10-03

Applicant: ABBOTT LABORATORIES

Inventor： Jeffrey B. Huff ,  Mark A. Hayden ,  Peter J. Karabatsos ,  Andrew S. Schapals ,  Anthony S. Muerhoff ,  M. Felicia Bogdan ,  Thomas Leary ,  Shelley R. Holets-McCormack ,  Sophie Laurenson ,  Andrew T. Fischer ,  Richard Haack ,  Stefan Hershberger ,  Dustin House ,  Lei Qiao ,  M. Shawn Murphy ,  Mark R. Pope ,  Edna M. Prieto-Ballengee ,  QiaoQiao Ruan ,  Pathik Soni ,  Sergey Tetin ,  Lyle Yarnell

IPC: G01N33/487 ,  G01N33/543 ,  G01N33/53 ,  B01L3/00

Abstract: Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.

公开(公告)号：US20180095067A1

公开(公告)日：2018-04-05

申请号：US15724200

申请日：2017-10-03

Applicant: Abbott Laboratories

Inventor： Jeffrey B. Huff ,  Mark A. Hayden ,  Peter J. Karabatsos ,  Andrew S. Schapals ,  Anthony S. Muerhoff ,  Felicia Bogdan ,  Thomas Leary ,  Shelley R. Holets-McCormack ,  Sophie Laurenson ,  Andrew T. Fischer ,  Richard Haack ,  Stefan Hershberger ,  Dustin House ,  Lei QIAO ,  M. Shawn Murphy ,  Mark R. Pope ,  Edna M. Prieto-Ballengee ,  QiaoQiao Ruan ,  Pathik Soni ,  Sergey Tetin ,  Lyle Yarnell ,  John M. Robinson

IPC: G01N33/487 ,  G01N33/53

CPC classification number: G01N33/48721 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/5438

Abstract: Integrated microfluidic and analyte detection devices are disclosed, along with methods of detecting target analytes. Digital microfluidic and analyte detection devices include a first substrate and a second substrate aligned generally parallel to each other to define a gap therebetween, the first substrate including a plurality of electrodes to generate electrical actuation forces on a liquid droplet disposed in the gap; at least one reagent disposed on at least one of the first substrate or the second substrate and configured to be carried by the liquid droplet; and an analyte detection device in fluid communication with the gap, wherein the plurality of electrodes are configured to move the liquid droplet towards the analyte detection device.

公开(公告)号：US20170370759A1

公开(公告)日：2017-12-28

申请号：US15629495

申请日：2017-06-21

Applicant: Abbott Laboratories

Inventor： Lyle Yarnell ,  Michael Shawn Murphy

IPC: G01F23/28 ,  G01F23/00 ,  G01N35/10

CPC classification number: G01F23/28 ,  G01F23/0061 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1079 ,  G01N2001/1418 ,  G01N2035/1025 ,  G01N2035/1093 ,  H04B1/03

Abstract: Liquid level sensing apparatus are disclosed. An example liquid level sensing apparatus includes a cannula defining a body having a tip and an access channel. The tip to pierce a container, where the cannula is to be at least partially positioned in the container when the tip pierces the container. A probe is to be positioned in the access channel. A signal source is to electrically energize the probe and the cannula to cause the probe to emit a first signal and cause the cannula to emit a second signal.

公开(公告)号：US20210338856A1

公开(公告)日：2021-11-04

申请号：US17375737

申请日：2021-07-14

Applicant: Abbott Laboratories

Inventor： Patrick Fritchie ,  Pathik Soni ,  Lei Qiao ,  Dustin House ,  Lyle Yarnell ,  Edna Prieto-Ballengee ,  Cathy Forsythe ,  Michael Shawn Murphy ,  Andrew Fischer ,  Akanksha Sharma ,  Joseph Esposito ,  Matt Effinger ,  Michael Futer

IPC: A61L2/04 ,  H05B6/10 ,  H05B6/14 ,  A61L2/24 ,  H05B6/06 ,  H05B6/40

Abstract: Inductive heating systems and method of controlling the same to reduce biological carryover are disclosed herein. An example system includes an induction heater including a tank circuit, the tank circuit including a work coil and a sense coil. The sense coil is to detect a magnetic field generated by the work coil and to output signals in response to the detection. The example system includes a controller to cause the tank circuit to oscillate at a resonant frequency in response to the signals and a power drive unit in communication with the controller and the induction heater. The power drive unit is to adjust power provided to the induction heater in response to the controller driving the tank circuit to oscillate at the resonant frequency.

公开(公告)号：US20190383659A1

公开(公告)日：2019-12-19

申请号：US16552783

申请日：2019-08-27

Applicant: Abbott Laboratories

Inventor： Lyle Yarnell ,  Michael Shawn Murphy

IPC: G01F23/28 ,  G01F23/00 ,  G01N35/10

Abstract: Liquid level sensing apparatus and related methods are disclosed. An example method includes moving a cannula to pierce a seal of a container to provide access to a liquid in a cavity of the container; moving a probe through a passageway of the cannula and into the cavity of the container; and when the probe is at least partially positioned in the cannula: providing a first signal to the probe to cause the probe to emit a first electrical field; and providing a second signal to the cannula to cause the cannula to emit a second electrical field.