公开(公告)号：US08999242B2

公开(公告)日：2015-04-07

申请号：US14092228

申请日：2013-11-27

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Sridhar G. Iyengar ,  Ha Nguyen ,  Richard Williams ,  Anoop Rao

IPC: G01N33/49 ,  G01N27/26 ,  G01N33/86

CPC classification number: G01N27/26 ,  G01N33/4905 ,  G01N33/86

Abstract: A device for measuring blood coagulation time is formed from a first substrate; a second substrate; a spacer layer disposed between the first and second substrates, said spacer layer having an opening formed therein defining a sample receiving chamber, a vented sink chamber, and an elongated reservoir forming a conduit for liquid movement between the sample receiving chamber and the sink chamber; a first electrode disposed on the first substrate, said first electrode being exposed in the reservoir portion through a first opening in the spacer layer; and a second electrode disposed on the second substrate, said second electrode being exposed in the reservoir portion through a second opening in the spacer layer. The device of the invention is used in combination with an apparatus that is connected to the first and second electrodes for measuring current flow between the first and second electrodes. Changes in observed current are indicative of flow through the device, and a cessation of flow indicates coagulation.

Abstract translation: 用于测量凝血时间的装置由第一基底形成; 第二基板; 间隔层，其设置在所述第一和第二基板之间，所述间隔层具有形成在其中的开口，所述隔离件限定了样品接收室，通气的宿室和形成用于液体在样品接收室和宿室之间移动的导管的细长储存器; 设置在所述第一基板上的第一电极，所述第一电极通过所述间隔层中的第一开口暴露在所述储存部分中; 以及设置在所述第二基板上的第二电极，所述第二电极通过所述间隔层中的第二开口暴露在所述储存部分中。 本发明的装置与连接到第一和第二电极的装置组合使用，用于测量第一和第二电极之间的电流。 观察到的电流的变化表示通过该装置的流动，并且停止流动表示凝结。

公开(公告)号：US20140116894A1

公开(公告)日：2014-05-01

申请号：US14092228

申请日：2013-11-27

Applicant: AgaMatrix, Inc.

Inventor： Ian Harding ,  Sridhar G. Iyengar ,  Ha Nguyen ,  Richard Williams ,  Anoop Rao

IPC: G01N27/26

CPC classification number: G01N27/26 ,  G01N33/4905 ,  G01N33/86

Abstract: A device for measuring blood coagulation time is formed from a first substrate; a second substrate; a spacer layer disposed between the first and second substrates, said spacer layer having an opening formed therein defining a sample receiving chamber, a vented sink chamber, and an elongated reservoir forming a conduit for liquid movement between the sample receiving chamber and the sink chamber; a first electrode disposed on the first substrate, said first electrode being exposed in the reservoir portion through a first opening in the spacer layer; and a second electrode disposed on the second substrate, said second electrode being exposed in the reservoir portion through a second opening in the spacer layer. The device of the invention is used in combination with an apparatus that is connected to the first and second electrodes for measuring current flow between the first and second electrodes. Changes in observed current are indicative of flow through the device, and a cessation of flow indicates coagulation.