公开(公告)号：US12247028B2

公开(公告)日：2025-03-11

申请号：US18524807

申请日：2023-11-30

Applicant: Alcon Inc.

Inventor： David Ellis ,  Howard Allen Ketelson

IPC: A61P27/10 ,  A61K9/00 ,  C07D243/38 ,  C07D471/04 ,  C07D471/08

Abstract: The present invention provides in one aspect azabicyclo and diazepine derivatives useful as modulators of muscarinic receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator.

公开(公告)号：US20220267328A1

公开(公告)日：2022-08-25

申请号：US17699606

申请日：2022-03-21

Applicant: Alcon Inc.

Inventor： David Ellis ,  Howard Allen Ketelson

IPC: C07D471/08 ,  A61P27/10 ,  A61K9/00 ,  C07D243/38 ,  C07D471/04

Abstract: The present invention provides in one aspect azabicyclo and diazepine derivatives useful as modulators of muscarinic receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator.

公开(公告)号：US11306090B2

公开(公告)日：2022-04-19

申请号：US16760192

申请日：2018-11-02

Applicant: Alcon Inc.

Inventor： David Ellis ,  Howard Allen Ketelson

IPC: C07D471/08 ,  A61P27/10 ,  A61K9/00 ,  C07D243/38 ,  C07D471/04

Abstract: The present invention provides in one aspect azabicyclo and diazepine derivatives useful as modulators of muscarinic receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator.

公开(公告)号：US11884666B2

公开(公告)日：2024-01-30

申请号：US17699606

申请日：2022-03-21

Applicant: Alcon Inc.

Inventor： David Ellis ,  Howard Allen Ketelson

IPC: C07D471/08 ,  A61P27/10 ,  A61K9/00 ,  C07D243/38 ,  C07D471/04

CPC classification number: C07D471/08 ,  A61K9/0048 ,  A61P27/10 ,  C07D243/38 ,  C07D471/04

Abstract: The present invention provides in one aspect azabicyclo and diazepine derivatives useful as modulators of muscarinic receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator.

公开(公告)号：US20210179616A1

公开(公告)日：2021-06-17

申请号：US16760192

申请日：2018-11-02

Applicant: Alcon Inc.

Inventor： David Ellis ,  Howard Allen Ketelson

IPC: C07D471/08 ,  C07D471/04 ,  C07D243/38 ,  A61K9/00 ,  A61P27/10

Abstract: The present invention provides in one aspect azabicyclo and diazepine derivatives useful as modulators of muscarinic receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator.

公开(公告)号：US20240132497A1

公开(公告)日：2024-04-25

申请号：US18524807

申请日：2023-11-30

Applicant: Alcon Inc.

Inventor： David Ellis ,  Howard Allen Ketelson

IPC: C07D471/08 ,  A61K9/00 ,  A61P27/10 ,  C07D243/38 ,  C07D471/04

CPC classification number: C07D471/08 ,  A61K9/0048 ,  A61P27/10 ,  C07D243/38 ,  C07D471/04

Abstract: The present invention provides in one aspect azabicyclo and diazepine derivatives useful as modulators of muscarinic receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator.