公开(公告)号：US20200340926A1

公开(公告)日：2020-10-29

申请号：US16859537

申请日：2020-04-27

Applicant: Animated Dynamics, Inc.

Inventor： Ran An ,  Gayatri Narayanan ,  Travis A. Morgan ,  Ted Schenberg

IPC: G01N21/84 ,  G01N21/47 ,  G01N21/55 ,  G01N33/50

Abstract: An interferometric method and apparatus for the non-invasive assessment of oocyte maturity and competency. The method includes placing an oocyte in a sample holder to provide a biological target; generating a near infrared light; using a beam splitter to split the near infrared light into a signal light portion and a reference light portion; projecting the signal light portion onto the biological target; collecting reflected and back scattered light from the signal light portion projected onto the biological target with a detector; collecting at least a portion of the reference light portion with the detector; generating interferometric image data based upon the collected signal and reference light; and assessing the maturity of the oocyte based upon the interferometric data while maintaining the viability of the oocyte. When the oocyte is part of a cumulus-oocyte complex, the assessment is accomplished without removing cumulus cells from the cumulus-oocyte complex while maintaining viability.

公开(公告)号：US11644424B2

公开(公告)日：2023-05-09

申请号：US16859537

申请日：2020-04-27

Applicant: Animated Dynamics, Inc.

Inventor： Ran An ,  Gayatri Narayanan ,  Travis A. Morgan ,  Theodore R. Schenberg

IPC: G01N21/84 ,  G01N21/47 ,  G01N33/50 ,  G01N21/55

CPC classification number: G01N21/84 ,  G01N21/47 ,  G01N21/55 ,  G01N33/5005 ,  G01N2201/062 ,  G01N2201/08

Abstract: An interferometric method and apparatus for the non-invasive assessment of oocyte maturity and competency. The method includes placing an oocyte in a sample holder to provide a biological target; generating a near infrared light; using a beam splitter to split the near infrared light into a signal light portion and a reference light portion; projecting the signal light portion onto the biological target; collecting reflected and back scattered light from the signal light portion projected onto the biological target with a detector; collecting at least a portion of the reference light portion with the detector; generating interferometric image data based upon the collected signal and reference light; and assessing the maturity of the oocyte based upon the interferometric data while maintaining the viability of the oocyte. When the oocyte is part of a cumulus-oocyte complex, the assessment is accomplished without removing cumulus cells from the cumulus-oocyte complex while maintaining viability.