公开(公告)号：US12005145B2

公开(公告)日：2024-06-11

申请号：US17695687

申请日：2022-03-15

Applicant: Applied Materials, Inc.

Inventor： Colin C. Neikirk ,  Jonathan Frankel

IPC: A61K9/50 ,  A61J3/07 ,  A61K31/405 ,  A61K31/424 ,  A61K31/43 ,  A61K31/506 ,  A61K31/519 ,  A61K31/7048 ,  A61K47/58 ,  C07K16/22 ,  C07K16/28 ,  C07K16/32 ,  C23C16/40 ,  C23C16/44 ,  C23C16/455 ,  C23C16/458

CPC classification number: A61K9/5089 ,  A61J3/07 ,  A61K9/501 ,  A61K31/405 ,  A61K31/424 ,  A61K31/43 ,  A61K31/506 ,  A61K31/519 ,  A61K31/7048 ,  A61K47/58 ,  C07K16/22 ,  C07K16/2833 ,  C07K16/32 ,  C23C16/40 ,  C23C16/403 ,  C23C16/405 ,  C23C16/4417 ,  C23C16/45525 ,  C23C16/45555 ,  C23C16/458 ,  C07K2317/24 ,  C07K2317/94 ,  A61K31/424 ,  A61K2300/00 ,  A61K31/43 ,  A61K2300/00

Abstract: A method of preparing a pharmaceutical composition having a drug-containing core enclosed by one or more metal oxide materials is provided. The method includes the sequential steps of (a) loading the particles comprising the drug into a reactor, (b) applying a vaporous or gaseous metal precursor to the particles in the reactor, (c) performing one or more pump-purge cycles of the reactor using inert gas, (d) applying a vaporous or gaseous oxidant to the particles in the reactor, and (e) performing one or more pump-purge cycles of the reactor using inert gas. The temperature of the particles does not exceed 35° C. This produces a pharmaceutical composition comprising a drug containing core enclosed by one or more metal oxide materials.

公开(公告)号：US20230347310A1

公开(公告)日：2023-11-02

申请号：US18212599

申请日：2023-06-21

Applicant: Applied Materials, Inc.

Inventor： Jonathan Frankel ,  Colin C. Neikirk ,  Pravin K. Narwankar ,  Quoc Truong ,  Govindraj Desai ,  Sekar Krishnasamy

IPC: B01J8/10 ,  C23C16/44 ,  B05D1/00 ,  B01F27/70 ,  B01F27/112

CPC classification number: B01J8/10 ,  C23C16/4417 ,  B05D1/60 ,  B01F27/70 ,  B01F27/112 ,  B01J2208/00867 ,  B01F2101/22

Abstract: A reactor for coating particles includes a stationary vacuum chamber to hold a bed of particles to be coated, a vacuum port in an upper portion of the chamber, a chemical delivery system configured to inject a reactant or precursor gas into a lower portion of the chamber, a paddle assembly, and a motor to rotate a drive shaft of the paddle assembly. The lower portion of the chamber forms a half-cylinder. The paddle assembly includes a rotatable drive shaft extending through the chamber along the axial axis of the half cylinder, and a plurality of paddles extending radially from the drive shaft such that rotation of the drive shaft by the motor orbits the plurality of paddles about the drive shaft.

公开(公告)号：US20220296530A1

公开(公告)日：2022-09-22

申请号：US17636293

申请日：2020-08-27

Applicant: Applied Materials, Inc.

Inventor： Colin C. Neikirk

IPC: A61K9/50 ,  C23C16/455 ,  C23C16/44

Abstract: A method of preparing a pharmaceutical composition having a drug-containing core enclosed by one or more metal oxide materials is provided. The method includes the sequential steps of (a) loading the particles comprising the drug into a reactor, (b) applying a vaporous or gaseous metal precursor to the particles in the reactor, (c) performing one or more pump-purge cycles of the reactor using inert gas, (d) applying a vaporous or gaseous oxidant to the particles in the reactor, and (e) performing one or more pump-purge cycles of the reactor using inert gas. The temperature of the particles does not exceed 35° C. This produces a pharmaceutical composition comprising a drug containing core enclosed by one or more metal oxide materials.

公开(公告)号：US20200338521A1

公开(公告)日：2020-10-29

申请号：US16855871

申请日：2020-04-22

Applicant: Applied Materials, Inc.

Inventor： Jonathan Frankel ,  Colin C. Neikirk ,  Pravin K. Narwankar ,  Quoc Truong ,  Govindraj Desai ,  Sekar Krishnasamy

IPC: B01J19/18 ,  B01F7/00 ,  B01F7/04 ,  B01J19/00

Abstract: A reactor for coating particles includes a stationary vacuum chamber having a lower portion that forms a half-cylinder and an upper portion to hold a bed of particles to be coated, a vacuum port in the upper portion of the chamber, a paddle assembly, a motor to rotate a drive shaft of the paddle assembly, a chemical delivery system to deliver a first fluid, and a first gas injection assembly to receive the first fluid from the chemical delivery system and having apertures configured to inject a first reactant or precursor gas into the lower portion of the chamber and such that the first reactant or precursor gas flows substantially tangent to a curved inner surface of the half-cylinder.

公开(公告)号：US20200338008A1

公开(公告)日：2020-10-29

申请号：US16858439

申请日：2020-04-24

Applicant: Applied Materials, Inc.

Inventor： Fei Wang ,  Colin C. Neikirk ,  Jonathan Frankel ,  Pravin K. Narwankar

IPC: A61K9/16

Abstract: A method of preparing a pharmaceutical composition having a drug-containing core enclosed by one or more metal oxide materials is provided. The method includes the sequential atomic layer deposition of a metal oxide layer(s) followed by molecular level deposition of a polymer layer(s). This produces a pharmaceutical composition comprising a drug containing core enclosed by one or more metal oxide materials and one more polymer materials

公开(公告)号：US20190216742A1

公开(公告)日：2019-07-18

申请号：US16249885

申请日：2019-01-16

Applicant: Applied Materials, Inc.

Inventor： Colin C. Neikirk ,  Jonathan Frankel

IPC: A61K9/50 ,  A61K31/7048 ,  A61K47/58 ,  A61K31/506 ,  A61K31/519 ,  A61K31/43 ,  A61K31/405 ,  C07K16/32 ,  C07K16/22 ,  C07K16/28 ,  A61J3/07 ,  C23C16/40 ,  C23C16/455

CPC classification number: A61K9/5089 ,  A61J3/07 ,  A61K9/501 ,  A61K31/405 ,  A61K31/43 ,  A61K31/506 ,  A61K31/519 ,  A61K31/7048 ,  A61K47/58 ,  C07K16/22 ,  C07K16/2833 ,  C07K16/32 ,  C07K2317/24 ,  C23C16/40 ,  C23C16/45525

Abstract: A method of preparing a pharmaceutical composition having a drug-containing core enclosed by one or more metal oxide materials is provided. The method includes the sequential steps of (a) loading the particles comprising the drug into a reactor, (b) applying a vaporous or gaseous metal precursor to the particles in the reactor, (c) performing one or more pump-purge cycles of the reactor using inert gas, (d) applying a vaporous or gaseous oxidant to the particles in the reactor, and (e) performing one or more pump-purge cycles of the reactor using inert gas. The temperature of the particles does not exceed 35° C. This produces a pharmaceutical composition comprising a drug containing core enclosed by one or more metal oxide materials.

公开(公告)号：US12134091B2

公开(公告)日：2024-11-05

申请号：US18212599

申请日：2023-06-21

Applicant: Applied Materials, Inc.

Inventor： Jonathan Frankel ,  Colin C. Neikirk ,  Pravin K. Narwankar ,  Quoc Truong ,  Govindraj Desai ,  Sekar Krishnasamy

IPC: C23C16/44 ,  B01F27/112 ,  B01F27/70 ,  B01J8/10 ,  B05D1/00 ,  B01F101/22

Abstract: A reactor for coating particles includes a stationary vacuum chamber to hold a bed of particles to be coated, a vacuum port in an upper portion of the chamber, a chemical delivery system configured to inject a reactant or precursor gas into a lower portion of the chamber, a paddle assembly, and a motor to rotate a drive shaft of the paddle assembly. The lower portion of the chamber forms a half-cylinder. The paddle assembly includes a rotatable drive shaft extending through the chamber along the axial axis of the half cylinder, and a plurality of paddles extending radially from the drive shaft such that rotation of the drive shaft by the motor orbits the plurality of paddles about the drive shaft.

公开(公告)号：US11717800B2

公开(公告)日：2023-08-08

申请号：US16855860

申请日：2020-04-22

Applicant: Applied Materials, Inc.

Inventor： Jonathan Frankel ,  Colin C. Neikirk ,  Pravin K. Narwankar ,  Quoc Truong ,  Govindraj Desai ,  Sekar Krishnasamy

IPC: B01J8/10 ,  C23C16/44 ,  B05D1/00 ,  B01F27/70 ,  B01F27/112 ,  B01F101/22

CPC classification number: B01J8/10 ,  B01F27/112 ,  B01F27/70 ,  B05D1/60 ,  C23C16/4417 ,  B01F2101/22 ,  B01J2208/00867

Abstract: A reactor for coating particles includes a stationary vacuum chamber to hold a bed of particles to be coated, a vacuum port in an upper portion of the chamber, a chemical delivery system configured to inject a reactant or precursor gas into a lower portion of the chamber, a paddle assembly, and a motor to rotate a drive shaft of the paddle assembly. The lower portion of the chamber forms a half-cylinder. The paddle assembly includes a rotatable drive shaft extending through the chamber along the axial axis of the half cylinder, and a plurality of paddles extending radially from the drive shaft such that rotation of the drive shaft by the motor orbits the plurality of paddles about the drive shaft.

公开(公告)号：US11311491B2

公开(公告)日：2022-04-26

申请号：US16249885

申请日：2019-01-16

Applicant: Applied Materials, Inc.

Inventor： Colin C. Neikirk ,  Jonathan Frankel

IPC: A61K9/50 ,  A61K47/58 ,  A61K31/506 ,  A61K31/519 ,  A61K31/43 ,  A61K31/405 ,  C07K16/32 ,  C07K16/22 ,  C07K16/28 ,  A61J3/07 ,  C23C16/40 ,  C23C16/455 ,  A61K31/7048 ,  A61K31/424 ,  C23C16/44 ,  C23C16/458

Abstract: A method of preparing a pharmaceutical composition having a drug-containing core enclosed by one or more metal oxide materials is provided. The method includes the sequential steps of (a) loading the particles comprising the drug into a reactor, (b) applying a vaporous or gaseous metal precursor to the particles in the reactor, (c) performing one or more pump-purge cycles of the reactor using inert gas, (d) applying a vaporous or gaseous oxidant to the particles in the reactor, and (e) performing one or more pump-purge cycles of the reactor using inert gas. The temperature of the particles does not exceed 35° C. This produces a pharmaceutical composition comprising a drug containing core enclosed by one or more metal oxide materials.

公开(公告)号：US11242599B2

公开(公告)日：2022-02-08

申请号：US16515875

申请日：2019-07-18

Applicant: Applied Materials, Inc.

Inventor： Kaushal Gangakhedkar ,  Jonathan Frankel ,  Colin C. Neikirk ,  Pravin K. Narwankar

IPC: C23C16/44 ,  C23C16/455 ,  A61K9/16

Abstract: A reactor for coating particles includes a vacuum chamber configured to hold particles to be coated, a vacuum port to exhaust gas from the vacuum chamber via the outlet of the vacuum chamber, a chemical delivery system configured to flow a process gas into the particles via a gas inlet on the vacuum chamber, one or more vibrational actuators located on a first mounting surface of the vacuum chamber, and a controller configured to cause the one or more vibrational actuators to generate a vibrational motion in the vacuum chamber sufficient to induce a vibrational motion in the particles held within the vacuum chamber.