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    NANO-RECOMBINANT FIBRINOGEN FOR FIBRIN SEALANTS
    2.
    发明申请
    NANO-RECOMBINANT FIBRINOGEN FOR FIBRIN SEALANTS 审中-公开
    用于FIBRIN SEALANTS的纳米重组纤维蛋白原

    公开(公告)号：US20150157694A1

    公开(公告)日：2015-06-11

    申请号：US14551332

    申请日：2014-11-24

    Applicant: BAE Systems Information and Electronic Systems Integration Inc.

    Inventor： Robert A. Burton

    IPC: A61K38/36

    CPC classification number: A61K38/363 ,  A61K47/6923 ,  A61K47/6935 ,  C07K14/75 ,  C12Q1/56

    Abstract: A fibrin-based hemostatic agent suitable for both civilian and military use is disclosed. The hemostatic agent comprises (i) nanoparticles to which a plurality of Knob-A recognition sequences are attached, and (ii) coiled-coils of recombinantly-produced human fibrinogen α and chains and the γ chain globular domain. A delivery system for the hemostatic agent also is disclosed, which additionally comprises means for delivering (i) and (ii) to a wound site. The delivery means may be a CO2 canister or a shaker jet.

    Abstract translation: 公开了适用于民用和军用的基于纤维蛋白的止血剂。 止血剂包括（i）多个Knob-A识别序列连接的纳米颗粒，和（ii）重组产生的人纤维蛋白原α和链的线圈和γ链球形结构域。 还公开了止血剂的递送系统，其还包括用于将（i）和（ii）递送到伤口部位的装置。 输送装置可以是CO 2罐或振荡器喷嘴。

    CARBIDE-DERIVED-CARBON-BASED OXYGEN CARRIERS
    5.
    发明申请
    CARBIDE-DERIVED-CARBON-BASED OXYGEN CARRIERS 审中-公开
    碳化硅衍生的氧化碳载体

    公开(公告)号：US20140147507A1

    公开(公告)日：2014-05-29

    申请号：US14168609

    申请日：2014-01-30

    Applicant: BAE Systems Information and Electronic Systems Integration Inc.

    Inventor： Robert A. Burton

    IPC: A61K47/02 ,  A61K38/42

    CPC classification number: A61K47/02 ,  A61K38/16 ,  A61K38/42 ,  Y02A50/463

    Abstract: An oxygen delivery system is disclosed. The basis of the oxygen deliver system is a carbide-derived carbon (CDC). The CDC can be tuned to carry O2 directly (CDC OC), or hemoglobin can be adsorbed to provide a hemoglobin-based oxygen carrier (CDC HBOC). The delivery system allows the use of a variety of hemoglobins which differ in their oxygen dissociation profiles, including variant and mutant hemoglobins from other species. The delivery system is biocompatible and stable, and is able to irreversibly bind and hold large amounts of functional hemoglobin variants. The CDC HBOC and CDC OC provide a safe and effective blood substitute for combat casualty care, as well as being useful for oxygen delivery in other contexts.

    Abstract translation: 公开了一种氧气输送系统。 氧气输送系统的基础是碳化物衍生的碳（CDC）。 可以调整CDC直接携带O2（CDC OC），或者可以吸收血红蛋白以提供基于血红蛋白的氧载体（CDC HBOC）。 递送系统允许使用各种血氧素，其氧解离曲线不同，包括来自其他物种的变体和突变体血红蛋白。 递送系统是生物相容性和稳定性的，并且能够不可逆地结合和保持大量的功能性血红蛋白变体。 CDC HBOC和CDC OC为战斗伤员护理提供安全有效的血液替代品，并且在其他情况下可用于氧气输送。

    Nano-recombinant fibrinogen for fibrin sealants
    7.
    发明授权
    Nano-recombinant fibrinogen for fibrin sealants 有权
    用于纤维蛋白封闭剂的纳米重组纤维蛋白原

    公开(公告)号：US09381232B2

    公开(公告)日：2016-07-05

    申请号：US14551332

    申请日：2014-11-24

    Applicant: BAE Systems Information and Electronic Systems Integration Inc.

    Inventor： Robert A. Burton

    IPC: A61K38/36 ,  C07K14/75 ,  C12Q1/56 ,  A61K47/48

    CPC classification number: A61K38/363 ,  A61K47/6923 ,  A61K47/6935 ,  C07K14/75 ,  C12Q1/56

    Abstract: A fibrin-based hemostatic agent suitable for both civilian and military use is disclosed. The hemostatic agent comprises (i) nanoparticles to which a plurality of Knob-A recognition sequences are attached, and (ii) coiled-coils of recombinantly-produced human fibrinogen α and chains and the γ chain globular domain. A delivery system for the hemostatic agent also is disclosed, which additionally comprises means for delivering (i) and (ii) to a wound site. The delivery means may be a CO2 canister or a shaker jet.

    Abstract translation: 公开了适用于民用和军用的基于纤维蛋白的止血剂。 止血剂包括（i）附着有多个Knob-A识别序列的纳米颗粒，和（ii）重组产生的人纤维蛋白原α和链的线圈和γ链球形结构域。 还公开了止血剂的递送系统，其还包括用于将（i）和（ii）递送到伤口部位的装置。 输送装置可以是CO 2罐或振荡器喷嘴。

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