公开(公告)号：US20190113514A1

公开(公告)日：2019-04-18

申请号：US16162261

申请日：2018-10-16

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jing Yong Ye ,  Jonathan D. Scudder

IPC: G01N33/579 ,  G01N21/31

Abstract: A pyrogenicity test assay and method of pyrogen testing that allows for rapid and ultrahigh sensitivity testing of parenteral pharmaceuticals or medical devices that contact blood or cerebrospinal fluid by employing a Limulus Amoebocyte Lysate (LAL) assay utilizing a photonic-crystal biosensor. The photonic-crystal biosensor is capable of determining the presence of endotoxins in a test sample by monitoring shifts in the resonant wavelength of an open microcavity affected by the changes in the refractive index of the analyte solutions used.

公开(公告)号：US11892397B2

公开(公告)日：2024-02-06

申请号：US17316467

申请日：2021-05-10

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jing Yong Ye ,  Jonathan D. Scudder

IPC: G01N21/31

CPC classification number: G01N21/31 ,  G01N2201/0633 ,  G01N2201/0636 ,  G01N2201/0638 ,  G01N2201/06113 ,  G01N2201/08

Abstract: A pyrogenicity test method and assay of endotoxins allows for rapid and ultrahigh sensitivity testing of parenteral pharmaceuticals or medical devices that contact blood or cerebrospinal fluid by employing a Limulus Amoebocyte Lysate (LAL) assay monitored with a photonic-crystal biosensor. The photonic-crystal biosensor is capable of determining the presence of endotoxins in a test sample by detecting shifts in the resonant condition of an open microcavity affected by the changes in the refractive index of the analyte solutions used.

公开(公告)号：US20210262924A1

公开(公告)日：2021-08-26

申请号：US17316467

申请日：2021-05-10

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jing Yong Ye ,  Jonathan D. Scudder

IPC: G01N21/31

Abstract: A pyrogenicity test method and assay of endotoxins allows for rapid and ultrahigh sensitivity testing of parenteral pharmaceuticals or medical devices that contact blood or cerebrospinal fluid by employing a Limulus Amoebocyte Lysate (LAL) assay monitored with a photonic-crystal biosensor. The photonic-crystal biosensor is capable of determining the presence of endotoxins in a test sample by detecting shifts in the resonant condition of an open microcavity affected by the changes in the refractive index of the analyte solutions used.

公开(公告)号：US11099189B2

公开(公告)日：2021-08-24

申请号：US16162261

申请日：2018-10-16

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jing Yong Ye ,  Jonathan D. Scudder

IPC: G01N33/579 ,  G01N21/31 ,  G01N21/77 ,  G01N21/43

Abstract: A pyrogenicity test assay and method of pyrogen testing that allows for rapid and ultrahigh sensitivity testing of parenteral pharmaceuticals or medical devices that contact blood or cerebrospinal fluid by employing a Limulus Amoebocyte Lysate (LAL) assay utilizing a photonic-crystal biosensor. The photonic-crystal biosensor is capable of determining the presence of endotoxins in a test sample by monitoring shifts in the resonant wavelength of an open microcavity affected by the changes in the refractive index of the analyte solutions used.