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公开(公告)号：US20220306630A1
公开(公告)日：2022-09-29
申请号：US17632909
申请日：2020-08-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lalgudi S. Harikrishnan , Peter Kinam Park , Zheming Ruan , Donna D. Wei , Daniel O'Malley , Honghe Wan , Ashok Vinayak Purandare , Brian E. Fink
IPC: C07D471/10 , C07C317/18 , C07D213/73 , C07D213/71 , C07C255/60 , C07D213/82 , C07D231/12 , C07D231/18 , C07D263/24 , C07D213/56 , C07D401/12 , C07C311/16 , C07D213/69 , C07D233/61 , C07D211/34 , C07D235/18 , C07D213/58 , C07D211/96 , C07D295/26
Abstract: The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US11427610B2
公开(公告)日：2022-08-30
申请号：US16849091
申请日：2018-10-16
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Brian E. Fink , Yufen Zhao , Libing Chen , Audris Huang
Abstract: The present invention is directed to compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US10519187B2
公开(公告)日：2019-12-31
申请号：US16272172
申请日：2019-02-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Brian E. Fink , Dharmpal S. Dodd , Steven J. Walker , Libing Chen , Yufen Zhao , Zheming Ruan , Lan-Ying Qin , Peter Kinam Park , Muthoni G. Kamau , Lalgudi S. Harikrishnan
IPC: C07H19/213 , A61P35/00 , C07K16/28
Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US10399987B2
公开(公告)日：2019-09-03
申请号：US15747843
申请日：2016-07-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lalgudi S. Harikrishnan , Brian E. Fink , Robert M. Borzilleri , Gopikishan Tonukunuru , Jayakumar Sankara Warrier
IPC: C07D487/04 , A61P35/00 , A61K31/519
Abstract: The invention relates generally to compounds that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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公开(公告)号：US20180243312A1
公开(公告)日：2018-08-30
申请号：US15755636
申请日：2016-08-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Robert M. BORZILLERI , Brian E. Fink , Lalgudi S. Harikrishnan , Jayakumar Sankara Warrier
CPC classification number: A61K31/53 , A61K35/02 , A61K2121/00 , A61P35/00 , C07D487/04 , C07D519/00
Abstract: The invention relates generally to compounds that modulate the activity of TGFBETA R-1 and TGFBETA R-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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Patent Agency Ranking
公开(公告)号：US20160108050A1
公开(公告)日：2016-04-21
申请号：US14976476
申请日：2015-12-21
Applicant: Bristol-Myers Squibb Company
Inventor： Ashok Vinayak Purandare , Brian E. Fink , Walter Lewis Johnson , Amy C. Hart , Liqi He , Tram N. Huynh , Jennifer lnghrim , Harold Mastalerz , Xiaopeng Sang , Christine M. Tarby , Honghe Wan , Wayne Vaccaro , Guifen Zhang , Yufen Zhao , Kurt Zimmermann , Yong Zhang , Libing Chen , Bin Chen , John S. Tokarski , Ashvinikumar V. Gavai
IPC: C07D487/04 , C07F9/6561 , C07F7/18 , C07D519/00
CPC classification number: C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/6521 , C07F9/6561 , C07F9/65616
Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.
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公开(公告)号：US09273075B2
公开(公告)日：2016-03-01
申请号：US14429930
申请日：2013-09-20
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ashvinikumar V. Gavai , Wen-Ching Han , Brian E. Fink , Victor R. Guarino
IPC: C07D243/18 , C07D243/26 , C07F9/645 , A61K31/675 , C07D243/24 , A61K31/5513 , C07D401/12 , A61K45/06
CPC classification number: C07F9/645 , A61K31/5513 , A61K31/675 , A61K45/06 , C07D243/18 , C07D243/24 , C07D243/26 , C07D401/12 , C07F9/12 , A61K2300/00
Abstract: Disclosed are compounds of Formula (I) and salts thereof, wherein: a) R1 is H or CH3, and R2 is Ry; or b) R1 is Rx and R2 is H; wherein Rx and Ry are disclosed herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are prodrugs of compounds that are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.
Abstract translation: 公开了式（I）的化合物及其盐，其中：a）R1是H或CH3，R2是Ry; 或b）R1是Rx，R2是H; 其中Rx和Ry在本文中公开。 还公开了使用这些化合物抑制Notch受体的方法，以及包含这些化合物的药物组合物。 这些化合物是可用于治疗，预防或减缓各种治疗领域（例如癌症）中疾病或病症进展的化合物的前药。
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公开(公告)号：US12012374B2
公开(公告)日：2024-06-18
申请号：US17610548
申请日：2020-05-07
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lalgudi S. Harikrishnan , Muthoni G. Kamau , Brian E. Fink
IPC: C07D207/12 , C07C317/22 , C07D401/06 , C07D403/06 , C07D407/06 , C07D409/06 , C07D417/06
CPC classification number: C07C317/22 , C07D207/12 , C07D401/06 , C07D403/06 , C07D407/06 , C07D409/06 , C07D417/06
Abstract: The present invention is directed to compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US11945834B2
公开(公告)日：2024-04-02
申请号：US16978208
申请日：2019-03-07
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Brian E. Fink , Zheming Ruan
CPC classification number: C07H21/02 , C07K16/2818
Abstract: The present invention is directed to compounds of formulae (I) and (II) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US11660311B2
公开(公告)日：2023-05-30
申请号：US16754301
申请日：2018-10-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Brian E. Fink , Dharmpal S. Dodd , Yufen Zhao , Lan-Ying Qin , Zheming Ruan , Lalgudi S. Harikrishnan , Muthoni G. Kamau
IPC: C07H21/04 , A61K31/7084 , A61K39/395
CPC classification number: A61K31/7084 , A61K39/3955 , C07H21/04
Abstract: The present invention is directed to compounds of the formula (I), wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
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