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公开(公告)号：US11242393B2
公开(公告)日：2022-02-08
申请号：US16362411
申请日：2019-03-22
Applicant: Bristol-Myers Squibb Company
Inventor： Michelle Renee Kuhne , Alan J. Korman , Haichun Huang , Yiming Yin , Robert F. Graziano , Natalie A. Bezman , Pavel Strop , Richard Y. Huang , Guodong Chen , Mohan Srinivasan , Peter Sung Keun Lee , Gamze Ozlem Camdere
Abstract: The disclosure provides antibodies that specifically bind human MICA/B and methods of use thereof. In some aspects, the disclosure is directed to methods of treating a cancer in a subject, comprising administering to the subject an anti-MICA/B antibody.
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公开(公告)号：US11213586B2
公开(公告)日：2022-01-04
申请号：US15776591
申请日：2016-11-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Changyu Wang , Nils Lonberg , Alan J. Korman , Mark J. Selby , Mohan Srinivasan , Karla A. Henning , Michelle Minhua Han , Guodong Chen , Richard Y. Huang , Indrani Chakraborty , Haichun Huang , Susan Chien-Szu Wong , Huiming Li , Bryan C. Barnhart , Aaron P. Yamniuk , Ming Lei , Liang Schweizer , Sandra V. Hatcher , Arvind Rajpal
IPC: C07K16/28 , A61K39/395 , G01N33/574 , G01N33/68 , A61K39/00
Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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公开(公告)号：US20210155703A1
公开(公告)日：2021-05-27
申请号：US17045143
申请日：2019-04-03
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Li-Sheng Lu , Mark J. Selby , Alan J. Korman , Shrikant Deshpande , Mohan Srinivasan , Jun Zhang , Haichun Huang , Guodong Chen , Richard Y. Huang , Ekaterina G. Deyanova
IPC: C07K16/28 , A61K39/395 , A61P35/00 , A61K45/06
Abstract: This disclosure provides isolated antibodies that bind specifically to CD27 with high affinity. The disclosure provides methods for treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of an anti-CD27 antibody as monotherapy or in combination with a checkpoint inhibitor, such as an anti-PD-1, anti-PD-L1, or anti-CTLA-4 antibody.
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公开(公告)号：US20180057600A1
公开(公告)日：2018-03-01
申请号：US15807351
申请日：2017-11-08
Applicant: Pflzer Inc. , Bristol-Myers Squibb Company
Inventor： Jing MIN , Yanli Wu , Rory F. Finn , Barrett R. Thiele , Wei Liao , Ronald P. Gladue , Arvind Rajpal , Timothy J. Paradis , Peter Brams , Brigitte Devaux , Yi Wu , Kristopher Toy , Heidi N. Leblanc , Haichun Huang
IPC: C07K16/28
CPC classification number: C07K16/2878 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/565 , C07K2317/92
Abstract: The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.
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5.发明申请公开(公告)号：US20180052175A1
公开(公告)日：2018-02-22
申请号：US15601617
申请日：2017-05-22
Applicant: Pfizer Inc. , Bristol-Myers Squibb Company
Inventor： Robert Arch , Jun Zhang , Michelle Mader , Tetsuya Ishino , Joel Bard , William Finlay , Orla Cunningham , Ciara Reilly , Peter Brams , Brigitte Devaux , Haichun Huang , Karla Henning
CPC classification number: G01N33/6863 , C07K16/2875 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92
Abstract: The present invention provides antibodies, or antigen-binding fragment thereof, which specifically bind to TL1A. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of TL1A mediated diseases, disorders or conditions.
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Patent Agency Ranking
6.发明授权公开(公告)号：US09745379B2
公开(公告)日：2017-08-29
申请号：US14949424
申请日：2015-11-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Changyu Wang , Nils Lonberg , Alan J. Korman , Mark J. Selby , Mohan Srinivasan , Karla Henning , Michelle Minhua Han , Guodong Chen , Richard Huang , Indrani Chakraborty , Haichun Huang , Susan Wong , Huiming Li
IPC: C07K16/00 , C07H21/00 , C07K16/28 , A61K39/395 , G01N33/68 , G01N33/574 , A61K39/00
CPC classification number: C07K16/2878 , A61K39/3955 , A61K47/48569 , A61K47/6851 , A61K2039/505 , A61K2039/507 , C07K16/2818 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N33/6872 , G01N2333/70578
Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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7.发明授权Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof 有权抗糖皮质激素诱导的肿瘤坏死因子受体（GITR）的抗体及其用途公开(公告)号：US09228016B2
公开(公告)日：2016-01-05
申请号：US14732082
申请日：2015-06-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Changyu Wang , Nils Lonberg , Alan J. Korman , Mark J. Selby , Mohan Srinivasan , Karla Henning , Michelle Minhua Han , Guodong Chen , Richard Huang , Indrani Chakraborty , Haichun Huang , Susan Wong , Huiming Li
IPC: C07K16/00 , C07H21/00 , C07K16/28 , A61K39/395 , G01N33/68 , G01N33/574 , A61K39/00
CPC classification number: C07K16/2878 , A61K39/3955 , A61K47/48569 , A61K47/6851 , A61K2039/505 , A61K2039/507 , C07K16/2818 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N33/6872 , G01N2333/70578
Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
Abstract translation: 本文提供了结合糖皮质激素诱导型TNF受体（GITR）的抗体或其抗原结合部分。 还提供了这些蛋白质在治疗应用中的用途，例如在癌症的治疗中。 还提供了产生抗体的细胞，编码抗体的重链和/或轻链可变区的多核苷酸，以及包含编码抗体的重链和/或轻链可变区的多核苷酸的载体。
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公开(公告)号：US20150218279A1
公开(公告)日：2015-08-06
申请号：US14692948
申请日：2015-04-22
Applicant: Pfizer Inc. , Bristol-Myers Squibb Company
Inventor： Jing Min , Yanli Wu , Rory F. Finn , Barrett R. Thiele , Wei Liao , Ronald P. Gladue , Arvind Rajpal , Timothy J. Paradis , Peter Brams , Brigitte Devaux , Yi Wu , Kristopher Toy , Heidi N. LeBlanc , Haichun Huang
IPC: C07K16/28
CPC classification number: C07K16/2878 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/565 , C07K2317/92
Abstract: The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.
Abstract translation: 本公开提供了结合人OX40R的分离的结合分子，编码结合分子的氨基酸序列的核酸分子，包含核酸分子的载体，含有载体的宿主细胞，制备结合分子的方法，含有 结合分子，以及使用结合分子或组合物的方法。
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公开(公告)号：US08846037B2
公开(公告)日：2014-09-30
申请号：US13857867
申请日：2013-04-05
Applicant: Pfizer Inc. , Bristol-Myers Squibb Company
Inventor： Arvind Rajpal , Madhav Narasimha Devalaraja , Kristopher Toy , Lan Yang , Haichun Huang , Jun Zhang , Peter Brams , Brigitte Devaux , David B. Passmore
IPC: A61K39/395 , A61K39/00 , C07K16/24
CPC classification number: C07K16/248 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92
Abstract: Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions.
Abstract translation: 提供了结合人IL-6的抗体及其抗原结合部分。 还提供了编码此类抗体和抗原结合部分的核酸，制备此类抗体和抗原结合部分的方法，包含此类抗体或抗原结合部分的组合物，以及此类抗体或抗原结合部分的用途。
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公开(公告)号：US11408889B2
公开(公告)日：2022-08-09
申请号：US16870006
申请日：2020-05-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Xi-Tao Wang , Olufemi A. Adelakun , Anne C. Lewin , Alan J. Korman , Mark J. Selby , Changyu Wang , Haichun Huang , Karla A. Henning , Nils Lonberg , Mohan Srinivasan , Michelle Minhua Han , Guodong Chen , Richard Y. Huang , Indrani Chakraborty , Susan Chien-Szu Wong , Huiming Li
IPC: G01N33/566 , G01N33/574 , C07K16/28
Abstract: Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.
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