公开(公告)号：US12084426B2

公开(公告)日：2024-09-10

申请号：US17274227

申请日：2019-09-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Junqing Guo ,  Carolyn Diane Dzierba ,  Amy C. Hart ,  John E. Macor ,  William J. Pitts

IPC: C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D413/04 ,  C07D413/14

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D413/04 ,  C07D413/14

Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

公开(公告)号：US11767322B2

公开(公告)日：2023-09-26

申请号：US17503516

申请日：2021-10-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Guanglin Luo ,  Jie Chen ,  Carolyn Diane Dzierba ,  David B. Frennesson ,  Junqing Guo ,  Amy C. Hart ,  Xirui Hu ,  Michael C. Mertzman ,  Matthew Reiser Patton ,  Jianliang Shi ,  Steven H. Spergel ,  Brian Lee Venables ,  Yong-Jin Wu ,  Zili Xiao ,  Michael G. Yang

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof,




are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

公开(公告)号：US20220315580A1

公开(公告)日：2022-10-06

申请号：US17116016

申请日：2020-12-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Junqing Guo ,  Amy C. Hart ,  John E. Macor ,  Michael E. Mertzman ,  William J. Pitts ,  Steven H. Spergel ,  Scott Hunter Watterson ,  Murugaiah Andappan Murugaiah Subbaiah ,  Jie Chen ,  Carolyn Diane Dzierba ,  Guanglin Luo ,  Jianliang Shi ,  Sing-Yuen Sit

IPC: C07D471/04

Abstract: Compounds having formula (I)-(IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

公开(公告)号：US20200347071A1

公开(公告)日：2020-11-05

申请号：US16963886

申请日：2019-01-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Scott Hunter Watterson ,  Murugaiah Andappan Murugaiah Subbaiah ,  Carolyn Diane Dzierba ,  Hua Gong ,  Jason M. Guernon ,  Junqing Guo ,  Amy C. Hart ,  Guanglin Luo ,  John E. Macor ,  William J. Pitts ,  Jianliang Shi ,  Brian Lee Venables ,  Carolyn A. Weigelt ,  Yong-Jin Wu ,  Zhizhen Barbara Zheng ,  Sing-Yuen Sit ,  Jie Chen

IPC: C07D487/04

Abstract: The disclosure relates to compounds of formula I which are useful as kinase modulators including RIPK 1 modulation. The disclosure also provides methods of making and using the compounds for example in treatments related to necrosis or inflammation as well as other indications.

公开(公告)号：US20240425505A1

公开(公告)日：2024-12-26

申请号：US18817352

申请日：2024-08-28

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Guanglin Luo ,  Jie Chen ,  Carolyn Diane Dzierba ,  David B. Frennesson ,  Junqing Guo ,  Amy C. Hart ,  Xirui Hu ,  Michael E. Mertzman ,  Matthew Reiser Patton ,  Jianliang Shi ,  Steven H. Spergel ,  Brian Lee Venables ,  Yong-Jin Wu ,  Zili Xiao ,  Michael G. Yang

IPC: C07D471/04

Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

公开(公告)号：US12157733B2

公开(公告)日：2024-12-03

申请号：US17116016

申请日：2020-12-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Junqing Guo ,  Amy C. Hart ,  John E. Macor ,  Michael E. Mertzman ,  William J. Pitts ,  Steven H. Spergel ,  Scott Hunter Watterson ,  Murugaiah Andappan Murugaiah Subbaiah ,  Jie Chen ,  Carolyn Diane Dzierba ,  Guanglin Luo ,  Jianliang Shi ,  Sing-Yuen Sit

IPC: C07D471/04

Abstract: Compounds having formula (I)-(IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

公开(公告)号：US11618753B2

公开(公告)日：2023-04-04

申请号：US16963886

申请日：2019-01-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Scott Hunter Watterson ,  Murugaiah Andappan Murugaiah Subbaiah ,  Carolyn Diane Dzierba ,  Hua Gong ,  Jason M. Guernon ,  Junqing Guo ,  Amy C. Hart ,  Guanglin Luo ,  John E. Macor ,  William J. Pitts ,  Jianliang Shi ,  Brian Lee Venables ,  Carolyn A. Weigelt ,  Yong-Jin Wu ,  Zhizhen Barbara Zheng ,  Sing-Yuen Sit ,  Jie Chen

IPC: A61K31/53 ,  C07D253/08 ,  C07D487/04

Abstract: The disclosure relates to compounds of formula I which are useful as kinase modulators including RIPK 1 modulation. The disclosure also provides methods of making and using the compounds for example in treatments related to necrosis or inflammation as well as other indications.

公开(公告)号：US10301306B2

公开(公告)日：2019-05-28

申请号：US15527343

申请日：2015-12-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Amy C. Hart ,  William J. Pitts ,  Harold Mastalerz ,  Junqing Guo ,  Gregory D. Brown

IPC: C07D471/04

Abstract: Compounds having Formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK3 modulation. All the variables defined herein.

公开(公告)号：US12275721B2

公开(公告)日：2025-04-15

申请号：US17762771

申请日：2020-10-02

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Jie Chen ,  Carolyn Diane Dzierba ,  Junqing Guo ,  Amy C. Hart ,  William J. Pitts ,  Sing-Yuen Sit

IPC: C07D409/04 ,  C07D403/04 ,  C07D417/04

Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

公开(公告)号：US20250074909A1

公开(公告)日：2025-03-06

申请号：US18928275

申请日：2024-10-28

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Junqing Guo ,  Amy C. Hart ,  John E. Macor ,  Michael E. Mertzman ,  William J. Pitts ,  Steven H. Spergel ,  Scott Hunter Watterson ,  Murugaiah Andappan Murugaiah Subbaiah ,  Jie Chen ,  Carolyn Diane Dzierba ,  Guanglin Luo ,  Jianliang Shi ,  Sing-Yuen Sit

IPC: C07D471/04

Abstract: Compounds having formula (I)-(IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.