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公开(公告)号：US20190389859A1
公开(公告)日：2019-12-26
申请号：US16484604
申请日：2018-02-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Junqing Guo , Amy C. Hart , John E. Macor , Michael E. Mertzman , William J. Pitts , Steven H. Spergel , Scott Hunter Watterson , Murugaiah Andappan Murugaiah Subbaiah , Jie Chen , Carolyn Diane Dzierba , Guanglin Luo , Jianliang Shi , Sing-Yuen Sit
IPC: C07D471/04
Abstract: Compounds having formula (I) (IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein: (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX).
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公开(公告)号：US20240425505A1
公开(公告)日：2024-12-26
申请号：US18817352
申请日：2024-08-28
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Guanglin Luo , Jie Chen , Carolyn Diane Dzierba , David B. Frennesson , Junqing Guo , Amy C. Hart , Xirui Hu , Michael E. Mertzman , Matthew Reiser Patton , Jianliang Shi , Steven H. Spergel , Brian Lee Venables , Yong-Jin Wu , Zili Xiao , Michael G. Yang
IPC: C07D471/04
Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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公开(公告)号：US12157733B2
公开(公告)日：2024-12-03
申请号：US17116016
申请日：2020-12-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Junqing Guo , Amy C. Hart , John E. Macor , Michael E. Mertzman , William J. Pitts , Steven H. Spergel , Scott Hunter Watterson , Murugaiah Andappan Murugaiah Subbaiah , Jie Chen , Carolyn Diane Dzierba , Guanglin Luo , Jianliang Shi , Sing-Yuen Sit
IPC: C07D471/04
Abstract: Compounds having formula (I)-(IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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公开(公告)号：US11440913B2
公开(公告)日：2022-09-13
申请号：US16758892
申请日：2018-10-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Michael E. Mertzman , Carolyn Diane Dzierba , Jason M. Guernon , Amy C. Hart , Guanglin Luo , John E. Macor , William J. Pitts , Jianliang Shi , Steven H. Spergel
IPC: A61K31/5025 , C07D487/04
Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, (I) are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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公开(公告)号：US20220315580A1
公开(公告)日：2022-10-06
申请号：US17116016
申请日：2020-12-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Junqing Guo , Amy C. Hart , John E. Macor , Michael E. Mertzman , William J. Pitts , Steven H. Spergel , Scott Hunter Watterson , Murugaiah Andappan Murugaiah Subbaiah , Jie Chen , Carolyn Diane Dzierba , Guanglin Luo , Jianliang Shi , Sing-Yuen Sit
IPC: C07D471/04
Abstract: Compounds having formula (I)-(IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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Patent Agency Ranking
6.发明授权公开(公告)号：US09987266B2
公开(公告)日：2018-06-05
申请号：US15480787
申请日：2017-04-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ryan M. Moslin , David S. Weinstein , Stephen T. Wrobleski , Yanlei Zhang , John S. Tokarski , Michael E. Mertzman , Chunjian Liu
IPC: A61K31/455 , A61K31/506
CPC classification number: A61K31/455 , A61K31/44 , A61K31/444 , A61K31/506 , C07B59/002 , C07B2200/05 , C07D213/56 , C07D213/82 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
Abstract: Compounds having the following formula I: or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα by acting on Tyk-2 to cause signal transduction inhibition.
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7.发明授权公开(公告)号：US09663467B2
公开(公告)日：2017-05-30
申请号：US15034915
申请日：2014-01-16
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ryan M. Moslin , David S. Weinstein , Stephen T. Wrobleski , Yanlei Zhang , John S. Tokarski , Michael E. Mertzman , Chunjian Liu
IPC: C07D213/56 , C07D405/12 , C07D401/12 , C07D213/82 , C07D413/12 , C07D417/12 , C07B59/00
CPC classification number: A61K31/455 , A61K31/44 , A61K31/444 , A61K31/506 , C07B59/002 , C07B2200/05 , C07D213/56 , C07D213/82 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
Abstract: Compounds having the following formula (I): or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα by acting on Tyk-2 to cause signal transduction inhibition.
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公开(公告)号：US20250074909A1
公开(公告)日：2025-03-06
申请号：US18928275
申请日：2024-10-28
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Junqing Guo , Amy C. Hart , John E. Macor , Michael E. Mertzman , William J. Pitts , Steven H. Spergel , Scott Hunter Watterson , Murugaiah Andappan Murugaiah Subbaiah , Jie Chen , Carolyn Diane Dzierba , Guanglin Luo , Jianliang Shi , Sing-Yuen Sit
IPC: C07D471/04
Abstract: Compounds having formula (I)-(IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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公开(公告)号：US12110290B2
公开(公告)日：2024-10-08
申请号：US18347703
申请日：2023-07-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Guanglin Luo , Jie Chen , Carolyn Diane Dzierba , David B. Frennesson , Junqing Guo , Amy C. Hart , Xirui Hu , Michael E. Mertzman , Matthew Reiser Patton , Jianliang Shi , Steven H. Spergel , Brian Lee Venables , Yong-Jin Wu , Zili Xiao , Michael G. Yang
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof,
are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.-
公开(公告)号：US20240109888A1
公开(公告)日：2024-04-04
申请号：US18347703
申请日：2023-07-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Guanglin Luo , Jie Chen , Carolyn Diane Dzierba , David B. Frennesson , Junqing Guo , Amy C. Hart , Xirui Hu , Michael E. Mertzman , Matthew Reiser Patton , Jianliang Shi , Steven H. Spergel , Brian Lee Venables , Yong-Jin Wu , Zili Xiao , Michael G. Yang
IPC: C07D471/04
CPC classification number: C07D471/04
Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof,
are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
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