公开(公告)号：US20220324840A1

公开(公告)日：2022-10-13

申请号：US17713598

申请日：2022-04-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Chen ,  Godwin Kwame Kumi ,  Audris Huang ,  Satheesh Kesavan Nair ,  Bharat Dinkar Shimpukade ,  Suresh Babu Vishwa Krishna Penmetsa ,  James Aaron Balog

IPC: C07D401/14 ,  A61P35/00

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein R1, R2, R4, R6, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US11267811B2

公开(公告)日：2022-03-08

申请号：US16650403

申请日：2018-09-27

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Prasada Rao Jalagam ,  Satheesh Kesavan Nair ,  Manoranjan Panda ,  Ramakanth Sarabu ,  Jacob Swidorski ,  Brett R. Beno ,  Alicia Regueiro-Ren

IPC: C07D417/14 ,  C07D405/14

Abstract: The present disclosure relates to compounds of formula I, which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.

公开(公告)号：US20200308213A1

公开(公告)日：2020-10-01

申请号：US16754381

申请日：2018-10-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Prasada Rao Jalagam ,  Satheesh Kesavan Nair ,  Manoranjan Panda ,  Alicia Regueiro-Ren

IPC: C07H19/056 ,  C07H19/24 ,  C07H19/052

Abstract: The present disclosure relates to compounds of formula I, which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.

公开(公告)号：US08987311B2

公开(公告)日：2015-03-24

申请号：US14371281

申请日：2013-01-11

Applicant: Bristol-Myers Squibb Company

Inventor： Dharmpal S. Dodd ,  Christopher P. Mussari ,  Rajeev S. Bhide ,  Satheesh Kesavan Nair ,  Venkatram Reddy Paidi ,  Sreekantha Ratna Kumar ,  Abhisek Banerjee ,  Ramesh Sistla ,  William J. Pitts ,  John Hynes

IPC: C07D401/04 ,  A61K31/44 ,  C07D471/10 ,  C07D417/14

CPC classification number: C07D471/10 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds having the following formula: (I) wherein: A is an optionally substituted triazole, or a stereoisomer or a pharmaceutically-acceptable salt thereof, are useful as kinase modulators, including IRAK-4 modulation.

Abstract translation: 具有下式的化合物：（I）其中：A是任选取代的三唑或其立体异构体或其药学上可接受的盐，可用作激酶调节剂，包括IRAK-4调节。

公开(公告)号：US20240376082A1

公开(公告)日：2024-11-14

申请号：US18740857

申请日：2024-06-25

Applicant: Bristol-Myers Squibb Company

Inventor： Yan Chen ,  Godwin Kwame Kumi ,  Audris Huang ,  Satheesh Kesavan Nair ,  Bharat Dinkar Shimpukade ,  Suresh Babu Vishwa Krishna Penmetsa ,  James Aaron Balog

IPC: C07D401/14 ,  A61P35/00

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein R1, R2, R4, R6, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US11970511B2

公开(公告)日：2024-04-30

申请号：US17251964

申请日：2019-06-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Richard A. Hartz ,  Li Xu ,  David S. Yoon ,  Alicia Regueiro-Ren ,  Prasada Rao Jalagam ,  Manoranjan Panda ,  Satheesh Kesavan Nair

IPC: C07H17/04 ,  A61P13/12

CPC classification number: C07H17/04 ,  A61P13/12

Abstract: The present disclosure relates to compounds of Formula (1), which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods making and using such compounds and compositions.

公开(公告)号：US20230303527A1

公开(公告)日：2023-09-28

申请号：US18331348

申请日：2023-06-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Chen ,  Godwin Kwame Kumi ,  Audris Huang ,  Satheesh Kesavan Nair ,  Bharat Dinkar Shimpukade ,  Suresh Babu Vishwa Krishna Penmetsa ,  James Aaron Balog

IPC: C07D401/14 ,  A61P35/00

CPC classification number: C07D401/14 ,  A61P35/00

Abstract: Disclosed are compounds of Formula (I):




or a salt thereof, wherein R1, R2, R4, R6, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US11072626B2

公开(公告)日：2021-07-27

申请号：US16754381

申请日：2018-10-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Prasada Rao Jalagam ,  Satheesh Kesavan Nair ,  Manoranjan Panda ,  Alicia Regueiro-Ren

IPC: C07H19/056 ,  C07H19/052 ,  C07H19/24

Abstract: The present disclosure relates to compounds of formula I, which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.

公开(公告)号：US11053197B2

公开(公告)日：2021-07-06

申请号：US16859103

申请日：2020-04-27

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Saleem Ahmad ,  Douglas G. Batt ,  Qingjie Liu ,  John E. Macor ,  Joseph A. Tino ,  Scott Hunter ,  Satheesh Kesavan Nair ,  Tarun Kumar Maishal

IPC: C07D401/04 ,  C07D403/04 ,  C07D487/04 ,  C07D487/10 ,  C07D209/88 ,  A61K31/4523 ,  C07D471/04 ,  A61K31/403 ,  C07D401/06 ,  C07D403/06 ,  C07D403/12 ,  C07D471/10 ,  C07D495/04

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein Q, R1a, R1b, R2a, R2b, R3, R4, R5a, R5b, R6a, R6c, R7a, R7b, R7c, and R7d are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

公开(公告)号：US20210163443A1

公开(公告)日：2021-06-03

申请号：US17108024

申请日：2020-12-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Pravin Sudhakar Shirude ,  Satheesh Kesavan Nair ,  Ramesh Kumar Sistla ,  Ashit K. Ganguly ,  Ramakanth Sarabu

IPC: C07D401/06 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

Abstract: Disclosed are compounds of Formula I, and pharmaceutically acceptable salts thereof: Also disclosed are pharmaceutical compositions thereof as well as methods for using the compounds in treating a variety of diseases such as, for example, autoimmune diseases, dry eye syndrome, fibrosis, scar formation, angiogenesis, ischemic damage, inflammatory diseases, cancers, musculoskeletal diseases, cardiovascular diseases, transplant rejection, multiple sclerosis, systemic sclerosis and neurodegenerative diseases.