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公开(公告)号：US12241116B2
公开(公告)日：2025-03-04
申请号：US18536935
申请日：2023-12-12
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Jonathan William Larson , Qun Zhong , Darren Roy Link
IPC: C12Q1/68 , C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886
Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US20240093271A1
公开(公告)日：2024-03-21
申请号：US18514645
申请日：2023-11-20
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Jonathan William Larson , Qun Zhong , Darren Roy Link
IPC: C12Q1/6816 , C12Q1/6827 , C12Q1/686
CPC classification number: C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883
Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US20230086845A1
公开(公告)日：2023-03-23
申请号：US17992304
申请日：2022-11-22
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Jonathan William Larson , Qun Zhong , Darren Roy Link
IPC: C12Q1/6816 , C12Q1/6827 , C12Q1/686
Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US11268887B2
公开(公告)日：2022-03-08
申请号：US16733137
申请日：2020-01-02
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Benjamin Miller , Brian Hutchison , Andrew Wilson , Jonathan William Larson , Qun Zhong , Yevgeny Yurkovetsky , Darren Roy Link , Mark Weary
IPC: G01N1/38 , F16K99/00 , B01L3/02 , B01L3/00 , B01F15/00 , B01F13/00 , F17D3/01 , G01N27/447 , G01N21/03 , G01N21/17
Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
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公开(公告)号：US10527529B2
公开(公告)日：2020-01-07
申请号：US15674074
申请日：2017-08-10
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Benjamin J. Miller , Brian Hutchison , Andrew Wilson , Jonathan William Larson , Qun Zhong , Yevgeny Yurkovetsky , Darren Roy Link , Mark Weary
Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
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Patent Agency Ranking
公开(公告)号：US20220213530A1
公开(公告)日：2022-07-07
申请号：US17574780
申请日：2022-01-13
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Jonathan William Larson , Qun Zhong , Darren Roy Link
IPC: C12Q1/6816 , C12Q1/6827 , C12Q1/686
Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US20220143617A1
公开(公告)日：2022-05-12
申请号：US17582441
申请日：2022-01-24
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Benjamin Miller , Brian Hutchison , Andrew Wilson , Jonathan William Larson , Qun Zhong , Yevgeny Yurkovetsky , Darren Link , Mark Weary
IPC: B01L3/00
Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
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公开(公告)号：US11077415B2
公开(公告)日：2021-08-03
申请号：US16181256
申请日：2018-11-05
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Yevgeny Yurkovetsky , Darren Roy Link , Jonathan William Larson
Abstract: The invention generally relates to methods for forming mixed droplets. In certain embodiments, methods of the invention involve forming a droplet, and contacting the droplet with a fluid stream, wherein a portion of the fluid stream integrates with the droplet to form a mixed droplet.
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公开(公告)号：US12031175B2
公开(公告)日：2024-07-09
申请号：US18514645
申请日：2023-11-20
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Jonathan William Larson , Qun Zhong , Darren Roy Link
IPC: C12Q1/68 , C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886
CPC classification number: C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q1/686 , C12Q2563/159 , C12Q2565/629 , C12Q1/686 , C12Q2537/143 , C12Q2563/159 , C12Q2565/629 , C12Q1/6827 , C12Q2531/113 , C12Q2537/143 , C12Q2563/159 , C12Q2565/629 , C12Q1/686 , C12Q2535/131 , C12Q2537/143 , C12Q2563/159 , C12Q2565/629 , C12Q1/6827 , C12Q2531/113 , C12Q2535/131 , C12Q2537/143 , C12Q2563/159 , C12Q2565/629
Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US20240132939A1
公开(公告)日：2024-04-25
申请号：US18536935
申请日：2023-12-12
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Jonathan William Larson , Qun Zhong , Darren Roy Link
IPC: C12Q1/6816 , C12Q1/6827 , C12Q1/686
CPC classification number: C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883
Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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