公开(公告)号：US20240301422A1

公开(公告)日：2024-09-12

申请号：US18661354

申请日：2024-05-10

Applicant: Biogen MA Inc.

Inventor： Holly Kordasiewicz

IPC: C12N15/113 ,  A61K9/00 ,  A61K31/7125 ,  A61K47/02 ,  A61K47/46 ,  A61P25/08 ,  A61P25/14 ,  A61P25/28

CPC classification number: C12N15/113 ,  A61K9/0019 ,  A61K31/7125 ,  A61P25/08 ,  A61P25/14 ,  A61P25/28 ,  A61K47/02 ,  A61K47/46 ,  C12N2310/11 ,  C12N2310/31 ,  C12N2310/315 ,  C12N2310/322 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/3525

Abstract: Provided are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of Tau mRNA in a cell or animal, and in certain instances reducing the amount of Tau protein in a cell or animal. Such compounds, methods, and pharmaceutical compositions are useful to ameliorate at least one symptom of a neurodegenerative disease. Such symptoms include loss of memory, loss of motor function, and increase in the number and/or volume of neurofibrillary inclusions. Such neurodegenerative diseases include tauopathies, Alzheimer's Disease, Fronto-temporal Dementia (FTD), FTDP-17, Progressive Supranuclear Palsy (PSP), Chronic Traumatic Encephalopathy (CTE), Corticobasal Ganglionic Degeneration (CBD), Epilepsy, and Dravet's Syndrome.

公开(公告)号：US11591595B2

公开(公告)日：2023-02-28

申请号：US16986770

申请日：2020-08-06

Applicant: Biogen MA Inc.

Inventor： Holly Kordasiewicz ,  Eric E. Swayze ,  Susan M. Freier ,  Huynh-Hoa Bui

IPC: C12N15/113 ,  A61K31/711 ,  C07H21/02

Abstract: Disclosed herein are antisense compounds and methods for decreasing Tau mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate Tau-associated diseases, disorders, and conditions.

公开(公告)号：US20230323351A1

公开(公告)日：2023-10-12

申请号：US18155945

申请日：2023-01-18

Applicant: Biogen MA Inc.

Inventor： Holly Kordasiewicz ,  Eric E. Swayze ,  Susan M. Freier ,  Huynh-Hoa Bui

IPC: C12N15/113 ,  A61K31/711 ,  C07H21/02

CPC classification number: C12N15/113 ,  A61K31/711 ,  C07H21/02 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346

Abstract: Disclosed herein are antisense compounds and methods for decreasing Tau mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate Tau-associated diseases, disorders, and conditions.

公开(公告)号：US20210071176A1

公开(公告)日：2021-03-11

申请号：US16986770

申请日：2020-08-06

Applicant: Biogen MA Inc.

Inventor： Holly Kordasiewicz ,  Eric E. Swayze ,  Susan M. Freier ,  Huynh-Hoa Bui

IPC: C12N15/113 ,  A61K31/711 ,  C07H21/02

Abstract: Disclosed herein are antisense compounds and methods for decreasing Tau mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate Tau-associated diseases, disorders, and conditions.

公开(公告)号：US12091662B2

公开(公告)日：2024-09-17

申请号：US18155945

申请日：2023-01-18

Applicant: Biogen MA Inc.

Inventor： Holly Kordasiewicz ,  Eric E. Swayze ,  Susan M. Freier ,  Huynh-Hoa Bui

IPC: C12N15/113 ,  A61K31/711 ,  C07H21/02 ,  C12Q1/68

CPC classification number: C12N15/113 ,  A61K31/711 ,  C07H21/02 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346 ,  C12N2310/321 ,  C12N2310/3525

Abstract: Disclosed herein are antisense compounds and methods for decreasing Tau mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate Tau-associated diseases, disorders, and conditions.

公开(公告)号：US11053498B2

公开(公告)日：2021-07-06

申请号：US16527574

申请日：2019-07-31

Applicant: Biogen MA Inc.

Inventor： Holly Kordasiewicz

IPC: C07H21/04 ,  C12N15/113 ,  A61K9/00 ,  A61P25/14 ,  A61P25/28 ,  A61P25/08 ,  A61K31/7125 ,  A61K47/02 ,  A61K47/46

Abstract: Provided are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of Tau mRNA in a cell or animal, and in certain instances reducing the amount of Tau protein in a cell or animal. Such compounds, methods, and pharmaceutical compositions are useful to ameliorate at least one symptom of a neurodegenerative disease. Such symptoms include loss of memory, loss of motor function, and increase in the number and/or volume of neurofibrillary inclusions. Such neurodegenerative diseases include tauopathies, Alzheimer's Disease, Fronto-temporal Dementia (FTD), FTDP-17, Progressive Supranuclear Palsy (PSP), Chronic Traumatic Encephalopathy (CTE), Corticobasal Ganglionic Degeneration (CBD), Epilepsy, and Dravet's Syndrome.

公开(公告)号：US10793856B2

公开(公告)日：2020-10-06

申请号：US15593173

申请日：2017-05-11

Applicant: Biogen MA Inc.

Inventor： Holly Kordasiewicz ,  Eric E. Swayze ,  Susan M. Freier ,  Huynh-Hoa Bui

IPC: C12N15/113 ,  A61K31/711 ,  C07H21/02 ,  C12Q1/68

Abstract: Disclosed herein are antisense compounds and methods for decreasing Tau mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate Tau-associated diseases, disorders, and conditions.