公开(公告)号：US20190175738A1

公开(公告)日：2019-06-13

申请号：US16211302

申请日：2018-12-06

Applicant: Biogen MA Inc.

Inventor： Lynn Edward Conley ,  Yinying Tao

IPC: A61K47/20 ,  A61K47/24 ,  C12N7/00 ,  A61K47/18 ,  A61K38/17 ,  A61K9/00 ,  C07K14/705

CPC classification number: A61K47/20 ,  A61K9/0019 ,  A61K38/1793 ,  A61K47/186 ,  A61K47/24 ,  C07K14/70578 ,  C07K2319/30 ,  C12N7/00 ,  C12N2710/16763 ,  C12N2740/13063

Abstract: Aspects of the invention provide therapeutic recombinant protein preparations and methods of preparing therapeutic recombinant protein, which methods include contacting recombinant protein preparations with zwitterionic detergent at or above critical micelle concentration of the detergent.

公开(公告)号：US10702603B2

公开(公告)日：2020-07-07

申请号：US16211302

申请日：2018-12-06

Applicant: Biogen MA Inc.

Inventor： Lynn Edward Conley ,  Yinying Tao

IPC: A61K38/00 ,  A61K47/20 ,  A61K9/00 ,  A61K47/24 ,  C07K14/705 ,  C12N7/00 ,  A61K47/18 ,  A61K38/17

Abstract: Aspects of the invention provide therapeutic recombinant protein preparations and methods of preparing therapeutic recombinant protein, which methods include contacting recombinant protein preparations with zwitterionic detergent at or above critical micelle concentration of the detergent.

公开(公告)号：US10188732B2

公开(公告)日：2019-01-29

申请号：US14419968

申请日：2013-08-06

Applicant: Biogen MA Inc.

Inventor： Lynn Edward Conley ,  Yinying Tao

IPC: A61K38/00 ,  A61K47/20 ,  C12N7/00 ,  A61K9/00 ,  A61K47/24 ,  A61K38/17 ,  A61K47/18 ,  C07K14/705

Abstract: Aspects of the invention provide therapeutic recombinant protein preparations and methods of preparing therapeutic recombinant protein, which methods include contacting recombinant protein preparations with zwitterionic detergent at or above critical micelle concentration of the detergent.