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公开(公告)号：US20190227064A1
公开(公告)日：2019-07-25
申请号：US16211154
申请日：2018-12-05
Applicant: BIOGEN MA INC.
Inventor： Gary Lewis Bloomgren , Carmen Bozic , Sophia Lee , Meena Subramanyam , Tatiana Plavina
IPC: G01N33/569
Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).
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公开(公告)号：US20160187337A1
公开(公告)日：2016-06-30
申请号：US15063777
申请日：2016-03-08
Applicant: Biogen MA Inc.
Inventor： Leonid Gorelik , Kenneth J. Simon , Meena Subramanyam , Mia Marie Rushe
IPC: G01N33/569
CPC classification number: G01N33/56983 , G01N2333/025 , G01N2469/20 , G01N2800/50
Abstract: The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject.
Abstract translation: 本公开涉及用于分析样品存在JC病毒抗体的方法和试剂。 公开了一种方法，其包括从适合于JCV抗体结合的条件下获得来自受试者（例如血浆，血清，血液，尿液或脑脊液）的生物样品，使样品与高度纯化的病毒样颗粒HPVLP接触） 在样品中检测HPVLP，并检测样品中JCV抗体与HPVLP结合的水平。在一个实施方案中，确定受试样品中抗JCV抗体的水平提供了在受试者中鉴定PML风险的方法。
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公开(公告)号：US20250164486A1
公开(公告)日：2025-05-22
申请号：US18809113
申请日：2024-08-19
Applicant: Biogen MA Inc.
Inventor： Gary Lewis Bloomgren , Carmen Bozic , Sophia Lee , Meena Subramanyam , Tatiana Plavina
IPC: G01N33/569
Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).
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公开(公告)号：US12066442B2
公开(公告)日：2024-08-20
申请号：US17393335
申请日：2021-08-03
Applicant: Biogen MA Inc.
Inventor： Gary Lewis Bloomgren , Carmen Bozic , Sophia Lee , Meena Subramanyam , Tatiana Plavina
IPC: G01N33/569
CPC classification number: G01N33/56983 , C12N2710/22011 , G01N2333/025 , G01N2469/20 , G01N2800/28 , G01N2800/2814 , G01N2800/50 , G01N2800/52
Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).
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公开(公告)号：US20210025900A1
公开(公告)日：2021-01-28
申请号：US16923043
申请日：2020-07-07
Applicant: Biogen MA Inc.
Inventor： Meena Subramanyam , Lakshimi Amaravadi , Eric Wakshull , Frances Lynn , Michael Panzara , Robin McDaid Barbour , Julie Elizabeth Taylor
Abstract: The invention relates to methods and products for the identification of a clinically significant immune response in subjects treated with a therapeutic protein. Aspects of the invention relate to methods and compositions for identifying a clinically significant immune response in patients treated with therapeutic amounts of a VLA4 binding antibody (e.g., natalizumab).
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Patent Agency Ranking
公开(公告)号：US20250020660A1
公开(公告)日：2025-01-16
申请号：US18426232
申请日：2024-01-29
Applicant: Biogen MA Inc.
Inventor： Meena Subramanyam , Lakshimi Amaravadi , Eric Wakshull , Frances Lynn , Michael Panzara , Robin McDaid Barbour , Julie Elizabeth Taylor
Abstract: The invention relates to methods and products for the identification of a clinically significant immune response in subjects treated with a therapeutic protein. Aspects of the invention relate to methods and compositions for identifying a clinically significant immune response in patients treated with therapeutic amounts of a VLA4 binding antibody (e.g., natalizumab).
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公开(公告)号：US11287423B2
公开(公告)日：2022-03-29
申请号：US16594843
申请日：2019-10-07
Applicant: Biogen MA Inc.
Inventor： Leonid Gorelik , Kenneth J. Simon , Meena Subramanyam , Mia Marie Rushe
IPC: G01N33/543
Abstract: The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles (HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP. In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject.
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公开(公告)号：US10705095B2
公开(公告)日：2020-07-07
申请号：US15616669
申请日：2017-06-07
Applicant: Biogen MA Inc.
Inventor： Meena Subramanyam , Lakshmi Amaravadi , Eric Wakshull , Frances Lynn , Michael Panzara , Robin McDaid Barbour , Julie Elizabeth Taylor
Abstract: The invention relates to methods and products for the identification of a clinically significant immune response in subjects treated with a therapeutic protein. Aspects of the invention relate to methods and compositions for identifying a clinically significant immune response in patients treated with therapeutic amounts of a VLA4 binding antibody (e.g., natalizumab).
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公开(公告)号：US20180088127A1
公开(公告)日：2018-03-29
申请号：US15616669
申请日：2017-06-07
Applicant: Biogen MA Inc.
Inventor： Meena Subramanyam , Lakshmi Amaravadi , Eric Wakshull , Frances Lynn , Michael Panzara , Robin McDaid Barbour , Julie Elizabeth Taylor
Abstract: The invention relates to methods and products for the identification of a clinically significant immune response in subjects treated with a therapeutic protein. Aspects of the invention relate to methods and compositions for identifying a clinically significant immune response in patients treated with therapeutic amounts of a VLA4 binding antibody (e.g., natalizumab).
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公开(公告)号：US10677803B2
公开(公告)日：2020-06-09
申请号：US16115350
申请日：2018-08-28
Applicant: BIOGEN MA INC.
Inventor： Gary Lewis Bloomgren , Carmen Bozic , Sophia Lee , Amy Pace , Tatiana Plavina , Meena Subramanyam
Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).
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