公开(公告)号：US20160287211A1

公开(公告)日：2016-10-06

申请号：US15085380

申请日：2016-03-30

Applicant: Ralph S. DaCosta ,  Brian C. Wilson ,  Israel Veilleux ,  Jin Ho Chang ,  Jeeun Kang ,  Yangmo Yoo ,  Tai-Kyong Song

Inventor： Ralph S. DaCosta ,  Brian C. Wilson ,  Israel Veilleux ,  Jin Ho Chang ,  Jeeun Kang ,  Yangmo Yoo ,  Tai-Kyong Song

IPC: A61B8/00 ,  A61B8/08 ,  A61B8/14

CPC classification number: A61B8/4416 ,  A61B5/0035 ,  A61B5/0071 ,  A61B5/0095 ,  A61B5/7425 ,  A61B8/13 ,  A61B8/14 ,  A61B8/145 ,  A61B8/4405 ,  A61B8/4444 ,  A61B8/4472 ,  A61B8/48 ,  A61B8/5261 ,  G06T7/0012

Abstract: Various embodiments are described herein for a method, apparatus and system for performing multi-modal imaging using a common imaging probe having various modes of operation including a fluorescent (FL) imaging mode and at least one of an ultrasound (US) imaging mode, a photoacoustic (PA) imaging mode and a combined US/PA imaging mode. Molecular/functional information may be obtained from FL and PA imaging and anatomical information may be obtained from ultrasound (US) imaging. The system may be implemented to provide for images from each modality in real time as well as provide for co-registration of these images. Experimental results demonstrate that combining the imaging modalities does not significantly compromise the performance of each of the separate US, PA, and FL imaging techniques, while enabling multi-modality registration.

Abstract translation: 在这里描述了用于使用具有各种操作模式的共同成像探头进行多模态成像的方法，装置和系统，包括荧光（FL）成像模式和超声（US）成像模式， 光声（PA）成像模式和US / PA成像模式组合。 可以从FL和PA成像获得分子/功能信息，并且可以从超声（US）成像获得解剖信息。 可以实施该系统以实时地提供来自每个模态的图像，以及提供这些图像的共同配准。 实验结果表明，组合成像模式并不会显着损害每个单独的美国，美国和加拿大成像技术的性能，同时实现多模式注册。

公开(公告)号：US20130178748A1

公开(公告)日：2013-07-11

申请号：US13625867

申请日：2012-09-24

Applicant: Alexandre Douplik ,  Desmond C. Adler ,  Brian C. Wilson ,  Norman Marcon

Inventor： Alexandre Douplik ,  Desmond C. Adler ,  Brian C. Wilson ,  Norman Marcon

IPC: A61B5/00

CPC classification number: A61B5/0075 ,  A61B1/043 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/4233

Abstract: A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume THB and oxygenation SO2. A pull-back approach of spectral data acquisition is disclosed which takes into account tissue motility in esophagus and measurement geometry peculiarities. The pull-back approach provides a significant improvement of measurement reproducibility and reduction of data deviation by 75-100%, resulting in a better discrimination between different histological groups.

Abstract translation: 描述了一种使用在485,513,598和629nm的四个不同波长的最小四个波长进行漫反射测量的鉴别功能来计算发育不良与巴雷特食管（无论是否具有炎性成分）之间的统计学显着性差异的方法。 发现的鉴别功能取决于局部血液成分体积THB和氧合SO2。 公开了光谱数据采集的回退方法，其考虑了食管中的组织运动和测量几何特征。 拉回方法显着提高了测量重现性，并将数据偏差减少了75-100％，从而导致不同组织学组之间的更好区分。

公开(公告)号：US07771426B2

公开(公告)日：2010-08-10

申请号：US10969910

申请日：2004-10-22

Applicant: Shane Burch ,  Brian C. Wilson ,  Stuart K. Bisland

Inventor： Shane Burch ,  Brian C. Wilson ,  Stuart K. Bisland

IPC: A61B17/56

CPC classification number: A61N5/062 ,  A61B17/864 ,  A61B18/22 ,  A61N5/0601

Abstract: Photodynamic therapy (PDT) is used in the case of bone. A photosensitizing drug is administered to a mammal. A bone insertion member is secured into bone. A fiber optic cable sheath extends from within the bone insertion member and is accessible. A fiber optic cable is inserted in the fiber optic cable sheath to deliver light to the bone. A locking member is then attached to the insertion member. Non-thermal light at a specific wavelength is then delivered to activate the drug. The insertion member and the fiber optic cable sheath may remain inside the mammal for further photodynamic therapy.

Abstract translation: 在骨骼的情况下使用光动力疗法（PDT）。 向哺乳动物施用光敏药物。 骨插入构件被固定到骨中。 光缆护套从骨插入构件内部延伸并且可接近。 将光纤电缆插入光缆护套中以将光传送到骨骼。 然后将锁定构件附接到插入构件。 然后递送特定波长的非热光以激活药物。 插入构件和光缆护套可以保留在哺乳动物内用于进一步的光动力学治疗。

公开(公告)号：US20080255461A1

公开(公告)日：2008-10-16

申请号：US12079418

申请日：2008-03-26

Applicant: Robert Weersink ,  Lee Chin ,  John Trachtenberg ,  Alex Vitkin ,  William Whelan ,  Brian C. Wilson

Inventor： Robert Weersink ,  Lee Chin ,  John Trachtenberg ,  Alex Vitkin ,  William Whelan ,  Brian C. Wilson

IPC: A61B5/00 ,  A61B18/18

CPC classification number: A61B18/24 ,  A61B5/0084 ,  A61B5/0086 ,  A61B2562/0233 ,  A61B2562/043 ,  A61B2562/228

Abstract: Multiple site information of light intensity is obtained by application of a multiple-fibre probe in a real-time optical monitoring system. The multiple-fibre probe includes a plurality of optical fibres distributed along the length of the probe. Each optical fibre may be is switchable between the mode for transmitting optical signal into the malignant tissue and the mode for collecting the optical signal from the same tissue. Thus the numbers of the probes can be minimized for collecting multiple site light information and the irritation to the tissue is reduced. A method of using such a probe to determine coagulated boundary in thermal or other treatment is also described.

Abstract translation: 通过在实时光学监控系统中应用多光纤探头获得光强度的多个位置信息。 多光纤探头包括沿着探头的长度分布的多根光纤。 每个光纤可以在用于将光信号发送到恶性组织的模式和从相同组织收集光信号的模式之间切换。 因此，可以将探针的数量最小化以收集多个位点光信息，并减少对组织的刺激。 还描述了使用这种探针以确定热或其它处理中的凝固边界的方法。

公开(公告)号：US08407652B2

公开(公告)日：2013-03-26

申请号：US12972879

申请日：2010-12-20

Applicant: Anthony D. Drumm ,  Jagannathan Narasimhan ,  Lakshmi N. Reddy ,  Louise H. Trevillyan ,  Brian C. Wilson

Inventor： Anthony D. Drumm ,  Jagannathan Narasimhan ,  Lakshmi N. Reddy ,  Louise H. Trevillyan ,  Brian C. Wilson

IPC: G06F17/50

CPC classification number: G06F17/505

Abstract: A task-based multi-process design synthesis methodology relies on a plurality of child processes to assist a parent process in performing optimizations on an integrated circuit design. Objects from an integrated circuit design are grouped into subsets and assigned to child processes, with each child process performing a transform on each of the objects in the subset assigned to that child process and determining which of the objects in the subset are candidate objects for which performance of the transform has been successful. The child processes then notify the parent process of those objects that qualify as candidate objects, so that the parent process only has to perform the transform on the candidate objects, thereby relieving the parent process from the overhead associated with performing the transform on non-candidate objects for which the transform has been determined by the child processes as not being successful.

Abstract translation: 基于任务的多进程设计合成方法依赖于多个子进程来辅助父进程对集成电路设计进行优化。 来自集成电路设计的对象被分组成子集并被分配给子进程，每个子进程对分配给该子进程的子集中的每个对象执行变换，并且确定该子集中的哪些对象是候选对象 变革的表现已经取得成功。 然后，子进程通知那些符合候选对象的那些对象的父进程，以便父进程只需对候选对象执行转换，从而将父进程从与非候选对象执行转换相关的开销中解除 子进程已将该转换确定为未成功的对象。

公开(公告)号：US08407638B2

公开(公告)日：2013-03-26

申请号：US12355757

申请日：2009-01-16

Applicant: Victor A. Acuna ,  Robert L. Kanzelman ,  Scott H. Mack ,  Brian C. Wilson

Inventor： Victor A. Acuna ,  Robert L. Kanzelman ,  Scott H. Mack ,  Brian C. Wilson

IPC: G06F17/50

CPC classification number: G06F17/5045 ,  G01R31/31835

Abstract: In a first aspect, a first method of designing a circuit is provided. The first method includes the steps of (1) providing a model of an original circuit design including a latch; (2) providing a model of a modified version of the original circuit design, wherein the modified version of the original circuit design includes a set of latches associated with the latch of the original circuit design and voting logic having inputs coupled to respective outputs of latches in the latch set; and (3) during Boolean equivalency checking (BEC), injecting an error on at most a largest minority of the inputs of the voting logic to test the voting logic function.

Abstract translation: 在第一方面，提供了设计电路的第一种方法。 第一种方法包括以下步骤：（1）提供包括闩锁的原始电路设计的模型; （2）提供原始电路设计的修改版本的模型，其中原始电路设计的修改版本包括与原始电路设计的锁存器相关联的一组锁存器和具有耦合到锁存器的相应输出的输入的投票逻辑 在锁定组中; 和（3）在布尔等价性检查（BEC）期间，在表决逻辑的最多输入的最多少量输入错误，以测试投票逻辑功能。

公开(公告)号：US20120159417A1

公开(公告)日：2012-06-21

申请号：US12972879

申请日：2010-12-20

Applicant: Anthony D. Drumm ,  Jagannathan Narasimhan ,  Lakshmi N. Reddy ,  Louise H. Trevillyan ,  Brian C. Wilson

Inventor： Anthony D. Drumm ,  Jagannathan Narasimhan ,  Lakshmi N. Reddy ,  Louise H. Trevillyan ,  Brian C. Wilson

IPC: G06F17/50

CPC classification number: G06F17/505

Abstract: A task-based multi-process design synthesis methodology relies on a plurality of child processes to assist a parent process in performing optimizations on an integrated circuit design. Objects from an integrated circuit design are grouped into subsets and assigned to child processes, with each child process performing a transform on each of the objects in the subset assigned to that child process and determining which of the objects in the subset are candidate objects for which performance of the transform has been successful. The child processes then notify the parent process of those objects that qualify as candidate objects, so that the parent process only has to perform the transform on the candidate objects, thereby relieving the parent process from the overhead associated with performing the transform on non-candidate objects for which the transform has been determined by the child processes as not being successful.

Abstract translation: 基于任务的多进程设计合成方法依赖于多个子进程来辅助父进程对集成电路设计进行优化。 来自集成电路设计的对象被分组成子集并被分配给子进程，每个子进程对分配给该子进程的子集中的每个对象执行变换，并且确定该子集中的哪些对象是候选对象 变革的表现已经取得成功。 然后，子进程通知那些符合候选对象的那些对象的父进程，以便父进程只需对候选对象执行转换，从而将父进程从与非候选对象执行转换相关的开销中解除 子进程已将该转换确定为未成功的对象。

公开(公告)号：US20100087741A1

公开(公告)日：2010-04-08

申请号：US12572473

申请日：2009-10-02

Applicant: Alexandre Douplik ,  Desmond C. Adler ,  Brian C. Wilson ,  Norman Marcon

Inventor： Alexandre Douplik ,  Desmond C. Adler ,  Brian C. Wilson ,  Norman Marcon

IPC: A61B6/00

CPC classification number: A61B5/0075 ,  A61B1/043 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/4233

Abstract: A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume THB and oxygenation SO2. A pull-back approach of spectral data acquisition is disclosed which takes into account tissue motility in esophagus and measurement geometry peculiarities. The pull-back approach provides a significant improvement of measurement reproducibility and reduction of data deviation by 75-100%, resulting in a better discrimination between different histological groups.

Abstract translation: 描述了一种使用在485,513,598和629nm的四个不同波长的最小四个波长进行漫反射测量的鉴别功能来计算发育不良与巴雷特食管（无论是否具有炎性成分）之间的统计学显着性差异的方法。 发现的鉴别功能取决于局部血液成分体积THB和氧合SO2。 公开了光谱数据采集的回退方法，其考虑了食管中的组织运动和测量几何特征。 拉回方法显着提高了测量重现性，并将数据偏差减少了75-100％，从而导致不同组织学组之间的更好区分。

公开(公告)号：US20090241082A1

公开(公告)日：2009-09-24

申请号：US12051440

申请日：2008-03-19

Applicant: Michael D. Amundson ,  David A. Lawson ,  Brian C. Wilson

Inventor： Michael D. Amundson ,  David A. Lawson ,  Brian C. Wilson

IPC: G06F17/50

CPC classification number: G06F17/505 ,  G06F2217/12 ,  Y02P90/265

Abstract: A method, system and program product are described for implementing an integrated circuit. Synthesis tools and a continuum of physical constraints are used to generate a physical realization of a circuit from a hierarchy of logical circuits. Missing physical constraints are generated based on the behavior of the logical circuits, technology rules, timing constraints, and user controls. These constraints are refined throughout the process to produce an accurate physical realization. Generation of the physical constraints is user-controlled, allowing for a full continuum of input.

Abstract translation: 描述了用于实现集成电路的方法，系统和程序产品。 合成工具和物理约束的连续体被用于从逻辑电路的层级生成电路的物理实现。 基于逻辑电路，技术规则，时序约束和用户控制的行为产生缺少的物理约束。 这些限制在整个过程中得到改进，以产生精确的物理实现。 物理约束的产生是用户控制的，允许完整的输入连续。

公开(公告)号：US5275160A

公开(公告)日：1994-01-04

申请号：US641152

申请日：1991-01-14

Applicant: Lothar Lilge ,  Brian C. Wilson ,  Thomas Haw

Inventor： Lothar Lilge ,  Brian C. Wilson ,  Thomas Haw

IPC: G01N21/64 ,  A61B5/00

CPC classification number: G01N21/7703 ,  G01N21/6428 ,  G01N2021/6434 ,  G01N2021/772 ,  G01N2021/7786

Abstract: The invention features a probe for radiance dosimetry. The probe includes a tip portion containing a fluorescent dye connected to a translucent spacer element.

Abstract translation: 本发明的特征在于用于辐射剂量测定的探针。 探针包括含有连接到半透明间隔元件的荧光染料的尖端部分。