公开(公告)号：US11067575B2

公开(公告)日：2021-07-20

申请号：US16598433

申请日：2019-10-10

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel Scherer ,  Samuel Njoroge ,  Jingqing Huang

IPC: G01N33/543 ,  G01N33/566 ,  A61B5/1459 ,  G01N21/41 ,  G01N33/552 ,  A61B5/1491

Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

公开(公告)号：US11674960B2

公开(公告)日：2023-06-13

申请号：US17344870

申请日：2021-06-10

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel Scherer ,  Samuel Njoroge ,  Jingqing Huang

IPC: G01N33/543 ,  G01N33/566 ,  A61B5/1459 ,  G01N21/41 ,  G01N33/552 ,  A61B5/1491

CPC classification number: G01N33/566 ,  A61B5/1459 ,  G01N21/41 ,  G01N33/54373 ,  G01N33/552 ,  A61B5/1491 ,  A61B2562/0233 ,  A61B2562/043 ,  G01N2201/068 ,  G01N2201/08

Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

公开(公告)号：US10175235B2

公开(公告)日：2019-01-08

申请号：US15157346

申请日：2016-05-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel Scherer ,  Samuel Njoroge ,  Jingqing Huang

IPC: G01N33/543 ,  G01N33/566 ,  A61B5/1459 ,  G01N21/41 ,  G01N33/552 ,  A61B5/1491

Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

公开(公告)号：US10481157B2

公开(公告)日：2019-11-19

申请号：US16206294

申请日：2018-11-30

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel Scherer ,  Samuel Njoroge ,  Jingqing Huang

IPC: G01N33/543 ,  G01N33/566 ,  A61B5/1459 ,  G01N21/41 ,  G01N33/552 ,  A61B5/1491

Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

公开(公告)号：US09435803B2

公开(公告)日：2016-09-06

申请号：US13684020

申请日：2012-11-21

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel Scherer ,  Samuel Njoroge ,  Jingqing Huang

IPC: G01N33/543 ,  G01N33/566 ,  A61B5/1459 ,  A61B5/1491

CPC classification number: G01N33/566 ,  A61B5/1459 ,  A61B5/1491 ,  A61B2562/0233 ,  A61B2562/043 ,  G01N21/41 ,  G01N33/54373 ,  G01N33/552 ,  G01N2201/068 ,  G01N2201/08

Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

Abstract translation: 根据本公开的可植入诊断装置提供各种益处，例如紧凑的尺寸，从而允许将装置植入动画物体内; 由于结合廉价的检测电路和使用传统的IC制造技术而导致的低成本; 通过加热可重复使用，从而允许执行多个诊断测试而不丢弃设备; 以及允许同时或不同时间执行同时和/或顺序诊断测试以检测一个或多个相似或不同的靶分子的配置。

公开(公告)号：US09037209B2

公开(公告)日：2015-05-19

申请号：US13706668

申请日：2012-12-06

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  SANOFI

Inventor： Axel Scherer ,  Remi Brouard, III ,  Emil P. Kartalov ,  Jingqing Huang

IPC: A61B5/1455 ,  A61B5/1459 ,  A61B3/10 ,  A61B5/145 ,  A61B5/00 ,  A61B5/20 ,  A61B5/1491 ,  A61B5/01

CPC classification number: A61B5/1459 ,  A61B3/10 ,  A61B5/0002 ,  A61B5/01 ,  A61B5/14507 ,  A61B5/1451 ,  A61B5/14546 ,  A61B5/1491 ,  A61B5/20 ,  A61B5/418 ,  A61B5/42 ,  A61B5/4337 ,  A61B5/6848 ,  A61B5/6852 ,  A61B5/6866 ,  A61B5/7278 ,  A61B2560/0219 ,  A61B2560/0233

Abstract: An implantable diagnostic device in accordance with the present disclosure includes a probe assembly that can be implemented in a variety of ways. A few example implementations include: a needle inside which is located a bio-sensor chip (the needle being insertable into a human being); a compact package containing the bio-sensor chip (the compact package configured for placement inside a catheter); or a silicon-based bio-sensor package configured for insertion into a vein.

Abstract translation: 根据本公开的可植入诊断装置包括可以以各种方式实现的探针组件。 一些示例性实现包括：位于其内的针，其位于生物传感器芯片（针可插入人体中）; 包含生物传感器芯片的紧凑型封装（被配置用于放置在导管内的紧凑封装）; 或被配置为插入静脉中的硅基生物传感器封装。