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    Optical resonator diagnostic device and methods of use
    1.
    发明授权
    Optical resonator diagnostic device and methods of use 有权
    光谐振器诊断装置及其使用方法

    公开(公告)号：US09435803B2

    公开(公告)日：2016-09-06

    申请号：US13684020

    申请日：2012-11-21

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

    Inventor： Axel Scherer ,  Samuel Njoroge ,  Jingqing Huang

    IPC: G01N33/543 ,  G01N33/566 ,  A61B5/1459 ,  A61B5/1491

    CPC classification number: G01N33/566 ,  A61B5/1459 ,  A61B5/1491 ,  A61B2562/0233 ,  A61B2562/043 ,  G01N21/41 ,  G01N33/54373 ,  G01N33/552 ,  G01N2201/068 ,  G01N2201/08

    Abstract: An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low cost due to incorporation of inexpensive detection circuitry and the use of conventional IC fabrication techniques; re-usability by heating thereby allowing multiple diagnostic tests to be performed without discarding the device; and a configuration that allows performing of simultaneous and/or sequential diagnostic tests for detecting one or more similar or dissimilar target molecules concurrently or at different times.

    Abstract translation: 根据本公开的可植入诊断装置提供各种益处，例如紧凑的尺寸，从而允许将装置植入动画物体内; 由于结合廉价的检测电路和使用传统的IC制造技术而导致的低成本; 通过加热可重复使用，从而允许执行多个诊断测试而不丢弃设备; 以及允许同时或不同时间执行同时和/或顺序诊断测试以检测一个或多个相似或不同的靶分子的配置。

    METHODS AND APPARATUSES FOR NUCLEIC ACID PURIFICATION
    3.
    发明申请
    METHODS AND APPARATUSES FOR NUCLEIC ACID PURIFICATION 有权
    用于核酸净化的方法和装置

    公开(公告)号：US20140134078A1

    公开(公告)日：2014-05-15

    申请号：US14069697

    申请日：2013-11-01

    Applicant: California Institute of Technology

    Inventor： Samuel Njoroge ,  George Maltezos ,  Axel Scherer ,  John B. Gorman

    IPC: C12N15/10

    CPC classification number: C12N15/101 ,  B01D15/22

    Abstract: An apparatus for purifying nucleic acid can include a disposable cartridge having a layered configuration, and a disposable syringe for coupling to the disposable cartridge such that a fluid can be delivered to or withdrawn fluid from the disposable cartridge using the syringe. At least one layer of the disposable cartridge can include a cut-out for forming a functional unit of the disposable cartridge, and at least one layer of the disposable cartridge can be joined to an adjacent layer of the disposable cartridge by an adhesive material layer. The functional unit can include a fluid channel between an access port on the first surface of the disposable cartridge and the fluid pouch. The apparatus can include a disposable silica-containing material for binding with the nucleic acid. The apparatus can include a heating element and a temperature sensor for heating the disposable silica-containing material.

    Abstract translation: 用于纯化核酸的装置可以包括具有分层构造的一次性盒，以及用于连接到一次性盒的一次性注射器，使得可以使用注射器将流体从一次性盒输送到或从其中抽出流体。 一次性盒的至少一层可以包括用于形成一次性盒的功能单元的切口，并且一次性盒的至少一层可以通过粘合材料层连接到一次性盒的相邻层。 功能单元可以包括在一次性盒的第一表面上的进入端口和流体袋之间的流体通道。 该装置可以包括用于与核酸结合的一次性含二氧化硅的材料。 该装置可以包括用于加热一次性二氧化硅的材料的加热元件和温度传感器。

    Methods and devices for sample lysis
    5.
    发明授权
    Methods and devices for sample lysis 有权
    样品溶解的方法和装置

    公开(公告)号：US09580679B2

    公开(公告)日：2017-02-28

    申请号：US14033365

    申请日：2013-09-20

    Applicant: California Institute of Technology

    Inventor： Samuel Njoroge ,  John Gorman ,  George Maltezos ,  Axel Scherer

    IPC: C12N1/06 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  B01J19/24 ,  G01N27/447

    CPC classification number: C12M47/06 ,  B01L3/5027 ,  B01L7/52 ,  B01L2300/1883 ,  C12M21/00 ,  C12N1/06 ,  C12N1/066 ,  G01N27/44791

    Abstract: Disclosed herein are methods and systems for use in preparing a sample. The methods and systems may be used for lysing one or more structures in a sample (e.g., cells, viral particles, etc.). The methods and compositions may comprise a microfluidic chip or use thereof. The microfluidic chips disclosed herein may comprise (a) a substrate comprising a chamber, wherein at least one mechanical element may be located within the chamber; (b) a thermal element in contact with the chamber; and (c) at least one aperture within the surface of the substrate, wherein the aperture may be configured to insulate the chamber.

    Abstract translation: 本文公开了用于制备样品的方法和系统。 方法和系统可用于裂解样品中的一种或多种结构（例如，细胞，病毒颗粒等）。 所述方法和组合物可以包含微流控芯片或其用途。 本文公开的微流体芯片可以包括（a）包括腔室的基底，其中至少一个机械元件可以位于腔室内; （b）与所述室接触的热元件; 以及（c）在所述基底表面内的至少一个孔，其中所述孔可以被配置为使所述腔绝缘。

    Methods and apparatuses for nucleic acid purification
    8.
    发明授权
    Methods and apparatuses for nucleic acid purification 有权

    公开(公告)号：US09624487B2

    公开(公告)日：2017-04-18

    申请号：US14069697

    申请日：2013-11-01

    Applicant: California Institute of Technology

    Inventor： Samuel Njoroge ,  George Maltezos ,  Axel Scherer ,  John B. Gorman

    IPC: C12N15/10 ,  B01D15/22

    CPC classification number: C12N15/101 ,  B01D15/22

    Abstract: An apparatus for purifying nucleic acid can include a disposable cartridge having a layered configuration, and a disposable syringe for coupling to the disposable cartridge such that a fluid can be delivered to or withdrawn fluid from the disposable cartridge using the syringe. At least one layer of the disposable cartridge can include a cut-out for forming a functional unit of the disposable cartridge, and at least one layer of the disposable cartridge can be joined to an adjacent layer of the disposable cartridge by an adhesive material layer. The functional unit can include a fluid channel between an access port on the first surface of the disposable cartridge and the fluid pouch. The apparatus can include a disposable silica-containing material for binding with the nucleic acid. The apparatus can include a heating element and a temperature sensor for heating the disposable silica-containing material.

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