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公开(公告)号：US12000058B2
公开(公告)日：2024-06-04
申请号：US18169365
申请日：2023-02-15
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Ozan Akkus , Mousa Younesi , Umit Levent Erol
Abstract: A method for producing an electrocompacted and aligned strand is disclosed. The method includes the steps of: providing a channel having an anode on one side and a cathode on the other side separated by a non-conductive material to form an electrode; dispensing a solution comprising one or more electrocompactable and alignable molecules, nanoparticles or microparticles with ampholytic nature into the channel to complete a circuit between the anode and the cathode; applying a DC current in the range of 1-200 volts to the electrode through the solution in the channel to form an electrocompacted and aligned strand; and transferring the aligned strand out of the electrode. The one or more electrocompactable and alignable molecules, nanoparticles or microparticles with ampholytic nature can comprise collagen molecules that have different charges at different pH values. Materials including electrochemically aligned and compacted compounds are also disclosed.
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公开(公告)号：US10017868B2
公开(公告)日：2018-07-10
申请号：US14766656
申请日：2014-02-11
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Ozan Akkus , Vipuil Kishore , Mousa Younesi , Anowarul Islam
CPC classification number: C25D1/18 , A61L26/0033 , A61L27/24 , A61L27/26 , B05D1/18 , C07K14/78 , D01D5/0076 , D01F4/00
Abstract: Electrochemically aligned and compacted molecules, nanoparticles and microparticles with ampholytic nature, such as collagen, elastin, keratin and charged nanoparticle materials, methods of making and using the materials and associated production-related devices. In one embodiment, a device for producing continuous electrochemically aligned strands, threads or fibers is disclosed. In a further embodiment, fabrication of compositionally and geometrically complex anatomical forms by 3D-electrochemical compaction of biomolecules is disclosed. In yet another embodiment, methods for fabricating patterned lattice structures, in particular having controlled pore size and morphology, and the lattice structures themselves are also disclosed.
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公开(公告)号：US11618961B2
公开(公告)日：2023-04-04
申请号：US16605859
申请日：2018-04-20
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Ozan Akkus , Mousa Younesi , Umit Levent Erol
Abstract: Devices suitable for the production of electrochemically aligned materials such as strands, threads or fibers. The device includes a substantially horizontally aligned electrochemical cell in one embodiment, with the arrangement producing highly compacted materials. Materials including electrochemically aligned and compacted compounds are also disclosed, along with methods for making and using the materials.
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公开(公告)号：US11306406B2
公开(公告)日：2022-04-19
申请号：US16028926
申请日：2018-07-06
Applicant: CASE WESTERN RESERVE UNIVERSITY
Inventor： Ozan Akkus , Vipuil Kishore , Mousa Younesi , Anowarul Islam
Abstract: Electrochemically aligned and compacted molecules, nanoparticles and microparticles with ampholytic nature, such as collagen, elastin, keratin and charged nanoparticle materials, methods of making and using the materials and associated production-related devices. In one embodiment, a device for producing continuous electrochemically aligned strands, threads or fibers is disclosed. In a further embodiment, fabrication of compositionally and geometrically complex anatomical forms by 3D-electrochemical compaction of biomolecules is disclosed. In yet another embodiment, methods for fabricating patterned lattice structures, in particular having controlled pore size and morphology, and the lattice structures themselves are also disclosed.
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