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    METHODS AND DEVICES FOR DIAGNOSIS OF PARTICLES IN BIOLOGICAL FLUIDS
    2.
    发明申请
    METHODS AND DEVICES FOR DIAGNOSIS OF PARTICLES IN BIOLOGICAL FLUIDS 审中-公开
    用于诊断生物流体中颗粒的方法和装置

    公开(公告)号：US20160130632A1

    公开(公告)日：2016-05-12

    申请号：US14897432

    申请日：2014-06-11

    Applicant: CASE WESTERN RESERVE UNIVERSITY

    Inventor： Ozan Akkus ,  Mikhail Slipchenko ,  Anna Akkus ,  Shan Yang ,  Bolan Li

    IPC: C12Q1/40 ,  G01N1/40 ,  G01N21/65 ,  C12Q1/37

    CPC classification number: C12Q1/40 ,  C12Q1/37 ,  G01N1/4077 ,  G01N21/65 ,  G01N2001/4088 ,  G01N2201/121 ,  G01N2333/928 ,  G01N2333/958 ,  G01N2800/107 ,  G01N2800/345

    Abstract: Methods for determining whether certain compounds, in particular crystals, are present in a sample of a biological fluid that indicates an individual has a particular disease or condition, such as but not limited to gout, pseudogout or urinary tract stones. In some embodiments, the methods include the steps of digestion and filtration of a sample of synovial fluid in order to isolate, if present, monosodium urate monohydrate (MSU), calcium pyrophosphate dihydrate (CPPD), or calcium phosphate crystals from the sample, wherein the filtrate is analyzed with a Raman device to ascertain the presence and type of the crystals. Devices for performing steps of the method are disclosed.

    Abstract translation: 用于确定特定化合物，特别是晶体是否存在于指示个体的生物流体样品中具有特定疾病或病症（例如但不限于痛风，假结肠或泌尿道结石）的方法。 在一些实施方案中，所述方法包括以下步骤：消化和过滤滑液样品，以便从样品中分离（如果存在的话）单酸一钠水溶液（MSU），焦磷酸钙二水合物（CPPD）或磷酸钙晶体，其中 用拉曼装置分析滤液以确定晶体的存在和类型。 公开了用于执行该方法的步骤的装置。

    Multifocal hyperspectral raman system and methods for imaging of materials
    4.
    发明授权
    Multifocal hyperspectral raman system and methods for imaging of materials 有权

    公开(公告)号：US10024798B2

    公开(公告)日：2018-07-17

    申请号：US14600603

    申请日：2015-01-20

    Applicant: CASE WESTERN RESERVE UNIVERSITY

    Inventor： Ozan Akkus ,  Shan Yang

    IPC: G01N21/65 ,  G01J3/28 ,  G01J3/44

    Abstract: A hyperspectral Raman imaging system having the ability to focus on excitation laser beam over a relatively wide field of view due to the use of a lens array, in particular a microlens array. Hyperspectral selection is provided in one embodiment through the use of dual-axis controlled dielectric filtration. Methods for analyzing materials with the system are disclosed. The device or system can be used in generally any application where investigation of materials is required.

    Methods and devices for diagnosis of particles in biological fluids
    5.
    发明授权
    Methods and devices for diagnosis of particles in biological fluids 有权

    公开(公告)号：US10822635B2

    公开(公告)日：2020-11-03

    申请号：US16111798

    申请日：2018-08-24

    Applicant: CASE WESTERN RESERVE UNIVERSITY

    Inventor： Ozan Akkus ,  Mikhail Slipchenko ,  Anna Akkus ,  Shan Yang ,  Bolan Li

    IPC: C12M1/00 ,  C12Q1/40 ,  G01N21/65 ,  C12Q1/37 ,  G01N1/40

    Abstract: Methods for determining whether certain compounds, in particular crystals, are present in a sample of a biological fluid that indicates an individual has a particular disease or condition, such as but not limited to gout, pseudogout or urinary tract stones. In some embodiments, the methods include the steps of digestion and filtration of a sample of synovial fluid in order to isolate, if present, monosodium urate monohydrate (MSU), calcium pyrophosphate dihydrate (CPPD), or calcium phosphate crystals from the sample, wherein the filtrate is analyzed with a Raman device to ascertain the presence and type of the crystals. Devices for performing steps of the method are disclosed.

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