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公开(公告)号：US12216116B2
公开(公告)日：2025-02-04
申请号：US17579528
申请日：2022-01-19
Applicant: CORNELL UNIVERSITY
Inventor： Sasank Vemulapati , David Erickson
IPC: G01N33/543 , G01N1/40 , G01N33/569
Abstract: The present disclosure relates to, inter alia, devices, systems, and methods for use in the magnetic separation of biological entities from fluid samples. This device includes a magnetic separation chamber configured to receive a fluid sample for magnetic separation, where the magnetic separation chamber includes at least two magnets mounted on the surface or in the wall of the magnetic separation chamber. The device also includes a force provider configured to move the magnetic separation chamber in a side-to-side motion to mix and/or magnetize the fluid sample. In one embodiment, the magnetic separation chamber is in a form of a sleeve and comprises a substantially central channel for loading a vessel containing the fluid sample therein. The systems and methods of the present disclosure involve the use of this device to separate biological entities from fluid samples.
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公开(公告)号：US11262352B2
公开(公告)日：2022-03-01
申请号：US17261855
申请日：2019-07-22
Applicant: CORNELL UNIVERSITY
Inventor： Sasank Vemulapati , David Erickson
IPC: G01N33/50 , G01N33/543 , G01N33/569 , G01N1/40
Abstract: The present disclosure relates to, inter alia, devices, systems, and methods for use in the magnetic separation of biological entities from fluid samples. This device includes a magnetic separation chamber configured to receive a fluid sample for magnetic separation, where the magnetic separation chamber includes at least two magnets mounted on the surface or in the wall of the magnetic separation chamber. The device also includes a force provider configured to move the magnetic separation chamber in a side-to-side motion to mix and/or magnetize the fluid sample. In one embodiment, the magnetic separation chamber is in a form of a sleeve and comprises a substantially central channel for loading a vessel containing the fluid sample therein. The systems and methods of the present disclosure involve the use of this device to separate biological entities from fluid samples.
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公开(公告)号：US20200291343A1
公开(公告)日：2020-09-17
申请号：US16832906
申请日：2020-03-27
Applicant: CORNELL UNIVERSITY
Inventor： David Erickson , Perry M. Schein
Abstract: An optofluidic photoreactor including an optical waveguide having an input, characterized by an evanescent optical field confined along an outer surface of the optical waveguide produced by radiation propagating in the optical waveguide, means for inputting light to the input of the optical waveguide, and a photoactive material disposed substantially only within the evanescent field. A method for optically activating a photoactive material in an optofluidic photoreactor to convert carbon dioxide and water into other molecules that may be useful as a fuel or a chemical feedstock.
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公开(公告)号：US20160080548A1
公开(公告)日：2016-03-17
申请号：US14804386
申请日：2015-07-21
Applicant: Cornell University
Inventor： David Erickson , Seoho Lee , Dakota O'Dell , Saurabh Mehta , Vlad-Victor Oncescu , Matthew Mancuso
CPC classification number: H04M1/72527 , G01N21/78 , G01N21/80 , G01N21/8483 , G01N33/48785 , G01N2021/7759 , G01N2201/0221 , G01N2201/062 , G01N2201/127 , H04N5/2251
Abstract: A method for obtaining a point-of-collection, selected quantitative indicia of an analyte on a test strip using a smartphone involves imaging a test strip on which a colorimetric reaction of a target sample has occurred due to test strip illumination by the smartphone. The smartphone includes a smartphone app and a smartphone accessory that provides an external environment-independent/internal light-free, imaging environment independent of the smartphone platform being used. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later use, and communicated to a location where practitioners can provide additional review. Additionally, social media integration can allow for device results to be broadcast to specific audiences, to compare healthy living with others, to compete in health based games, create mappings, and other applications.
Abstract translation: 使用智能手机获得测试条上的分析物的收集点的选定定量标记的方法涉及对由于智能手机的测试条照明而在其上发生目标样品的比色反应的测试条进行成像。 智能手机包括智能手机应用程序和智能手机附件，可提供独立于所使用智能手机平台的外部环境独立/内部无光环境的成像环境。 然后可以将结果定量呈现或变成更为消费者友好的测量（正，负，高于平均水平等），显示给用户，存储供以后使用，并传达到从业者可以提供额外审查的位置。 此外，社交媒体整合可以允许将设备结果广播给特定的受众，将健康生活与他人进行比较，以竞争健康的游戏，创建映射和其他应用程序。
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5.发明授权公开(公告)号：US11668711B2
公开(公告)日：2023-06-06
申请号：US16763707
申请日：2018-11-13
Applicant: CORNELL UNIVERSITY
Inventor： Saurabh Mehta , David Erickson , Zhengda Lu
CPC classification number: G01N33/54388 , G01N21/6428 , G01N33/54386 , G01N33/582 , G01N33/6803 , G01N33/82 , G01N33/84 , G01N2021/6441 , G01N2333/4737 , G01N2333/705 , G01N2458/00 , G01N2470/04 , G01N2470/10
Abstract: A diagnostic assay strip includes a first layer that includes an iron mobile labelled specific binding partner that will bind to and iron biomarker from a sample and produce an iron complex and a vitamin A mobile labelled specific binding partner that will bind to a vitamin A biomarker from the sample and produce a vitamin A complex. A second layer includes iron and vitamin A test regions, and a control region. The iron test region has immobilized specific binding partners that will bind to the iron complex. The vitamin A test region has immobilized vitamin A biomarker that will bind to vitamin A mobile labelled specific binding partner, which is not bound to the vitamin A biomarker, passing from the first layer to the second layer. The control region has a moiety which will non-specifically bind to and immobilize the iron and vitamin A labelled specific binding partners. Methods of using the diagnostic assay strip are also discussed.
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Patent Agency Ranking
公开(公告)号：US10604733B2
公开(公告)日：2020-03-31
申请号：US15351715
申请日：2016-11-15
Applicant: CORNELL UNIVERSITY
Inventor： David Erickson , Perry M. Schein
Abstract: An optofluidic photoreactor including an optical waveguide having an input, characterized by an evanescent optical field confined along an outer surface of the optical waveguide produced by radiation propagating in the optical waveguide, means for inputting light to the input of the optical waveguide, and a photoactive material disposed substantially only within the evanescent field. A method for optically activating a photoactive material in an optofluidic photoreactor to convert carbon dioxide and water into other molecules that may be useful as a fuel or a chemical feedstock.
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7.发明授权公开(公告)号：US10168317B2
公开(公告)日：2019-01-01
申请号：US14406310
申请日：2013-06-10
Applicant: CORNELL UNIVERSITY
Inventor： Michael Mak , David Erickson
IPC: G01N33/50 , B01L3/00 , G01N33/574 , C12M3/06
Abstract: The present invention relates to a microfluidic device, a microfluidic system, and methods for tracking single cells, multiple cells, single cell lineages, and multiple cell lineages in series and/or in parallel. The microfluidic device comprises a substrate having one microfluidic channel formed therein or a plurality of microfluidic channels formed therein and arranged in parallel. The microfluidic system comprises: a microfluidic device according to the present invention; a cell loading reservoir in fluid communication with the inlet end of each microfluidic channel of the microfluidic device; and an outlet reservoir in fluid communication with the outlet end of each microfluidic channel of the microfluidic device. The present invention also relates to a high throughput microfluidic system and a kit for tracking single cells and/or single cell lineages.
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公开(公告)号：US09821314B2
公开(公告)日：2017-11-21
申请号：US14429407
申请日：2013-09-18
Applicant: CORNELL UNIVERSITY
Inventor： David Erickson , Li Jiang , Matthew Mancuso
CPC classification number: B01L7/52 , B01L3/5027 , B01L3/502715 , B01L7/5255 , B01L2300/0803 , B01L2300/0816 , B01L2300/12 , B01L2300/168 , B01L2300/1861 , C12Q1/686 , G01N2035/00158 , C12Q2565/629
Abstract: Disclosed are methods and apparatus for solar-thermal microfluidic polymerase chain reaction. A device comprises a microfluidic chip including at least one PCR region, an energy absorption layer disposed adjacent to the microfluidic chip, a solar energy concentrator adapted to produce a plurality of temperature profiles on the microfluidic chip adapted to facilitate PCR, and a photomask disposed between the solar energy concentrator and the microfluidic chip.
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公开(公告)号：US11186812B2
公开(公告)日：2021-11-30
申请号：US16832906
申请日：2020-03-27
Applicant: CORNELL UNIVERSITY
Inventor： David Erickson , Perry M. Schein
IPC: C12M1/00 , C12P7/04 , C12P7/06 , G02B6/00 , G02B6/26 , G02B6/293 , C12N1/20 , C10L1/02 , C12N1/12 , C12P7/24
Abstract: An optofluidic photoreactor including an optical waveguide having an input, characterized by an evanescent optical field confined along an outer surface of the optical waveguide produced by radiation propagating in the optical waveguide, means for inputting light to the input of the optical waveguide, and a photoactive material disposed substantially only within the evanescent field. A method for optically activating a photoactive material in an optofluidic photoreactor to convert carbon dioxide and water into other molecules that may be useful as a fuel or a chemical feedstock.
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公开(公告)号：US10241233B2
公开(公告)日：2019-03-26
申请号：US14824423
申请日：2015-08-12
Applicant: CORNELL UNIVERSITY
Inventor： David Erickson , Pilgyu Kang
Abstract: A method for characterizing an interaction between a first particle and a second particle is provided. The method includes the steps of: (i) providing an optical trap system including a photonics-based trap, a light source, and a camera; (ii) optically trapping, using the photonics-based trap, the first particle; (iii) obtaining a first measurement of a trap stiffness of the photonics-based trap; (iv) introducing the second particle to the optically trapped particle; (v) incubating the first and second particles under conditions suitable for an interaction between the first and second particles; (vi) obtaining a second measurement of the trap stiffness of the photonics-based trap after the incubation; and (vii) determining, using the first measurement of trap stiffness and the second measurement of trap stiffness, a property of the interaction between the first particle and the second particle.
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