公开(公告)号：US11668711B2

公开(公告)日：2023-06-06

申请号：US16763707

申请日：2018-11-13

Applicant: CORNELL UNIVERSITY

Inventor： Saurabh Mehta ,  David Erickson ,  Zhengda Lu

IPC: G01N33/543 ,  G01N21/64 ,  G01N33/58 ,  G01N33/68 ,  G01N33/82 ,  G01N33/84

CPC classification number: G01N33/54388 ,  G01N21/6428 ,  G01N33/54386 ,  G01N33/582 ,  G01N33/6803 ,  G01N33/82 ,  G01N33/84 ,  G01N2021/6441 ,  G01N2333/4737 ,  G01N2333/705 ,  G01N2458/00 ,  G01N2470/04 ,  G01N2470/10

Abstract: A diagnostic assay strip includes a first layer that includes an iron mobile labelled specific binding partner that will bind to and iron biomarker from a sample and produce an iron complex and a vitamin A mobile labelled specific binding partner that will bind to a vitamin A biomarker from the sample and produce a vitamin A complex. A second layer includes iron and vitamin A test regions, and a control region. The iron test region has immobilized specific binding partners that will bind to the iron complex. The vitamin A test region has immobilized vitamin A biomarker that will bind to vitamin A mobile labelled specific binding partner, which is not bound to the vitamin A biomarker, passing from the first layer to the second layer. The control region has a moiety which will non-specifically bind to and immobilize the iron and vitamin A labelled specific binding partners. Methods of using the diagnostic assay strip are also discussed.