公开(公告)号：US10214779B2

公开(公告)日：2019-02-26

申请号：US15694084

申请日：2017-09-01

Applicant: CSIR

Inventor： Jerolen Naidoo ,  Samantha Barichievy ,  Rethabile Khutlang ,  Musa M Mhlanga

IPC: C12Q1/6886 ,  C12N15/113 ,  A61K38/12 ,  A61K31/436 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/475 ,  A61K31/495 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/713 ,  A61K33/24 ,  C12Q1/70 ,  A61K31/197 ,  A61K31/4709 ,  A61K31/58 ,  A61K31/7072 ,  C12N15/11

Abstract: The present invention relates to methods for the identification of anti-HIV miRNAs and anti-HIV pharmaceutical compounds using high-throughput screening methods, comprising: transfecting reporter cells with a panel of miRNAs, infecting the reporter cells with HIV, screening the cells to identify miRNAs that modulate HIV infection and identifying the specific pathways, nucleic acids and/or polypeptides that are targeted by the miRNAs. The invention further provides for the identification and screening of anti-HIV pharmaceutical compounds having known activity against the specific pathways, nucleic acids and/or polypeptides that are targeted by the miRNAs for efficacy in the treatment of HIV. The invention also provides for the use of miRNA mimics, miRNA inhibitors and pharmaceutical compounds (including oncology drugs and kinase inhibitors) in the treatment and/or prevention of HIV infection.

公开(公告)号：US10351916B2

公开(公告)日：2019-07-16

申请号：US15962645

申请日：2018-04-25

Applicant: CSIR

Inventor： Jerolen Naidoo ,  Samantha Barichievy ,  Rethabile Khutlang ,  Musa M Mhlanga

IPC: A61K31/19 ,  C12Q1/6886 ,  C12N15/113 ,  A61K38/12 ,  A61K31/436 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/475 ,  A61K31/495 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/713 ,  A61K33/24 ,  C12Q1/70 ,  A61K31/197 ,  A61K31/4709 ,  A61K31/58 ,  A61K31/7072 ,  C12N15/11

Abstract: The present invention relates to methods for the identification of anti-HIV miRNAs and anti-HIV pharmaceutical compounds using high-throughput screening methods, comprising: transfecting reporter cells with a panel of miRNAs, infecting the reporter cells with HIV, screening the cells to identify miRNAs that modulate HIV infection and identifying the specific pathways, nucleic acids and/or polypeptides that are targeted by the miRNAs. The invention further provides for the identification and screening of anti-HIV pharmaceutical compounds having known activity against the specific pathways, nucleic acids and/or polypeptides that are targeted by the miRNAs for efficacy in the treatment of HIV. The invention also provides for the use of miRNA mimics, miRNA inhibitors and pharmaceutical compounds (including oncology drugs and kinase inhibitors) in the treatment and/or prevention of HIV infection.

公开(公告)号：US10143691B2

公开(公告)日：2018-12-04

申请号：US15503610

申请日：2015-08-17

Applicant: CSIR

Inventor： Janine Scholefield ,  Jerolen Naidoo ,  Musa M Mhlanga ,  Samantha Barichievy

IPC: A61K31/5025 ,  A61K38/17 ,  A61K31/277 ,  A61K31/497 ,  A61K31/496

Abstract: The present invention relates to methods and compositions for modulating the control of apoptosis, specifically for modulating the interaction between hnRNP-K and lincRNA-p21 to induce or prevent apoptosis in the cell.