公开(公告)号：US10167466B2

公开(公告)日：2019-01-01

申请号：US14916338

申请日：2014-09-04

Applicant: CSIR

Inventor： Stephanie Fanucchi ,  Youtaro Shibayama ,  Shaun Burd ,  Musa M. Mhlanga

IPC: C12N15/85 ,  C12N15/01 ,  C12N9/22 ,  C12N15/63 ,  C12Q1/6841 ,  C12Q1/6876

Abstract: This invention relates to a single cell assay for determining the effect of chromosomal contact on the transcriptional activity of genes of interest in a cell and to methods of silencing gene expression in a cell by way of perturbing gene regulatory elements which are engaged in chromosomal contact.