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    In-situ heated disposition of parylene to enhance pore penetration into silicone
    1.
    发明授权
    In-situ heated disposition of parylene to enhance pore penetration into silicone 有权

    公开(公告)号：US10287451B2

    公开(公告)日：2019-05-14

    申请号：US15276328

    申请日：2016-09-26

    Applicant: California Institute of Technology

    Inventor： Yu-Chong Tai ,  Dongyang Kang

    IPC: B32B19/00 ,  C09D165/04 ,  B05D1/00 ,  C03C17/32

    Abstract: A composition of matter is described in which a porous material, such as polydimethylsiloxane (PDMS), is coated with parylene N, C, D, or AF-4 by vapor deposition polymerization while a temperature of the porous material's surface being coated is heated to between 60° C. and 120° C., or 80° C. and 85° C., during deposition. The parylene forms nano roots within the porous material that connect with a conformal surface coating of parylene. In some embodiments, a watertight separation chamber in an integrated microfluidic liquid chromatography device is fabricated by heating tunnels in micro-fabricated PDMS and depositing parylene within the heated tunnels.

    RELIABLE DEPOSITION OF THIN PARYLENE
    2.
    发明申请
    RELIABLE DEPOSITION OF THIN PARYLENE 审中-公开

    公开(公告)号：US20170113246A1

    公开(公告)日：2017-04-27

    申请号：US15331544

    申请日：2016-10-21

    Applicant: California Institute of Technology

    Inventor： Yu-Chong Tai ,  Wei Wang ,  Dongyang Kang

    IPC: B05D1/00 ,  B05D3/04 ,  B81C1/00

    CPC classification number: B05D1/60 ,  B05D3/0486 ,  B05D3/0493 ,  B81C1/00674 ,  C23C16/45559

    Abstract: Apparatus, system, and method of depositing thin and ultra-thin parylene are described. In an example, a core deposition chamber is used. The core deposition chamber includes a base and a rigid, removable cover configured to mate and seal with the base to create the core deposition chamber and to define an inside and an outside of the core deposition chamber. The core deposition chamber also includes a conduit through a top of the cover. The conduit has a lumen connecting the inside to the outside of the core deposition chamber. The lumen has a length and a cross-section. The cross-section has a width between 50 μm and 6000 μm. The length is less than 140 times the cross-section width. The core deposition chamber can be placed in an outer deposition chamber and can achieve parylene deposition less than 1 μm thick inside the core deposition chamber.

    In-situ heated deposition of parylene to enhance pore penetration into silicone
    3.
    发明授权
    In-situ heated deposition of parylene to enhance pore penetration into silicone 有权
    聚对二甲苯的原位加热沉积以增强孔中的渗透性

    公开(公告)号：US09469778B2

    公开(公告)日：2016-10-18

    申请号：US14509226

    申请日：2014-10-08

    Applicant: California Institute of Technology

    Inventor： Yu-Chong Tai ,  Dongyang Kang

    IPC: C23C16/00 ,  C09D165/04 ,  B05D1/00

    CPC classification number: C09D165/04 ,  B05D1/60 ,  C03C17/328 ,  C03C2217/20 ,  C03C2217/76 ,  C03C2218/152 ,  C08G2261/3424 ,  C08G2261/65 ,  Y10T428/249958

    Abstract: Coating porous material, such as PDMS, with parylene N, C, D, and AF-4 by vapor deposition polymerization is described in which a temperature of the porous material's surface being coated is heated to between 60° C. and 120° C., or 80° C. and 85° C., during deposition. The parylene forms nano roots within the porous material that connect with a conformal surface coating of parylene. In some embodiments, a watertight separation chamber in an integrated microfluidic liquid chromatography device is fabricated by heating tunnels in micro-fabricated PDMS and depositing parylene within the heated tunnels.

    Abstract translation: 描述了通过气相沉积聚合将聚对二甲苯N，C，D和AF-4等多孔材料涂覆在多孔材料中，其中被覆多孔材料的表面的温度被加热至60℃至120℃。 ，或80℃和85℃。 聚对二甲苯形成多孔材料内的纳米根，其与聚对二甲苯的共形表面涂层连接。 在一些实施方案中，集成的微流体液相色谱装置中的水密分离室通过在微制造的PDMS中加热隧道并在加热的隧道内沉积聚对二甲苯来制造。

    IN-SITU HEATED DEPOSITION OF PARYLENE TO ENHANCE PORE PENETRATION INTO SILICONE
    4.
    发明申请
    IN-SITU HEATED DEPOSITION OF PARYLENE TO ENHANCE PORE PENETRATION INTO SILICONE 有权
    加速渗透沉淀到硅胶中的原位加热沉淀

    公开(公告)号：US20150111023A1

    公开(公告)日：2015-04-23

    申请号：US14509226

    申请日：2014-10-08

    Applicant: California Institute of Technology

    Inventor： Yu-Chong Tai ,  Dongyang Kang

    IPC: C09D165/04 ,  B05D1/02 ,  B05D3/02

    CPC classification number: C09D165/04 ,  B05D1/60 ,  C03C17/328 ,  C03C2217/20 ,  C03C2217/76 ,  C03C2218/152 ,  C08G2261/3424 ,  C08G2261/65 ,  Y10T428/249958

    Abstract: Coating porous material, such as PDMS, with parylene N, C, D, and AF-4 by vapor deposition polymerization is described in which a temperature of the porous material's surface being coated is heated to between 60° C. and 120° C., or 80° C. and 85° C., during deposition. The parylene forms nano roots within the porous material that connect with a conformal surface coating of parylene. In some embodiments, a watertight separation chamber in an integrated microfluidic liquid chromatography device is fabricated by heating tunnels in micro-fabricated PDMS and depositing parylene within the heated tunnels.

    Abstract translation: 描述了通过气相沉积聚合将聚对二甲苯N，C，D和AF-4等多孔材料涂覆在多孔材料中，其中被覆多孔材料的表面的温度被加热至60℃至120℃。 ，或80℃和85℃。 聚对二甲苯形成多孔材料内的纳米根，其与聚对二甲苯的共形表面涂层连接。 在一些实施方案中，集成的微流体液相色谱装置中的水密分离室通过在微制造的PDMS中加热隧道并在加热的隧道内沉积聚对二甲苯来制造。

    Reliable deposition of thin parylene
    6.
    发明授权
    Reliable deposition of thin parylene 有权

    公开(公告)号：US11077462B2

    公开(公告)日：2021-08-03

    申请号：US15331544

    申请日：2016-10-21

    Applicant: California Institute of Technology

    Inventor： Yu-Chong Tai ,  Wei Wang ,  Dongyang Kang

    IPC: B05D1/00 ,  B05D3/04 ,  B81C1/00 ,  C23C16/455

    Abstract: Apparatus, system, and method of depositing thin and ultra-thin parylene are described. In an example, a core deposition chamber is used. The core deposition chamber includes a base and a rigid, removable cover configured to mate and seal with the base to create the core deposition chamber and to define an inside and an outside of the core deposition chamber. The core deposition chamber also includes a conduit through a top of the cover. The conduit has a lumen connecting the inside to the outside of the core deposition chamber. The lumen has a length and a cross-section. The cross-section has a width between 50 μm and 6000 μm. The length is less than 140 times the cross-section width. The core deposition chamber can be placed in an outer deposition chamber and can achieve parylene deposition less than 1 μm thick inside the core deposition chamber.

    Implantable device for retaining live cells and providing nutrients thereto
    7.
    发明授权
    Implantable device for retaining live cells and providing nutrients thereto 有权

    公开(公告)号：US10092387B2

    公开(公告)日：2018-10-09

    申请号：US15274229

    申请日：2016-09-23

    Applicant: California Institute of Technology ,  City of Hope

    Inventor： Yu-Chong Tai ,  Dongyang Kang ,  Hirotake Komatsu ,  Henry K. Lin ,  Yoko Mullen

    IPC: A61F2/02 ,  C12M1/00

    Abstract: An implantable medical device, a method of manufacturing, and a method of use are described. The implantable medical device includes an absorption bag connected by a cannula to a discharge bag. The implantable medical device also includes a reservoir external to the discharge bag and attached to a surface of the discharge bag. At least a portion of the absorption bag and at least a portion of a bottom surface of the reservoir are permeable to a predefined class of small molecules, such as molecular oxygen. The reservoir can retain live cells that rely on the small molecules for survival and growth. Based on concentration of the small molecules, the small molecules permeate into the absorption bag and are transported to the discharge bag for permeation into the reservoir, thereby providing a supply of the small molecules to the live cells.

    IN-SITU HEATED DEPOSITION OF PARYLENE TO ENHANCE PORE PENETRATION INTO SILICONE
    8.
    发明申请
    IN-SITU HEATED DEPOSITION OF PARYLENE TO ENHANCE PORE PENETRATION INTO SILICONE 审中-公开
    加速渗透沉淀到硅胶中的原位加热沉淀

    公开(公告)号：US20170009097A1

    公开(公告)日：2017-01-12

    申请号：US15276328

    申请日：2016-09-26

    Applicant: California Institute of Technology

    Inventor： Yu-Chong Tai ,  Dongyang Kang

    IPC: C09D165/04 ,  B05D1/00 ,  C03C17/32

    CPC classification number: C09D165/04 ,  B05D1/60 ,  C03C17/328 ,  C03C2217/20 ,  C03C2217/76 ,  C03C2218/152 ,  C08G2261/3424 ,  C08G2261/65 ,  Y10T428/249958

    Abstract: A composition of matter is described in which a porous material, such as polydimethylsiloxane (PDMS), is coated with parylene N, C, D, or AF-4 by vapor deposition polymerization while a temperature of the porous material's surface being coated is heated to between 60° C. and 120° C., or 80° C. and 85° C., during deposition. The parylene forms nano roots within the porous material that connect with a conformal surface coating of parylene. In some embodiments, a watertight separation chamber in an integrated microfluidic liquid chromatography device is fabricated by heating tunnels in micro-fabricated PDMS and depositing parylene within the heated tunnels.

    Abstract translation: 描述了一种物质组合物，其中诸如聚二甲基硅氧烷（PDMS）的多孔材料通过气相沉积聚合被聚对二甲苯N，C，D或AF-4涂覆，同时将多孔材料被涂覆的表面的温度加热到 在60℃至120℃，或80℃和85℃之间。 聚对二甲苯形成多孔材料内的纳米根，其与聚对二甲苯的共形表面涂层连接。 在一些实施方案中，集成的微流体液相色谱装置中的水密分离室通过在微制造的PDMS中加热隧道并在加热的隧道内沉积聚对二甲苯来制造。

    IMPLANTABLE DEVICE FOR RETAINING LIVE CELLS AND PROVIDING NUTRIENTS THERETO
    10.
    发明申请
    IMPLANTABLE DEVICE FOR RETAINING LIVE CELLS AND PROVIDING NUTRIENTS THERETO 审中-公开

    公开(公告)号：US20170086963A1

    公开(公告)日：2017-03-30

    申请号：US15274229

    申请日：2016-09-23

    Applicant: California Institute of Technology ,  City of Hope

    Inventor： Yu-Chong Tai ,  Dongyang Kang ,  Hirotake Komatsu ,  Henry K. Lin ,  Yoko Mullen

    IPC: A61F2/02

    CPC classification number: A61F2/022 ,  A61F2240/004 ,  C12M21/00

    Abstract: An implantable medical device, a method of manufacturing, and a method of use are described. The implantable medical device includes an absorption bag connected by a cannula to a discharge bag. The implantable medical device also includes a reservoir external to the discharge bag and attached to a surface of the discharge bag. At least a portion of the absorption bag and at least a portion of a bottom surface of the reservoir are permeable to a predefined class of small molecules, such as molecular oxygen. The reservoir can retain live cells that rely on the small molecules for survival and growth. Based on concentration of the small molecules, the small molecules permeate into the absorption bag and are transported to the discharge bag for permeation into the reservoir, thereby providing a supply of the small molecules to the live cells.

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