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公开(公告)号：US12297230B2
公开(公告)日：2025-05-13
申请号：US18316102
申请日：2023-05-11
Applicant: California Institute of Technology
Inventor： Lucy S. Chong , Ronghui Zhu , Xiaofei Ge , Michael B. Elowitz , Mark W. Budde
Abstract: Disclosed herein include methods, compositions, and kits suitable for use in thresholding of protein signals. There are provided, in some embodiments, synthetic protein circuits that respond to inputs only above or below a certain threshold concentration. In some embodiments, the threshold value itself is tunable. Methods of treating a disease or disorder characterized by aberrant signaling are provided in some embodiments.
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公开(公告)号：US11667676B2
公开(公告)日：2023-06-06
申请号：US16738664
申请日：2020-01-09
Applicant: California Institute of Technology
Inventor： Lucy S. Chong , Ronghui Zhu , Xiaofei Ge , Michael B. Elowitz , Mark W. Budde
CPC classification number: C07K14/001 , C12N9/22
Abstract: Disclosed herein include methods, compositions, and kits suitable for use in thresholding of protein signals. There are provided, in some embodiments, synthetic protein circuits that respond to inputs only above or below a certain threshold concentration. In some embodiments, the threshold value itself is tunable. Methods of treating a disease or disorder characterized by aberrant signaling are provided in some embodiments.
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公开(公告)号：US20240101606A1
公开(公告)日：2024-03-28
申请号：US18316102
申请日：2023-05-11
Applicant: California Institute of Technology
Inventor： Lucy S. Chong , Ronghui Zhu , Xiaofei Ge , Michael B. Elowitz , Mark W. Budde
CPC classification number: C07K14/001 , C12N9/22
Abstract: Disclosed herein include methods, compositions, and kits suitable for use in thresholding of protein signals. There are provided, in some embodiments, synthetic protein circuits that respond to inputs only above or below a certain threshold concentration. In some embodiments, the threshold value itself is tunable. Methods of treating a disease or disorder characterized by aberrant signaling are provided in some embodiments.
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公开(公告)号：US20200277333A1
公开(公告)日：2020-09-03
申请号：US16738664
申请日：2020-01-09
Applicant: California Institute of Technology
Inventor： Lucy S. Chong , Ronghui Zhu , Xiaofei Ge , Michael B. Elowitz , Mark W. Budde
Abstract: Disclosed herein include methods, compositions, and kits suitable for use in thresholding of protein signals. There are provided, in some embodiments, synthetic protein circuits that respond to inputs only above or below a certain threshold concentration. In some embodiments, the threshold value itself is tunable. Methods of treating a disease or disorder characterized by aberrant signaling are provided in some embodiments.
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