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公开(公告)号：US20180240658A1
公开(公告)日：2018-08-23
申请号：US15750550
申请日：2016-08-09
Applicant: DH Technologies Development Pte. Ltd.
Inventor： David Michael Cox , Gordana Ivosev
CPC classification number: H01J49/0031 , H01J49/0027 , H01J49/004 , H01J49/0045 , H01J49/04 , H01J49/26
Abstract: An m/z range of an ion beam is divided into two or more precursor ion mass selection windows. A pattern of two or more different window m/z ranges to be used during two or more successive cycles for at least one precursor ion mass selection window is determined. The pattern includes an initial window m/z range and one or more successively different window m/z ranges. Each of the one or more successively different window m/z ranges includes at least a portion of the initial window m/z range. A tandem mass spectrometer is instructed to select and fragment the two or more precursor ion mass selection windows during each cycle of a plurality of cycles and to repeatedly use the pattern for each group of two or more successive cycles of the plurality of cycles for the selection and fragmentation of the at least one precursor ion mass selection window.
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公开(公告)号：US10825668B2
公开(公告)日：2020-11-03
申请号：US15750557
申请日：2016-08-09
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Lyle Lorrence Burton , David Michael Cox
IPC: H01J49/00
Abstract: One or more known compounds of a sample are ionized using an ion source, producing an ion beam of precursor ions. A tandem mass spectrometer receives the ion beam from the ion source, selects one or more precursor ions from the ion beam using a precursor ion mass selection window, fragments precursor ions within the precursor ion mass selection window, and mass analyzes the resulting product ions, producing an unknown product ion mass spectrum. A library product ion mass spectrum for a known compound is retrieved from a memory. Each peak of the unknown spectrum is analyzed for a potential non-halogen isotopic peak using a processor, and if a potential non-halogen isotopic peak is found, it is removed if it does not have a corresponding peak in the library spectrum.
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公开(公告)号：US10163613B2
公开(公告)日：2018-12-25
申请号：US15750550
申请日：2016-08-09
Applicant: DH Technologies Development Pte. Ltd.
Inventor： David Michael Cox , Gordana Ivosev
Abstract: An m/z range of an ion beam is divided into two or more precursor ion mass selection windows. A pattern of two or more different window m/z ranges to be used during two or more successive cycles for at least one precursor ion mass selection window is determined. The pattern includes an initial window m/z range and one or more successively different window m/z ranges. Each of the one or more successively different window m/z ranges includes at least a portion of the initial window m/z range. A tandem mass spectrometer is instructed to select and fragment the two or more precursor ion mass selection windows during each cycle of a plurality of cycles and to repeatedly use the pattern for each group of two or more successive cycles of the plurality of cycles for the selection and fragmentation of the at least one precursor ion mass selection window.
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公开(公告)号：US09620342B2
公开(公告)日：2017-04-11
申请号：US14443936
申请日：2013-11-21
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： David Michael Cox
CPC classification number: H01J49/0036 , H01J49/0031 , H01J49/004 , H01J49/26
Abstract: Systems and methods are provided for interlacing ramped mass spectrometer parameter values during data acquisition. Ions from a sample are acquired within a cycle time, Ct, using a mass spectrometer. Within each Ct, two or more scans of the acquired ions are performed using two or more ramped values for a parameter of the mass spectrometer. When it is determined that scans for a desired range of ramped parameter values cannot be performed within Ct, the desired range of ramped values is divided into at least two interlaced groups of ramped values. The mass spectrometer is instructed to perform scans for each of the interlaced groups within two or more cycle times. Spectra from the scans for each of the at least two interlaced groups are combined. The ramped parameter values of the combined spectra have the desired range and the desired effective step size.
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公开(公告)号：US20220341898A1
公开(公告)日：2022-10-27
申请号：US17753034
申请日：2020-08-14
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： David Michael Cox , Yves Le Blanc
IPC: G01N30/86
Abstract: An operational condition of a liquid chromatography (LC) system (2110) is detected and displayed without user intervention. A plurality of pressure measurements over time are received from a pressure sensor (2119) of the LC system. A processor (2140) calculates values from the measurements for six parameters including a beginning pressure (PB), an ending pressure (PE), an average pressure (T1) for a first half of the separation, an average pressure (T2) for a second half of the separation, a ratio T1/PB, and a ratio T2/PB. The values of the six parameters are classified as one of one or more operational conditions of the LC system using a machine learning model. The machine learning model is created from values of the six parameters calculated from known separations for each of the one or more operational conditions. The operational condition found from the classification is displayed on a display device (2141).
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Patent Agency Ranking
公开(公告)号：US09548190B2
公开(公告)日：2017-01-17
申请号：US14443930
申请日：2013-11-21
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： John Lawrence Campbell , David Michael Cox
CPC classification number: H01J49/0081 , H01J49/0036 , H01J49/004 , H01J49/022
Abstract: Systems and methods are provided for scheduled MS3. A compound of interest is separated from a sample over a known time period using a separation device. A plurality of sMRM experiments are performed over the known time period on the separating compound of interest using a mass spectrometer. An intensity of a product ion of the compound of interest is produced for each of the plurality of sMRM experiments. Each intensity for the product ion for each of the plurality of sMRM experiments is compared to a threshold intensity level using a processor. When an intensity for the product ion of an sMRM experiment of the plurality of sMRM experiments is equal to or exceeds the threshold intensity level, the mass spectrometer is instructed to perform one or more MS3 experiments for the product ion using the processor.
Abstract translation: 为计划的MS3提供系统和方法。 使用分离装置在已知时间段内将样品化合物与样品分离。 使用质谱仪在目标分离化合物上在已知时间段内进行多个sMRM实验。 对于多个sMRM实验中的每一个产生感兴趣的化合物的产物离子的强度。 将多个sMRM实验中的每一个的产物离子的每个强度与使用处理器的阈值强度水平进行比较。 当多个sMRM实验的sMRM实验的产物离子的强度等于或超过阈值强度水平时，指示质谱仪使用处理器对产物离子进行一个或多个MS 3实验。
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公开(公告)号：US20150318154A1
公开(公告)日：2015-11-05
申请号：US14443930
申请日：2013-11-21
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： John Lawrence Campbell , David Michael Cox
CPC classification number: H01J49/0081 , H01J49/0036 , H01J49/004 , H01J49/022
Abstract: Systems and methods are provided for scheduled MS3. A compound of interest is separated from a sample over a known time period using a separation device. A plurality of sMRM experiments are performed over the known time period on the separating compound of interest using a mass spectrometer. An intensity of a product ion of the compound of interest is produced for each of the plurality of sMRM experiments. Each intensity for the product ion for each of the plurality of sMRM experiments is compared to a threshold intensity level using a processor. When an intensity for the product ion of an sMRM experiment of the plurality of sMRM experiments is equal to or exceeds the threshold intensity level, the mass spectrometer is instructed to perform one or more MS3 experiments for the product ion using the processor.
Abstract translation: 为计划的MS3提供系统和方法。 使用分离装置在已知时间段内将样品化合物与样品分离。 使用质谱仪在目标分离化合物上在已知时间段内进行多个sMRM实验。 对于多个sMRM实验中的每一个产生感兴趣的化合物的产物离子的强度。 将多个sMRM实验中的每一个的产物离子的每个强度与使用处理器的阈值强度水平进行比较。 当多个sMRM实验的sMRM实验的产物离子的强度等于或超过阈值强度水平时，指示质谱仪使用处理器对产物离子进行一个或多个MS 3实验。
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公开(公告)号：US20220199390A1
公开(公告)日：2022-06-23
申请号：US17310959
申请日：2020-04-15
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： David Michael Cox , Nic G. Bloomfield
Abstract: The resolution of a TOF mass analyzer is maintained despite a loss of resolution in one or more channels of a multichannel ion detection system by selecting the highest resolution channels for qualitative analysis. Ion packets that impact a multichannel detector are converted into multiplied electrons and emitted from two or more segmented electrodes that correspond to impacts in different regions across a length of the detector. The electrons received by each electrode of the two or more segmented electrodes for each ion packet are converted into digital values in a channel of a multichannel digitizer, producing digital values for at least two or more channels Qualitative information about the ion packets is calculated using digital values of a predetermined subset of one or more channels of the at least two or more channels known to provide the highest resolution.
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公开(公告)号：US10446376B2
公开(公告)日：2019-10-15
申请号：US14443935
申请日：2013-11-21
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： David Michael Cox
IPC: H01J49/00
Abstract: Systems and methods are provided for compound identification using multiple spectra that are a function of a variable instrument parameter that affects the intensity of fragment ions. A plurality of acquired fragment ion spectra that are a function of a variable instrument parameter for at least one ion are received from a mass spectrometer using a processor. The at least one ion is identified by comparing rates of change of mass intensity, with respect to the variable instrument parameter, for acquired and known fragment ions using the processor. Specifically, one or more acquired rates of change calculated for acquired fragment ions from the plurality of acquired fragment ion spectra are compared with one or more known rates of change calculated for one or more stored fragment ions of one or more known compounds in a database of known compounds.
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公开(公告)号：US20150311051A1
公开(公告)日：2015-10-29
申请号：US14443936
申请日：2013-11-21
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： David Michael Cox
CPC classification number: H01J49/0036 , H01J49/0031 , H01J49/004 , H01J49/26
Abstract: Systems and methods are provided for interlacing ramped mass spectrometer parameter values during data acquisition. Ions from a sample are acquired within a cycle time, Ct, using a mass spectrometer. Within each Ct, two or more scans of the acquired ions are performed using two or more ramped values for a parameter of the mass spectrometer. When it is determined that scans for a desired range of ramped parameter values cannot be performed within Ct, the desired range of ramped values is divided into at least two interlaced groups of ramped values. The mass spectrometer is instructed to perform scans for each of the interlaced groups within two or more cycle times. Spectra from the scans for each of the at least two interlaced groups are combined. The ramped parameter values of the combined spectra have the desired range and the desired effective step size.
Abstract translation: 提供了系统和方法，用于在数据采集期间交错斜坡质谱仪参数值。 使用质谱仪在一个循环时间Ct内获取样品的离子。 在每个Ct中，对于质谱仪的参数使用两个或多个斜坡值来执行所获取的离子的两次或更多次扫描。 当确定对于期望范围的斜坡参数值的扫描不能在Ct内执行时，希望的斜坡值的范围被划分成至少两个斜坡值的隔行组。 指示质谱仪在两个或多个循环时间内对每个隔行扫描组进行扫描。 对来自至少两个隔行组中的每一个的扫描的光谱进行组合。 组合光谱的斜率参数值具有期望的范围和期望的有效步长。
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