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1.发明申请公开(公告)号：US20140357502A1
公开(公告)日：2014-12-04
申请号：US14365983
申请日：2012-11-28
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD
Inventor： John Lawrence Campbell , Yves Le Blanc , Alexandre V. Loboda , Igor Chernushevich
IPC: G06F19/00
CPC classification number: G06F19/703 , H01J49/0031 , H01J49/004
Abstract: In a first location of a mass spectrometer, a plurality of ionized molecules of an ion source are selected that have mass-to-charge ratios within a mass-to-charge ratio window width. The plurality of selected ionized molecules are transmitted from a first to a second location. Reagent ions are transmitted to the second location to reduce a charge state of one or more of the plurality of selected ionized molecules. A mass analyzer is used to analyze the plurality of reduced ionized molecules and produce a mass spectrum. A compound is identified from a peak of the spectrum that has a mass-to-charge ratio less than or equal to the highest mass-to-charge ratio in the window width if the noise is multiply charged and greater than the highest mass-to-charge ratio in the window width if the noise is singly charged.
Abstract translation: 在质谱仪的第一位置，选择离子源的多个离子化分子，其具有在质荷比窗口宽度之内的质荷比。 多个选择的电离分子从第一位置传递到第二位置。 试剂离子被传递到第二位置以减少多个选定的电离分子中的一个或多个的电荷状态。 质量分析器用于分析多个还原离子化分子并产生质谱。 如果噪声是多次充电并且大于最高质量 - 到达的质量 - 荷电比，如果光谱的峰值具有小于或等于窗口宽度中的最高质荷比的化合物， 如果噪声被单独充电，则窗口宽度的充电比例。
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公开(公告)号：US20160148791A1
公开(公告)日：2016-05-26
申请号：US15008385
申请日：2016-01-27
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Nic G. Bloomfield , Alexandre V. Loboda
CPC classification number: H01J49/0009 , H01J49/0036 , H01J49/025 , H01J49/40
Abstract: Systems and methods are provided for correcting uniform detector saturation of a mass analyzer using a calibration curve. In one method, a measured spectrum is received from a mass analyzer that includes a detector and an analog-to-digital converter (ADC) detector subsystem and that analyzes a beam of ions produced by an ion source that ionizes molecules of a sample using a processor. A total ion value of the measured spectrum is calculated by summing intensities of ions in the measured spectrum using the processor. A correction factor is determined by comparing the total ion value to a stored calibration curve that provides correction factors as a function of total ion values using the processor. Intensities of the measured spectrum are multiplied by the determined correction factor producing a corrected measured spectrum using the processor.
Abstract translation: 提供了使用校准曲线校正质量分析器的均匀检测器饱和度的系统和方法。 在一种方法中，从包括检测器和模拟 - 数字转换器（ADC）检测器子系统的质量分析器接收测量的光谱，并且分析由离子源产生的离子束，其使用离子源离子化样品的分子 处理器。 通过使用处理器对所测量的光谱中的离子的强度求和来计算测量光谱的总离子值。 通过将总离子值与存储的校准曲线进行比较来确定校正因子，该校准曲线使用处理器提供作为总离子值的函数的校正因子。 测量光谱的强度乘以确定的校正因子，使用处理器产生校正的测量光谱。
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公开(公告)号：US20160209361A1
公开(公告)日：2016-07-21
申请号：US14907450
申请日：2014-08-07
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Nic G. Bloomfield , Alexandre V. Loboda , Igor Chernushevich
CPC classification number: G01N27/62 , G16C20/20 , H01J49/0036 , H01J49/40 , H01J49/4225
Abstract: Systems and methods are provided for calculating and storing an average amplitude response for each peak of a mass spectrum during data acquisition. A mass analyzer is instructed to analyze N extractions of an ion beam, producing N sub-spectra. For each sub-spectrum of the N sub-spectra, a nonzero amplitude from an ADC detector subsystem is counted as one ion, producing a count of one for each ion. The ADC amplitudes and counts of the N sub-spectra are summed, producing a spectrum that includes a summed ADC amplitude and a total count for each ion. For each ion of the spectrum, an estimated ion count is calculated from a Poisson distribution of the total count of each ion for the N sub-spectra. For each ion of the spectrum, an average amplitude response is calculated by dividing the summed amplitude by the estimated ion count and stored.
Abstract translation: 提供了用于在数据采集期间计算和存储质谱的每个峰值的平均振幅响应的系统和方法。 指示质量分析仪分析离子束的N次提取，产生N个子光谱。 对于N个子光谱的每个子光谱，来自ADC检测器子系统的非零幅度被计为一个离子，为每个离子产生一个计数。 将N个子谱的ADC幅度和计数相加，产生包括ADC的幅度和每个离子的总计数的谱。 对于光谱的每个离子，从N个子光谱的每个离子的总计数的泊松分布计算估计的离子计数。 对于频谱的每个离子，通过将总和振幅除以估计的离子计数并存储来计算平均振幅响应。
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4.发明授权公开(公告)号：US09390238B2
公开(公告)日：2016-07-12
申请号：US14365983
申请日：2012-11-28
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： John Lawrence Campbell , Yves Le Blanc , Alexandre V. Loboda , Igor Chernushevich
CPC classification number: G06F19/703 , H01J49/0031 , H01J49/004
Abstract: In a first location of a mass spectrometer, a plurality of ionized molecules of an ion source are selected that have mass-to-charge ratios within a mass-to-charge ratio window width. The plurality of selected ionized molecules are transmitted from a first to a second location. Reagent ions are transmitted to the second location to reduce a charge state of one or more of the plurality of selected ionized molecules. A mass analyzer is used to analyze the plurality of reduced ionized molecules and produce a mass spectrum. A compound is identified from a peak of the spectrum that has a mass-to-charge ratio less than or equal to the highest mass-to-charge ratio in the window width if the noise is multiply charged and greater than the highest mass-to-charge ratio in the window width if the noise is singly charged.
Abstract translation: 在质谱仪的第一位置，选择离子源的多个离子化分子，其具有在质荷比窗口宽度之内的质荷比。 多个选择的电离分子从第一位置传递到第二位置。 试剂离子被传递到第二位置以减少多个选定的电离分子中的一个或多个的电荷状态。 质量分析器用于分析多个还原离子化分子并产生质谱。 如果噪声是多次充电并且大于最高质量 - 到达的质量 - 荷电比，如果光谱的峰值具有小于或等于窗口宽度中的最高质荷比的化合物， 如果噪声被单独充电，则窗口宽度的充电比例。
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公开(公告)号：US20160189943A1
公开(公告)日：2016-06-30
申请号：US14907447
申请日：2014-08-07
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Nic G. Bloomfield , Alexandre V. Loboda
CPC classification number: H01J49/0009 , H01J49/0036 , H01J49/025 , H01J49/40
Abstract: Systems and methods are provided for correcting uniform detector saturation. In one method, a mass analyzer analyzes N extractions of an ion beam. A nonzero amplitude from an ADC detector subsystem is counted as one ion, producing a count of one for each ion of each sub-spectrum. The ADC amplitudes and counts of the N sub-spectra are summed, producing a spectrum that includes a summed ADC amplitude and a total count for each ion of the spectrum. A probability that the total count arises from single ions hitting the detector is calculated. For each ion of the spectrum where the probability exceeds a threshold value, an amplitude response is calculated, producing amplitude responses for ions found to be single ions hitting the detector. Amplitude responses are combined, producing a combined amplitude response. The total count is dynamically corrected using the combined amplitude response and the summed ADC amplitude.
Abstract translation: 提供了系统和方法来校正均匀的检测器饱和度。 在一种方法中，质量分析器分析离子束的N次提取。 来自ADC检测器子系统的非零幅度被计为一个离子，为每个子光谱的每个离子产生一个计数。 将N个子光谱的ADC幅度和计数相加，产生包括每个光谱离子的ADC幅度和总计数的谱的频谱。 计算总计数来自单个离子撞击检测器的概率。 对于概率超过阈值的频谱的每个离子，计算振幅响应，产生发现是单个离子撞击检测器的离子的振幅响应。 振幅响应被组合，产生组合振幅响应。 使用组合幅度响应和总和的ADC幅度动态校正总计数。
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Patent Agency Ranking
公开(公告)号：US09230790B2
公开(公告)日：2016-01-05
申请号：US14369932
申请日：2012-11-28
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Alexandre V. Loboda
CPC classification number: H01J49/066 , H01J49/26
Abstract: Systems and related methods are disclosed herein that generally involve focusing dispersed ions using one or more DC ion funnels. In some embodiments, a DC ion funnel is provided that includes a plurality of ring-shaped electrodes, each having an aperture formed therein such that the funnel defines an interior volume extending between an ion inlet and an ion outlet. A controller applies a DC potential to each of the electrodes without applying an RF potential to any of the electrodes, such that ions entering the funnel are substantially confined within said volume. The interior volume can have any of a variety of shapes, such as cylindrical, frusto-conical, and curved frusto-conical. In addition, any of a variety of DC potentials can be applied to the plurality of electrodes.
Abstract translation: 本文公开的系统和相关方法通常涉及使用一个或多个DC离子漏斗聚焦分散的离子。 在一些实施例中，提供了DC离子漏斗，其包括多个环形电极，每个电极具有形成在其中的孔，使得漏斗限定在离子入口和离子出口之间延伸的内部容积。 控制器将DC电位施加到每个电极，而不对任何电极施加RF电势，使得进入漏斗的离子基本上被限制在所述体积内。 内部容积可以具有各种形状，例如圆柱形，截头圆锥形和弯曲的截头圆锥形。 此外，可以对多个电极施加各种DC电位中的任何一个。
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公开(公告)号：US09147567B2
公开(公告)日：2015-09-29
申请号：US14375489
申请日：2013-02-01
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Alexandre V. Loboda
CPC classification number: H01J49/063 , H01J49/10 , H01J49/24 , H01J49/36 , H01J49/4255
Abstract: An ion source and an ion guide chamber are provided. The ion guide chamber having a gas flow, the gas flow having a longitudinal velocity and a transverse velocity. The ion guide chamber having an exit aperture and at least one ion guide. The at least one ion guide having an entrance end and an exit end with an exit cross-section wherein the exit cross-section is sized to be smaller in area than the entrance cross-section. The at least one ion guide having a plurality of elongated electrodes wherein a gap between the elongated electrodes and the shape of the elongated electrodes in the vicinity of the gap are essentially the same along the length of the at least one ion guide for confining the ions in the vicinity of the gap by a combination of the transverse velocity of the gas and the RF voltage.
Abstract translation: 提供离子源和离子导向室。 离子导向室具有气流，气流具有纵向速度和横向速度。 离子导向室具有出口孔和至少一个离子导向件。 所述至少一个离子导向器具有入口端和具有出口横截面的出口端，其中所述出口横截面的尺寸设定成比所述入口横截面更小的面积。 所述至少一个离子导向器具有多个细长电极，其中细长电极之间的间隙和间隙附近的细长电极的形状沿着至少一个离子导向器的长度基本相同，用于限制离子 通过气体的横向速度和RF电压的组合在间隙附近。
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公开(公告)号：US20150008320A1
公开(公告)日：2015-01-08
申请号：US14375489
申请日：2013-02-01
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Alexandre V. Loboda
CPC classification number: H01J49/063 , H01J49/10 , H01J49/24 , H01J49/36 , H01J49/4255
Abstract: An ion source and an ion guide chamber are provided. The ion guide chamber having a gas flow, the gas flow having a longitudinal velocity and a transverse velocity. The ion guide chamber having an exit aperture and at least one ion guide. The at least one ion guide having an entrance end and an exit end with an exit cross-section wherein the exit cross-section is sized to be smaller in area than the entrance cross-section. The at least one ion guide having a plurality of elongated electrodes wherein a gap between the elongated electrodes and the shape of the elongated electrodes in the vicinity of the gap are essentially the same along the length of the at least one ion guide for confining the ions in the vicinity of the gap by a combination of the transverse velocity of the gas and the RF voltage.
Abstract translation: 提供离子源和离子导向室。 离子导向室具有气流，气流具有纵向速度和横向速度。 离子导向室具有出口孔和至少一个离子导向件。 所述至少一个离子导向器具有入口端和具有出口横截面的出口端，其中所述出口横截面的尺寸设定成比所述入口横截面更小的面积。 所述至少一个离子导向器具有多个细长电极，其中细长电极之间的间隙和间隙附近的细长电极的形状沿着至少一个离子导向器的长度基本相同，用于限制离子 通过气体的横向速度和RF电压的组合在间隙附近。
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公开(公告)号：US09514921B2
公开(公告)日：2016-12-06
申请号：US14907447
申请日：2014-08-07
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Nic G. Bloomfield , Alexandre V. Loboda
CPC classification number: H01J49/0009 , H01J49/0036 , H01J49/025 , H01J49/40
Abstract: Systems and methods are provided for correcting uniform detector saturation. In one method, a mass analyzer analyzes N extractions of an ion beam. A nonzero amplitude from an ADC detector subsystem is counted as one ion, producing a count of one for each ion of each sub-spectrum. The ADC amplitudes and counts of the N sub-spectra are summed, producing a spectrum that includes a summed ADC amplitude and a total count for each ion of the spectrum. A probability that the total count arises from single ions hitting the detector is calculated. For each ion of the spectrum where the probability exceeds a threshold value, an amplitude response is calculated, producing amplitude responses for ions found to be single ions hitting the detector. Amplitude responses are combined, producing a combined amplitude response. The total count is dynamically corrected using the combined amplitude response and the summed ADC amplitude.
Abstract translation: 提供了系统和方法来校正均匀的检测器饱和度。 在一种方法中，质量分析器分析离子束的N次提取。 来自ADC检测器子系统的非零幅度被计为一个离子，为每个子光谱的每个离子产生一个计数。 将N个子光谱的ADC幅度和计数相加，产生包括每个光谱离子的ADC幅度和总计数的谱的频谱。 计算总计数来自单个离子撞击检测器的概率。 对于概率超过阈值的频谱的每个离子，计算振幅响应，产生发现是单个离子撞击检测器的离子的振幅响应。 振幅响应被组合，产生组合振幅响应。 使用组合幅度响应和总和的ADC幅度动态校正总计数。
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公开(公告)号：US09165753B2
公开(公告)日：2015-10-20
申请号：US14368686
申请日：2012-12-04
Inventor： Alexandre V. Loboda , Paul Corkum , David Rayner
CPC classification number: H01J49/14 , H01J49/0031 , H01J49/0422 , H01J49/164 , H01J49/26
Abstract: The present disclosure generally provides ionization methods and devices for use in mass spectrometry. In some embodiments, the ionization methods and devices employ short laser pulses (e.g., pulses having pulsewidths in a range of about 2 fs to about 1 ps) at a high intensity (e.g., an intensity in a range of about 1 TW/cm2 to about 1000 TW/cm2) to ionize an analyte an ambient pressure greater than about 10−5 Torr (e.g., an ambient pressure in a range of about 1 atmosphere to about 100 atmospheres).
Abstract translation: 本公开通常提供用于质谱法的电离方法和装置。 在一些实施方案中，电离方法和装置在高强度下使用短激光脉冲（例如，具有约2fs至约1ps范围内的脉冲宽度的脉冲）（例如，在约1TT / cm 2至约1W / cm 2的范围内的强度 约1000TT / cm 2）以使分析物离子化大于约10 -5乇的环境压力（例如，约1大气压至约100大气压的环境压力）。
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