公开(公告)号：US20230377865A1

公开(公告)日：2023-11-23

申请号：US18247799

申请日：2021-10-07

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Yves Le Blanc ,  David M. Cox

IPC: H01J49/00 ,  G01N30/14 ,  G01N30/72

CPC classification number: H01J49/0045 ,  G01N30/14 ,  G01N30/7233 ,  G01N2030/027

Abstract: A tandem mass spectrometer may be operative to receive sample ions and to monitor a MS scan for a sentinel ion. Upon detection of the sentinel ion in MS1, the mass spectrometer switches to a group of at least one MS/MS scan associated with the sentinel ion to fragment incoming sample ions and to mass analyze resulting product ions of the fragmentation.

公开(公告)号：US10309930B2

公开(公告)日：2019-06-04

申请号：US15516387

申请日：2015-09-21

Applicant: DH Technologies Development Pte. Ltd.

Inventor： John Lawrence Campbell ,  Eva Duchoslav ,  Yves Le Blanc ,  David M. Cox

IPC: H01J49/26 ,  G01N27/62 ,  H01J49/00

Abstract: Systems and methods are provided for providing a DMS precursor ion survey scan. An ion source configured to receive a sample is instructed to ionize the sample using a processor. A DMS device configured to receive ions from the ion source is instructed to separate precursor ions received from the ion source and transmit precursor ions using two or more CoVs using the processor. A mass analyzer configured to receive transmitted precursor ions from the DMS device is instructed to measure the m/z intensities of the transmitted precursor ions across an m/z range at each CoV of the two or more CoVs using the processor. The measured m/z intensities of the transmitted precursor ions received from the mass analyzer are stored as a function of m/z value and CoV using the processor. This produces a stored two-dimensional mapping of m/z intensities of the precursor ions of the sample.

公开(公告)号：US09818590B2

公开(公告)日：2017-11-14

申请号：US14889139

申请日：2014-06-03

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： David M. Cox ,  Stephen A. Tate ,  Lyle Burton

IPC: G01N24/00 ,  H01J49/04 ,  H01J49/00

CPC classification number: H01J49/04 ,  H01J49/0027 ,  H01J49/0036 ,  H01J49/004

Abstract: Systems and methods are provided for identifying missing product ions after demultiplexing product ion spectra produced by overlapping precursor ion transmission windows in sequential windowed acquisition tandem mass spectrometry. Overlapping sequential windowed acquisition is performed on a sample. A first precursor mass window and the corresponding first product ion spectrum are selected from a plurality of overlapping stepped precursor mass windows and their corresponding product ion spectra. A product ion spectrum is demultiplexed for each overlapped portion of the first precursor mass window producing two or more demultiplexed first product ion spectra for the first precursor mass window. The two or more demultiplexed first product ion spectra are added together producing a reconstructed summed demultiplexed first product ion spectrum. Missing product ions are identified in the summed demultiplexed first product ion spectrum by comparing the summed demultiplexed first product ion spectrum and the first product ion spectrum.

公开(公告)号：US20160349210A1

公开(公告)日：2016-12-01

申请号：US15107455

申请日：2015-02-10

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Christie L. Hunter ,  David M. Cox

IPC: G01N27/62

CPC classification number: G01N27/622 ,  G01N30/7233 ,  H01J49/0027 ,  H01J49/004

Abstract: MRM triggered MRM, where the triggered MRM transitions make use of mobility device parameter values for the same compound, is performed. A plurality of primary MRM transitions are received and stored together with a mobility device parameter value for each transition as an MRM cycle list. Control information instructs a mobility device and a mass spectrometer to interrogate each MRM transition on the MRM cycle list within an MRM cycle of the mass spectrometer. If a product ion intensity value of an MRM transition exceeds a threshold value for a primary MRM transition, a plurality of secondary MRM transitions of the primary MRM transition with different mobility device parameter values are added to the MRM cycle list. The intensities of the measured secondary MRM transitions provide information on the optimum mobility device parameter for each compound.

Abstract translation: MRM触发MRM，其中触发的MRM转换使用相同化合物的移动设备参数值。 多个主MRM转换被接收并与每个转换的移动设备参数值一起存储为MRM周期列表。 控制信息指示移动设备和质谱仪在质谱仪的MRM周期内询问MRM周期列表上的每个MRM转换。 如果MRM转换的乘积离子强度值超过用于主MRM转换的阈值，则将具有不同移动性设备参数值的主MRM转换的多个辅助MRM转换添加到MRM周期列表。 所测量的次级MRM转换的强度提供了关于每种化合物的最佳移动性装置参数的信息。

公开(公告)号：US12191132B2

公开(公告)日：2025-01-07

申请号：US17753035

申请日：2020-08-22

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Yves Le Blanc ,  David M. Cox

IPC: H01J49/04 ,  H01J49/00 ,  H01J49/16

Abstract: Before a sample is introduced into a liquid sample delivery device, an ion source device receives aqueous mobile phase solution from the liquid sample delivery device and ionizes compounds of the aqueous mobile phase solution, producing an ion beam. A tandem mass spectrometer performs a first neutral loss scan of the ion beam with a first neutral loss value set to a molecular weight of a first known solvent, producing a first intensity, and performs a second neutral loss scan of the ion beam with a second neutral loss value set to a molecular weight of a second known solvent, producing a second intensity. A ratio of the first intensity to the second intensity is calculated. It is determined if the aqueous mobile phase solution is properly being delivered by the liquid sample delivery device based on the ratio.

公开(公告)号：US20230238232A1

公开(公告)日：2023-07-27

申请号：US17999635

申请日：2021-05-21

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： David M. Cox ,  Chang Liu ,  Stephen A. Tate

IPC: H01J49/04 ,  H01J49/00

CPC classification number: H01J49/0454 ,  H01J49/0404 ,  H01J49/0009 ,  H01J49/0027

Abstract: An ADE device identifies an identifiable sequence of one or more ejections from at least one sample using a different value or pattern of values for one or more ADE parameters. The identifiable one or more ejections are performed to produce one or more mass peaks that have a different feature value or pattern of feature values for one or more peak features than other mass peaks produced. Ejection times are stored. One or more detected peaks with the different feature values or pattern of feature values are identified as produced by the identifiable one or more ejections. A delay time is calculated from the time of the identifiable ejections and the time of the identified detected peaks and the peaks are aligned with samples using delay time, stored times, and order of the samples.

公开(公告)号：US20180269048A1

公开(公告)日：2018-09-20

申请号：US15754770

申请日：2016-08-09

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Michael Jarvis ,  Yves Le Blanc ,  David M. Cox

IPC: H01J49/00 ,  G01N27/62

CPC classification number: H01J49/0036 ,  G01N27/624 ,  H01J49/0027 ,  H01J49/004

Abstract: Systems and methods are provided for enabling or disabling a DMS device during an IDA method. Each cycle of the method includes a survey scan step, producing a precursor ion mass spectrum, and an MS/MS scan step. During the MS/MS scan step, one or more user-defined MS/MS scans are performed that correspond to compounds of interest found in the precursor ion mass spectrum. With each user-defined MS/MS scan, a DMS enable parameter that determines if the DMS device is enabled or disabled and one or more DMS parameters necessary to enable the DMS device for the corresponding compound of interest are received. During the MS/MS scan step, for each user-defined MS/MS scan, the DMS device is enabled or disabled according to the DMS enable parameter and one or more parameters of the DMS device are set according to the one or more DMS parameters.

公开(公告)号：US09733214B2

公开(公告)日：2017-08-15

申请号：US15107455

申请日：2015-02-10

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Christie L. Hunter ,  David M. Cox

IPC: H01J49/00 ,  G01N27/62 ,  G01N30/72

CPC classification number: G01N27/622 ,  G01N30/7233 ,  H01J49/0027 ,  H01J49/004

Abstract: MRM triggered MRM, where the triggered MRM transitions make use of mobility device parameter values for the same compound, is performed. A plurality of primary MRM transitions are received and stored together with a mobility device parameter value for each transition as an MRM cycle list. Control information instructs a mobility device and a mass spectrometer to interrogate each MRM transition on the MRM cycle list within an MRM cycle of the mass spectrometer. If a product ion intensity value of an MRM transition exceeds a threshold value for a primary MRM transition, a plurality of secondary MRM transitions of the primary MRM transition with different mobility device parameter values are added to the MRM cycle list. The intensities of the measured secondary MRM transitions provide information on the optimum mobility device parameter for each compound.

公开(公告)号：US12300478B2

公开(公告)日：2025-05-13

申请号：US17999569

申请日：2021-05-21

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： David M. Cox ,  Chang Liu

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/16

Abstract: Each sample of a series of samples is ejected at an ejection time and according to a sample order. Each ejected sample of the series is ionized, producing ion beam. A list of different sets of MRM transitions is received. Each set of the list corresponds to a different sample. A group of one or more different sets is selected from the list. Initially, each set selected for the group corresponds to a different sample of one or more first samples of the series. A mass spectrometer is instructed to execute each transition of each set of the group on the ion beam until a transition of a set of the group is detected, upon which, one or more next sets are selected from the list to be monitored using the set of the detected transition and the sample order.

公开(公告)号：US11953478B2

公开(公告)日：2024-04-09

申请号：US17593349

申请日：2020-03-10

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Nic G. Bloomfield ,  Lyle Lorrence Burton ,  John Lawrence Campbell ,  David M. Cox ,  Eva Duchoslav ,  Adam San-Ho Lau

IPC: H01J49/00 ,  G01N30/72 ,  G01N30/86 ,  H01J49/04 ,  H01J49/16 ,  H01J49/42 ,  H01J49/44

CPC classification number: G01N30/8631 ,  G01N30/7206 ,  G01N30/7233 ,  H01J49/0031 ,  H01J49/0418 ,  H01J49/167 ,  H01J49/4225 ,  H01J49/446

Abstract: Each of one or more unknown compounds are separated from a sample over a separation time period. Separated compounds are ionized, producing one or more compound precursor ions for each of the unknown compounds and a plurality of background precursor ions. A precursor ion mass spectrum is measured for the combined compound and background precursor ions at each time step of a plurality of time steps spread across the separation time period, producing a plurality of precursor ion mass spectra. One or more background precursor ions are selected from the plurality of precursor ion mass spectra that have a resolving power in a range below a threshold expected resolving power. A separation time is detected for an unknown compound when a decrease in an intensity measurement of the selected background precursor ions over a time period exceeds a threshold decrease in intensity with respect to time.