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Patent Agency Ranking
公开(公告)号：US20210265150A1
公开(公告)日：2021-08-26
申请号：US17255861
申请日：2019-06-28
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W Arnold , Thomas R Covey , Chang Liu
IPC: H01J49/04
Abstract: Methods and systems for delivering liquid sample to an ion source and subsequent analysis by mass spectrometry. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which desorption solvent is used in sampling interface to desorb analyte species from an SPME device that is coupled to an ion source to ionize analyte species desorbed into the desorption solvent for MS analysis (e.g., without a liquid chromatography (LC) column between the sampling interface and the ion source). In various aspects of the methods and systems described herein, configuring the sampling interface can be optimized so as to reduce the fluid volume dead space about the fluid inlet so as to concentrate the one or more analyte species desorbed at optimized conditions from the SPME substrate in a decreased volume of the desorption solvent when the SPME device is inserted into sampling interface.
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公开(公告)号：US11348780B2
公开(公告)日：2022-05-31
申请号：US16765910
申请日：2018-11-20
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W Arnold , Thomas R. Covey , Chang Liu
Abstract: An ultrasonic transmitter (95) and detector (e.g., integrated as an ultrasound transducer) utilized in a feedback control system automatically monitors and/or detects surface profile (e.g., shape) of the liquid-air interface and adjusts the flow rate of sampling liquid to ensure that experimental conditions remain consistent at the time of sample introduction during serial samplings. The feedback control can provide for automated adjustment of the surface profile of the liquid-air interface in accordance with changes in desired set point according to an experimental workflow (e.g., automated adjustment between an interface corresponding to a vortex sampling set point and an overflow cleaning set point). Improvements in desorption efficiency and quality of mass spectrometry data by degassing of the liquid solvent utilized within the sampling interfaces, and/or utilization in a feedback control system for generating data indicative of a surface profile of the liquid-air interface within the interface's sampling port may be realized.
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公开(公告)号：US11232939B2
公开(公告)日：2022-01-25
申请号：US16765958
申请日：2018-11-20
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W Arnold , Thomas R. Covey , Chang Liu , Bogdan Morosan
Abstract: Mass spectrometer based analytical systems and methods in which a feedback control system can be utilized to control the flow of liquid within a sampling probe to adjust and/or maintain the surface profile (e.g., shape) of the liquid-air interface within an open sampling port of the sampling probe. The feedback control systems can automatically monitor and/or detect the surface profile of the liquid-air interface and adjust the flow rate of the sampling liquid to ensure that experimental conditions remain consistent at the time of sample introduction during serial samplings. These can provide stable and reproducible analyte flows of consistent dilution to the ion source, increasing reproducibility and/or accuracy of data generated by MS analysis. Can be used with a change in the desired set point according to the particular experimental workflow (e.g., automated adjustment between an interface corresponding to a sampling set point and a cleaning set point).
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公开(公告)号：US12138606B2
公开(公告)日：2024-11-12
申请号：US16765854
申请日：2018-11-20
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W Arnold , Thomas R. Covey , Chang Liu
IPC: B01F33/451 , B01F23/50 , B01F35/221 , B03C1/01 , B03C1/033 , B03C1/28 , B03C1/30 , G01R33/12 , B01F101/23
Abstract: A fluid processing system that can include a sample container having a sample chamber for containing a fluid and a plurality of magnetic particles and at least one movable magnetic assembly configured to be movably inserted into or out of the sample chamber. The movable magnetic assembly can include a plurality of electromagnets that generate a magnetic field within at least a portion of the sample chamber when the assembly is inserted at least partially into the sample chamber. The fluid processing system can also include a signal generator that applies electrical signals, e.g., AC electrical signals, to the electromagnets of the magnetic assembly and a controller coupled to the signal generator that is configured to control phases of the electrical signals applied to the electromagnets to generate magnetic field gradients within the portion of the sample chamber effective to magnetically influence the plurality of the magnetic particles.
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公开(公告)号：US11232938B2
公开(公告)日：2022-01-25
申请号：US17255861
申请日：2019-06-28
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Don W Arnold , Thomas R Covey , Chang Liu
Abstract: Methods and systems for delivering liquid sample to an ion source and subsequent analysis by mass spectrometry. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which desorption solvent is used in sampling interface to desorb analyte species from an SPME device that is coupled to an ion source to ionize analyte species desorbed into the desorption solvent for MS analysis (e.g., without a liquid chromatography (LC) column between the sampling interface and the ion source). In various aspects of the methods and systems described herein, configuring the sampling interface can be optimized so as to reduce the fluid volume dead space about the fluid inlet so as to concentrate the one or more analyte species desorbed at optimized conditions from the SPME substrate in a decreased volume of the desorption solvent when the SPME device is inserted into sampling interface.
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